The influence of breast milk and infant formulae hydrolysates on bacterial adhesion and Caco-2 cells functioning

Fiedorowicz, Ewa; Markiewicz, Lidia Hanna; Sidor, Katarzyna; Świątecka, D; Cieślińska, Anna; Matysiewicz, Michał; Piskorz-Ogórek, Krystyna; Sienkiewicz-Szłapka, Edyta; Teodorowicz, Małgorzata; Świątecki, Aleksander; Kostyra, Elżbieta

doi:10.1016/j.foodres.2016.09.022

Cited by 19 publications

(16 citation statements)

References 43 publications

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“…To the best of our knowledge, no research studies regarding the identification and quantitation of bBCMs in undigested commercial milk fortifiers are available. The presence of bBCM7 in HM (and hence in UF permeate) has been reported by (Jarmołowska et al, 2007) and (Fiedorowicz et al, 2016) at 0-2.8 mg L -1 and 0.6-0.7 µg L -1 , respectively. Moreover, (Jarmołowska et al, 2007) found bBCM5 up to 10.6 mg L -1 in the same HM samples.…”

Section: Occurrence Of Bbcms In (Un)digested Fortifiers For Pdhmmentioning

confidence: 69%

“…These proteoses derive from the plasminolysis of bovine β CN naturally occurring in the mammary gland and during milk storage. Similarly, (Fiedorowicz et al, 2016) found 33 µg L -1 of bBCM7 in an undigested liquid infant formula, for term infants, exclusively made from hydrolyzed bovine whey proteins.…”

Section: Occurrence Of Bbcms In (Un)digested Fortifiers For Pdhmmentioning

confidence: 82%

“…Moreover, (Jarmołowska et al, 2007) found bBCM5 up to 10.6 mg L -1 in the same HM samples. According to (Fiedorowicz et al, 2016), the presence of bBCMs in HM was the result of their transfer from mother's sera (blood) into HM. In this regard, (Kost et al, 2009) found immunoreactive substances against bBCM7 in blood plasma of breast-fed infants.…”

Section: Occurrence Of Bbcms In (Un)digested Fortifiers For Pdhmmentioning

confidence: 99%

“…Other bBCMs are bBCM3 (f60-62), bBCM4 (f60-63) and bBCM6 (f60-65). Many studies reported the potential biological effect of bBCMs in adults and infants as mainly caused by interaction of bBCM7 with the μ opioid receptor (MOR) (Banks, 2015;Enjapoori, Kukuljan, Dwyer, & Sharp, 2019;Fiedorowicz et al, 2016;Kost et al, 2009). In fact, bBCMs are suspected to be involved in the onset or worsening of several non-communicable diseases (EFSA, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Effect of protein fortification on heat damage and occurrence of β-casomorphins in (un)digested donor human milk intended for nutrition of preterm infants

et al. 2020

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and myself to be considered for publication in the "Food Chemistry". Highlights  Pasteurized donor human milk (PDHM) is fortified for preterm infant nutrition  Hydrolyzates of bovine milk proteins are used for fortification of PDHM  Hydrolyzates contain casomorphins (BCMs) and present protein chemical artifacts  Hydrolyzates account for the protein artifacts of PDHM  Digestion of fortified PDHM releases bovine and human BCMs *Highlights (for review)

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Section: Occurrence Of Bbcms In (Un)digested Fortifiers For Pdhmmentioning

confidence: 69%

Section: Occurrence Of Bbcms In (Un)digested Fortifiers For Pdhmmentioning

confidence: 82%

Section: Occurrence Of Bbcms In (Un)digested Fortifiers For Pdhmmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of protein fortification on heat damage and occurrence of β-casomorphins in (un)digested donor human milk intended for nutrition of preterm infants

et al. 2020

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“…The gut microbiome is mainly shaped during the first months of life by different factors, including vaginal delivery, the host's genome, breastfeeding or formula feeding, use of antibiotics, GI infections and stress [2,19]. Diet is a factor that influences the bacterial composition also later in life [8,24,36,37]. …”

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confidence: 99%

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2015

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There is a rising interest in the use of dietary interventions to ameliorate prevalent brain diseases, including Autism Spectrum Disorder (ASD). Nowadays, the existence of communication between gut and brain is well accepted and thus diet can influence brain functioning. A well-known nutrition based intervention for ASD is the gluten-free and casein-free diet. However, only some of the patients experience a relief in symptoms and thus efficacy seems to be limited to certain phenotypes. However, not much is known about the mechanism of action through which this diet might work, or about interpersonal differences that could lead to variation in response to the diet. Current evidence for efficacy of the GFCF diet is poor. Large scale, good quality randomized controlled trials are needed. Genetic and environmentally induced interpersonal differences were found in intestinal membrane permeability and blood brain barrier integrity as well as in activity of peptidase enzymes. These differences probably affect responsiveness to the diet. In addition, age and duration of the dietary intervention play a role in the efficacy of the gluten-free and casein-free diet. This is the reason why all these factors need to be taken into account to give appropriate advice about whether or not to follow this diet.Keywords: Autism spectrum disorder; Casein-free; Casomorphin; Diet; Gluten-free; Intervention; Opioid; Peptides; Permeability Treating Autism Spectrum Disorder with Gluten-free and Casein-free Diet: The underlying Microbiota-Gut-Brain Axis MechanismsCitation: Cieślińska A, Kostyra E, Savelkoul HFJ (2017) Treating Autism Spectrum Disorder with • (GFCF) diet is strongly promoted while there are additional diets without salicylates and phenols, and anti-candida diets since many ASD patients are affected by this yeast [17]. However, so far it has been difficult to prove the effectiveness of this diet in all patients [10,18]. Limited information is available on the underlying mechanism as well as explanatory factors of differences in response to the GFCF diet. Here, we focus on the mechanism of action underlying this dietary intervention as well as the origin of differences in response to the GFCF diet. Gluten-Free and Casein-Free Diet Might Alleviate Autism Spectrum Disorder SymptomsPeople with ASD are often in need of intensive care and guidance, leading to loss of parental productivity and high emotional and economic costs [8,19]. Therefore it is important to investigate potential treatments that alleviate the symptoms or preferably cure the disease. So far, sometimes life long, educational and behavioral interventions are used, although these therapies have limited efficacy for ASD [6,20]. Currently, there is growing interest in nutritional interventions for this disorder and there are promising mechanisms underlying the putative success of such interventions [19].In 1983 it was suggested that gluten and casein containing products could cause autism-like symptoms by altering the functioning of the brain. It was propo...

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