The influence of carrier roughness on adhesion, content uniformity and the in vitro deposition of terbutaline sulphate from dry powder inhalers

Flament, Marie‐Pierre; Leterme, P.; Gayot, A.

doi:10.1016/j.ijpharm.2004.02.002

Cited by 106 publications

(67 citation statements)

References 11 publications

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“…lactose or hydrophobic components like magnesium stearate or amino acids [37,39,40]. Surface roughness of the carrier particles (in contrast to the surface roughness of small inhalable particles) may introduce asperities which could entrap drug particles and may resist its detachment from the carrier during inhalation [41,42]. Two mechanisms by which fines improve de-aggregation are suggested because the aerosolization performance of the drug was shown to be both affected and unaffected by the blending order [43].…”

Section: New Powder Formulation Methodsmentioning

confidence: 99%

Novel dry powder inhalation system based on dispersion of lyophilisates

Claus

Schoenbrodt

Weiler

et al. 2011

European Journal of Pharmaceutical Sciences

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Section: New Powder Formulation Methodsmentioning

confidence: 99%

Novel dry powder inhalation system based on dispersion of lyophilisates

Claus

Schoenbrodt

Weiler

et al. 2011

European Journal of Pharmaceutical Sciences

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“…Numerous groups (Bosquillon et al, 2001;Donovan and Smyth, 2010;Flament et al, 2004;Heng et al, 2000;Jones and Price, 2006;Kinnunen et al, 2014;Ooi et al, 2011;Young et al, 2009;Zellnitz et al, 2013Zellnitz et al, , 2014 investigated the correlation between excipient particle size, surface roughness and formulation performance with the aim of optimising these properties. Formulation performance was related to particle size and roughness of a budesonide-lactose formulation by Donovan and Smyth (2010); particle roughness and adhesion of a terbutaline sulphate-lactose formulation by Flament et al (2004); and to the percentage of carrier surface coverage in a model salbutamol sulphate formulation by Zellnitz et al (2014). Ferrari et al (2004) looked at the effect of wet-smoothing on the rugosity of lactose carrier particles.…”

Section: Topographical Imagingmentioning

confidence: 99%

Characterisation of dry powder inhaler formulations using atomic force microscopy

Weiss

McLoughlin

Cathcart

2015

International Journal of Pharmaceutics

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A B S T R A C TInhalation formulations are a popular way of treating the symptoms of respiratory diseases. The active pharmaceutical ingredient (API) is delivered directly to the site of action within the deep lung using an inhalation device such as the dry powder inhaler (DPI).The performance of the formulation and the efficiency of the treatment depend on a number of factors including the forces acting between the components. In DPI formulations these forces are dominated by interparticulate interactions. Research has shown that adhesive and cohesive forces depend on a number of particulate properties such as size, surface roughness, crystallinity, surface energetics and combinations of these. With traditional methods the impact of particulate properties on interparticulate forces could be evaluated by examining the bulk properties. Atomic force microscopy (AFM), however, enables the determination of local surface characteristics and the direct measurement of interparticulate forces using the colloidal probe technique. AFM is considered extremely useful for evaluating the surface topography of a substrate (an API or carrier particle) and even allows the identification of crystal faces, defects and polymorphs from high-resolution images. Additionally, information is given about local mechanical properties of the particles and changes in surface composition and energetics. The assessment of attractive forces between two bodies is possible by using colloidal probe AFM.This review article summarises the application of AFM in DPI formulations while specifically focussing on the colloidal probe technique and the evaluation of interparticulate forces.2015 Elsevier B.V. All rights reserved.

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“…Surface morphology has been demonstrated to directly influence the contact area between drug particle and carrier, leading to variations in interparticulate adhesion. Several studies have reported that variations in contact area, as a result of differing surface structure, could potentially compromise the aerosolization performance of the drug particles Flament et al, 2004;. Some surface modifications of carrier particles have been reported to improve inhalation performance of DPI (Kawashima et al, 1998;Chan et al, 2003).…”

Section: Carrier Surfacementioning

confidence: 99%