Media’s ability to enhance the salience of certain topics for the public and affect governmental policy-setting processes is widely recognized. This is particularly evident in health communication, where newspapers are one of the most important sources of health information. This study compares media depictions of tick-borne disease in the United States and China. Both countries are experiencing an increase in tick-borne diseases and have vastly different media landscapes. To investigate US and Chinese newspaper coverage of tick-borne diseases, a content analysis was conducted of four US and four Chinese newspapers. The analysis considered length, tone, chief actors, and themes present in articles covering tick-borne diseases from 2010-2015. The findings reveal significant differences between the two nations on length of the articles, chief actors portrayed in the articles, and themes present in the articles. The data also show: tick-borne disease stories were overwhelmingly framed in a neutral way in both nations; newspapers in the US featured more celebrity-related stories compared to newspapers in China; and US stories as opposed to those in China focused more on health policies.