2011
DOI: 10.2478/v10181-011-0028-5
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The influence of botulinum toxin type A (BTX) on the immunohistochemical characteristics of noradrenergic and cholinergic nerve fibers supplying the porcine urinary bladder wall

Abstract: Botulinum toxin (BTX) belongs to a family of neurotoxins which strongly influence the function of autonomic neurons supplying the urinary bladder. Accordingly, BTX has been used as an effective drug in experimental therapies of a range of neurogenic bladder disorders. However, there is no detailed information dealing with the influence of BTX on the morphological and chemical properties of nerve fibres supplying the urinary bladder wall. Therefore, the present study investigated, using double-labeling immunohi… Show more

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Cited by 10 publications
(20 citation statements)
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“…We can therefore conclude that the toxin does not affect the noradrenergic profile of these nerve cells. This observation corresponds well with results of a previous study (Lepiarczyk et al 2011 ) that has revealed that BTX-treatment does not decrease the number of DβH+ nerve fibres distributed in the wall of the porcine female urinary bladder. As mentioned before, the release of the sympathetic neurotransmitter noradrenaline (NA) allows continence to be achieved (Andersson and Arner 2004 ; Morrison et al 2005 ).…”
Section: Discussionsupporting
confidence: 93%
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“…We can therefore conclude that the toxin does not affect the noradrenergic profile of these nerve cells. This observation corresponds well with results of a previous study (Lepiarczyk et al 2011 ) that has revealed that BTX-treatment does not decrease the number of DβH+ nerve fibres distributed in the wall of the porcine female urinary bladder. As mentioned before, the release of the sympathetic neurotransmitter noradrenaline (NA) allows continence to be achieved (Andersson and Arner 2004 ; Morrison et al 2005 ).…”
Section: Discussionsupporting
confidence: 93%
“…The noradrenergic efferent pathways facilitate relaxation of the detrusor muscle via β-adrenoreceptors and excite the bladder base and urethra via α 1 -adrenoreceptors, thus achieving continence (Andersson and Arner 2004 ; Morrison et al 2005 ). Notably, some information suggests that BTX can affect noradrenergic transmission in the lower urinary tract (Smith et al 2003 ; Wojtkiewicz et al 2008 ; Lepiarczyk et al 2011 ).…”
Section: Introductionmentioning
confidence: 99%
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“…The urine storage process largely depends upon the undisturbed and coordinated control of sympathetic-parasympathetic innervation of the urinary bladder (for review see: [ 2 ]). In our previous study [ 5 ], we found that BTX strongly influences immunohistochemical characteristics of noradrenergic and cholinergic axons distributed in the porcine urinary bladder wall. The present contribution was aimed at comparing the influence of two other neurotoxins, RTX and tetrodotoxin (TTX), on the distribution, relative frequency, and chemical coding of cholinergic and noradrenergic nerve fibers (NF) supplying this organ.…”
Section: Introductionmentioning
confidence: 99%
“…It has been shown that this neurotoxin inhibits ACh release from efferent nerve terminals in the lower urinary tract [ 5 ]. Furthermore, Lepiarczyk et al [ 24 ] have revealed that BTX causes profound changes in the pattern of distribution, relative frequency, and chemical coding of cholinergic nerve fibers supplying the porcine urinary bladder wall. However, recently published data clearly suggest that BTX may also significantly influence the sensory innervation of the lower urinary tract tissues.…”
Section: Introductionmentioning
confidence: 99%