The Influence of Breathing Pattern During Nebulization on the Emitted Dose of Arformoterol

Bauer, Andrea; McGlynn, Paul; Bovet, Li Li; Mims, Pamela L; Curry, Lisa; Hanrahan, John P.

doi:10.1378/chest.132.4_meetingabstracts.616b

Cited by 18 publications

(22 citation statements)

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“…These results are limited to the combination of device and mask most commonly used (continuous output jet nebulizer and bottom-loaded mask). This is in agreement with findings reported by Bauer et al, 13 who compared nebulized arformoterol output using different breathing patterns. They also found that larger exposure times resulted in larger drug outputs.…”

Section: Discussionsupporting

confidence: 93%

Effect of Mask Dead Space and Occlusion of Mask Holes on Delivery of Nebulized Albuterol

Berlinski

2013

Respir Care

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, and adult (V T ‫؍‬ 500 mL, breathing frequency ‫؍‬ 15 breaths/min, I:E ‫؍‬ 1:2) breathing patterns was connected to a collection filter hidden behind a face plate. A pediatric size mask and an adult size mask connected to a continuous output jet nebulizer were sealed to the face plate. Three nebulizers were loaded with albuterol sulfate (2.5 mg/3 mL) and operated with 6 L/min compressed air for 5 min. Experiments were repeated with different degrees of occlusion (0%, 50%, and 90%). Albuterol was extracted from the filter and measured with a spectrophotometer at 276 nm. RESULTS: Occlusion of the holes in the large mask did not increase the amount of albuterol in any of the breathing patterns. The amount of albuterol captured at the mouth opening did not change when the small mask was switched to the large mask, except with the breathing pattern of a child, and when the holes in the mask were 50% occluded (P ‫؍‬ .02). CONCLUSIONS: Neither decreasing the dead space of the mask nor occluding the mask holes increased the amount of nebulized albuterol captured at the mouth opening.

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Section: Discussionsupporting

confidence: 93%

Effect of Mask Dead Space and Occlusion of Mask Holes on Delivery of Nebulized Albuterol

Berlinski

2013

Respir Care

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“…23 A breathing simulator is a computerized piston pump that allows programming of respiratory parameters to mimic different breathing conditions. Calibration of breathing simulator (Pari Compass) was verified at the beginning of each testing by a mass flow meter (model 4043, TSI, Shoreview, Minnesota) and its associated software.…”

Section: Breathing Simulationmentioning

confidence: 99%

Longitudinal Evaluation of Compressor/Nebulizer Performance

2013

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“…In the inhaler presentation (pressurized metered dose inhalers and dry powder inhalers), FP can prove ineffective in some children, elderly asthma patients, and some patients with severe asthma, particularly those who experience difficulty with co-ordination or during exacerbations (8).…”

Section: Introductionmentioning

confidence: 99%

Comparison of fluticasone propionate with budesonide administered via nebulizer: a randomized controlled trial in patients with severe persistent asthma

et al. 2017

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Background: This study compared the efficacy and safety of fluticasone propionate (FP) inhalation n solution with budesonide (BUD) suspension for inhalation administered via nebulizer, in Chinese adult patients with severe, persistent asthma. Methods: This was a multicenter, randomized, active-controlled, single-blind, parallel-group study, conducted at 26 clinical sites in China. Participants were randomized 1:1 to FP nebules 1 mg twice daily or BUD 2 mg twice daily via nebulizer for 12 weeks. Results: A total of 317 adult patients were randomized. The primary endpoint was mean change in

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The Influence of Breathing Pattern During Nebulization on the Emitted Dose of Arformoterol

Cited by 18 publications

References 0 publications

Effect of Mask Dead Space and Occlusion of Mask Holes on Delivery of Nebulized Albuterol

Effect of Mask Dead Space and Occlusion of Mask Holes on Delivery of Nebulized Albuterol

Longitudinal Evaluation of Compressor/Nebulizer Performance

Comparison of fluticasone propionate with budesonide administered via nebulizer: a randomized controlled trial in patients with severe persistent asthma

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