The influence of Chlamydia trachomatis infection on spontaneous abortions

Wilkowska-Trojniel, M; Zdrodowska-Stefanow, B; Ostaszewska-Puchalska, Iwona; Redźko, S; Przepieść, Jerzy; Zdrodowski, M

doi:10.2478/v10039-009-0008-5

Cited by 36 publications

(28 citation statements)

References 8 publications

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“…Previous studies Chlamydia trachomatis suggested as an etiologic factor for spontaneous abortion (Wilkowska-Trojniel et al, 2009;Avasthi et al, 2003;Bakhtiari and Firoozjahi, 2007). In a research performed by Avasthi et al (2003) Chlamydia trachomatis suggested as an etiologic factor for spontaneous abortion in Ludhiana.…”

Section: Discussionmentioning

confidence: 99%

<i>Chlamydia trachomatis</i> in Women with Ful-Term Deliveries and Women with Abortion

Jahromi¹

2010

American Journal of Infectious Diseases

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Problem statement: There are some documents which support the role of some certain infections such as Chlamydia trachomatis in spontaneous abortion. As there were not data about role this bacterium in abortion in this area of IRAN, this study was conducted to evaluate the prevalence of Chlamydia trachomatis in women with abortion and compare it with healthy women with no previous history of abortion. Approach: This case-control study was carried out in Shariatee hospital of Hormozgan University of medical sciences, during [2004][2005]. A number of 220 women with definite diagnosis of previous abortion and 200 matched women with normal full term delivery and negative history of miscarriage as controls were studied as case and control groups. All obtained PAP smears from the case and the control groups were then tested using Immunoflourescent method for detection of Chlamydia trachomatis. Data was analyzed, using SPSS software (chi square and t-test). Results: The prevalence of positive direct immunofluorescent test on PAP smears indicating the presence of Chlamydia trachomatis was 56 (25.45%) in women with abortion comparing to 13 (5.20%) in women in control group, the difference was significant (p = 0.0001). Conclusion: This study showed Chlamydia trachomatis is an important causative agent for abortion in this area of IRAN.

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Section: Discussionmentioning

confidence: 99%

<i>Chlamydia trachomatis</i> in Women with Ful-Term Deliveries and Women with Abortion

Jahromi¹

2010

American Journal of Infectious Diseases

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“…Several patients exhibited C. trachomatis-positive serologic results without C. trachomatis DNA suggests that miscarriage might also occasionally be induced by damage from a past chlamydial infection or persistent C. trachomatis antibodies that might interfere with embryonic antigens (15). The study (16) inspected 120 ladies with a specific end goal to evaluate the recurrence of C. trachomatis diseases in patients with a past filled with premature delivery. In a gathering of ladies with one unconstrained premature delivery, higher IgG particular antibodies were identified in serum by ELISA in 21.1% of the women, in women with at least two unconstrained unsuccessful labor 36.4%.…”

Section: Resultsmentioning

confidence: 99%

Immunological and molecular study of Chlamydia trachomatis as causative agent of abortion in Al-Muthanna province

Al-Jandeel¹

2018

Iraqijvm

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SummaryChlamydiasis during pregnancy should be considered a significant risk factor for adverse pregnancy outcomes in humans. 120 women who had a single or repeated abortion were selected for this study, and they were referred with a physician report for TORCH tests to determine the final diagnosis of pregnancy loss. The control were (40) healthy pregnant women with a history of a normal pregnancy. The innate immunity in abortive women was higher than normal pregnancies, that was estimated by Nitroblue Tetrazolium test done to estimate the phagocytic activity, there was a significant increase (P=0.009) in phagocytic activity in the leukocytes of abortive women which was (22%) higher than that in control. Also, the cellular immune response was higher in abortive women than that in control. Methyl Thiazolyl Tetrazolium assay was performed to estimate lymphocyte transformation index of peripheral blood leukocytes in abortive women. The results of Methyl Thiazolyl Tetrazolium assay showed a significant increase (P=0.001) in the lymphocyte transformation index in the lymphocytes of abortive women which was (27%) higher than control. The serological detection by ELISA showed that anti-C. trachomatis IgG was (14.2%), and the molecular detection by Quantitive Real Time-Polymerase Chain Reaction showed positive results (17.5%) of total abortive women. The present study demonstrated a high level of relationship between C. trachomatis and abortion among women in the study samples. The age group (20-25years) was the most susceptible to chlamydial infection and the infection was higher in recurrent miscarriages than in single miscarriage.

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“…A recent Polish study found that the prevalence of C. trachomatis detected by NAATs and serology was higher in women who miscarried than in other pregnant women, suggesting that chlamydial infection can cause spontaneous pregnancy loss (97). However, studies designed to analyse the possible role of C. trachomatis in miscarriage are lacking and this issue continues to be controversial.…”

Section: Pregnancy Outcomesmentioning

confidence: 98%