The influence of cholesterol and fat in maternal diet of rats on the development of hepatic cholesterol metabolism in the offspring

Naseem, Syed M.; Khan, Mushtaq Ahmad; Heald, Felix P.; Nair, Padmanabhan P.

doi:10.1016/0021-9150(80)90193-8

Cited by 32 publications

(8 citation statements)

References 19 publications

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“…Similarly, Feingold et al [35] found no effect of 2% maternal dietary cho lesterol on rat fetal hepatic cholesterogenesis. In contrast, Naseem et al [6,7] have given evidence of a lasting reduced HMGCoA reductase activity in the progeny of rats fed high fat and cholesterol diets in preg nancy [6,7], The difference of these to present and earlier studies [34,35] may be the use of 40% diet fat. Similar very high fat diets have been found to cause increased pla cental and reduced fetal weights [unpub lished observations], and fetal ketonemia and altered placental amino acid and glucose transfer [36], Glucocorticoids have a well-known abil ity to induce TAT and FAS in adult rat liver [37,38] and cystathionase in fetal liver [15], In the adult rat, hepatic cystathionase is in sensitive to glucocorticoid, but is suppressed by T4.…”

Section: Resultscontrasting

confidence: 51%

“…Studies on the re lationship of early diet to adult cholesterol metabolism have employed diets rich in satu rated fat and cholesterol [2,6,7] and have been interpreted to suggest that rat HMGCoA reductase is most susceptible to long term alteration during prenatal life [6]. High fat and cholesterol diets, also appear to lead to accumulation of adrenal cholesterol [16] and increased plasma corticosterone [17] in male rats.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Chronic Modification of Diet Fat and Cholesterol during Gestation on Plasma Hormones and Hepatic Enzyme Activities in Rat Fetus

Innis

Haave²

1988

Neonatology

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Diet-induced elevation of cholesterol and corticosterone in pregnant rats had no effect on fetal plasma cholesterol or corticosterone, 3-hydroxy-3-methylglutaryl coenzyme A or hepatic reductase activities. The data suggest that increasing the maternal cholesterol pool has no effect on cholesterol transfer to, or metabolism in, the developing offspring, and that the late gestation fetus can maintain corticosterone levels appropriate to gestational age despite diet-induced elevations in the maternal plasma.

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Section: Resultscontrasting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Effect of Chronic Modification of Diet Fat and Cholesterol during Gestation on Plasma Hormones and Hepatic Enzyme Activities in Rat Fetus

Innis

Haave²

1988

Neonatology

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“…Changes in cholesterol metabolism in vivo are the main factors causing dyslipidemia. Animal models have demonstrated that maternal malnutrition during pregnancy can modify cholesterol synthesis and lead to elevated plasma cholesterol levels, and maternal malnutrition before and during pregnancy permanently alters cholesterol metabolism(Lucas et al, ; Naseem et al, ). Another study by Roseboom et al reported for the first time that maternal nutrition during early pregnancy can permanently affect lipid profiles later in life in humans (Roseboom et al, ), which may partly explain why people exposed to famine in utero were more susceptible to dyslipidemia.…”

Section: Discussionmentioning

confidence: 99%

Famine Exposure during the Fetal Period Increased the Risk of Dyslipidemia in Female Adults

Yao

2019

Lipids

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Chronic diseases are gradually becoming public health challenges around the world. This study was designed to explore the relationship between early life exposure to famine in China and the risk of dyslipidemia during adulthood. A total of 604 subjects born from 1955 to 1965 received a health checkup and completed a questionnaire survey at the health management center of the tertiary hospital in Hefei, China, in 2013. A logistic regression model was used to assess dyslipidemia in famine-exposed and nonexposed individuals. Overall, exposure to famine during the fetal (OR 1.37; 95% CI: 0.90-2.10; and p = 0.14) and childhood (OR 0.97; 95% CI: 0.67-1.41; and p = 0.89) periods did not significantly increase the risk of dyslipidemia in adulthood compared with no exposure group. For females, exposure to famine during the fetal period (OR 2.00; 95% CI: 1.03-3.86; and p = 0.04) significantly increased the risk of dyslipidemia in adulthood compared to no exposure; however, this difference was not found in males. Exposure to famine in early life leads to altered lipid distribution in adulthood, and the risk of dyslipidemia significantly increased in adult women who were exposed to famine during the fetal period. Our study further validated the relationship between famine exposure during pregnancy and increased risk of dyslipidemia in female adult offspring. This study provides a scientific basis for the prevention and control of abnormal blood lipid levels in adults.

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“…However, a longer follow-up showed that at the age of 7-12 years the concentrations of CS in the plasma were lower in children fed low-CS diets during the neonatal period than in those fed diets with higher CS content [4]. High CS consumption at the early stages of development led to an increase in blood CS content in rats which was retained in adult age and affected enzymes regulating CS homeostasis [6]. Similar data were obtained in experiments with baboons.…”

Section: Resultsmentioning

confidence: 91%

Effect of alimentary hypercholesterolemia in female rabbits on blood lipid levels in their progeny

1998

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Female rabbits fed cholesterol-rich diet during pregnancy and/or lactation developed hypercholesterolemia and their progeny had higher lipid levels than the progeny of normolipidemic females. The weight of rabbits born from or fed by females with alimentary hypereholesterolemia was lower than normal during the entire observation period (40 weeks). After weaning (at the age of 6 weeks), serum concentrations of cholesterol and triglyeerides in the progeny were higher than in adult animals. Key Words: alimentary hypercholesterolemia; progeny; cholesterol; pregnancy; lactationThe role of hereditary factors in lipid metabolism in humans and animals has been extensively studied. Changes in blood content of lipids (hyperlipidemia) in the mother affects cholesterol (CS) homeostasis even if the child does not inherit hyperlipidemia. This problem received little attention, and contradictory results were obtained. We studied the effect of alimentary hypereholesterolemia (HCS) in rabbits during pregnancy and/or lactation on blood lipid levels in the progeny. MATERIALS AND METHODSThree groups of rabbits were studied. Group 1 (control, n=8) consisted of the progeny of 4 females fed standard diet; group 2 (n=8) consisted of the progeny of 6 females fed 0.5 g CS daily during the second half (15 days) of pregnancy and during lactation (30 days); and group 3 (n=8) included the progeny of 2 females fed CS in the same dose during lactation.Serum CS and triglycerides (TG) were measured in females with an AA-II autoanalyzer (Technicon) [2] before experiment and at the end of lactation and in their progeny at the age of 6, 15-20 weeks (period of sexual maturation), and 35-40 weeks (in adult

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The influence of cholesterol and fat in maternal diet of rats on the development of hepatic cholesterol metabolism in the offspring

Cited by 32 publications

References 19 publications

Effect of Chronic Modification of Diet Fat and Cholesterol during Gestation on Plasma Hormones and Hepatic Enzyme Activities in Rat Fetus

Effect of Chronic Modification of Diet Fat and Cholesterol during Gestation on Plasma Hormones and Hepatic Enzyme Activities in Rat Fetus

Famine Exposure during the Fetal Period Increased the Risk of Dyslipidemia in Female Adults

Effect of alimentary hypercholesterolemia in female rabbits on blood lipid levels in their progeny

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