The influence of cigarette smoking on a population of infertile men and women

Caserta, Donatella; Bordi, Giulia; Segni, Noemi Di; D’Ambrosio, A; Mallozzi, Maddalena; Mangino, Massimo

doi:10.1007/s00404-012-2643-5

Cited by 44 publications

(44 citation statements)

References 32 publications

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“…91,92 Pregnancy-related smoking consequences include infertility, spontaneous abortion, preterm delivery, and perinatal mortality. 9,89 These data again highlight the importance of measuring hormone levels when conducting smoking research in women. Using information about the association of the menstrual cycle to smoking to improve cessation outcomes for women may also have important consequences on improving menstrual cycle health.…”

mentioning

confidence: 94%

“…Smoking in women is associated with dysmenorrhea and menstrual irregularity 9,82 and altered ovarian cycle and hormone levels. 83,84 Compared to female nonsmokers, female smokers demonstrate changes in estrogen metabolism and lower circulating estrogen, 85,86 a shorter reproductive lifespan, 9,87,88 lower ovarian reserve, 89,90 and quicker entry into all stages of the menopausal transition. 91,92 Pregnancy-related smoking consequences include infertility, spontaneous abortion, preterm delivery, and perinatal mortality.…”

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confidence: 99%

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Systematic and Meta-Analytic Review of Research Examining the Impact of Menstrual Cycle Phase and Ovarian Hormones on Smoking and Cessation

Weinberger¹,

Smith

Allen

et al. 2015

Nicotine & Tobacco Research

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Introduction: To determine the effect of ovarian hormones on smoking, we conducted a systematic review of menstrual cycle effects on smoking (i.e., ad lib smoking, smoking topography, and subjective effects) and cessation-related behaviors (i.e., cessation, withdrawal, tonic craving, and cue-induced craving). Methods: Thirty-six papers were identified on MEDLINE that included a menstrual-related search term (e.g., menstrual cycle, ovarian hormones), a smoking-related search term (e.g., smoking, nicotine), and met all inclusion criteria. Thirty-two studies examined menstrual phase, 1 study measured hormone levels, and 3 studies administered progesterone. Results: Sufficient data were available to conduct meta-analyses for only 2 of the 7 variables: withdrawal and tonic craving. Women reported greater withdrawal during the luteal phase than during the follicular phase, and there was a nonsignificant trend for greater tonic craving in the luteal phase. Progesterone administration was associated with decreased positive and increased negative subjective effects of nicotine. Studies of menstrual phase effects on the other outcome variables were either small in number or yielded mixed outcomes. Conclusions: The impact of menstrual cycle phase on smoking behavior and cessation is complicated, and insufficient research is available upon which to conduct meta-analyses on most smoking outcomes. Future progress will require collecting ovarian hormone levels to more precisely quantify the impact of dynamic changes in hormone levels through the cycle on smoking behavior. Clarifying the relationship between hormones and smoking-particularly related to quitting, relapse, and medication response-could determine the best type and timing of interventions to improve quit rates for women.

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confidence: 94%

mentioning

confidence: 99%

Systematic and Meta-Analytic Review of Research Examining the Impact of Menstrual Cycle Phase and Ovarian Hormones on Smoking and Cessation

Weinberger¹,

Smith

Allen

et al. 2015

Nicotine & Tobacco Research

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“…Other studies did not find a significant alteration of conventional semen parameters in smokers [27,28]. Some others showed mixed results [29,30]. Soares and Melo [31] reviewed the literature on the relation between cigarette smoking and reproductive function and indicated that cigarette smoking has a negative effect on the male and female reproductive function.…”

Section: Introductionmentioning

confidence: 98%

Evaluation of the association of cigarette smoking with retention of excess cytoplasm by spermatozoa in infertile men

Hassanin¹,

El-Shirbini²

2015

Human Andrology

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PurposeThe aim of the study was to evaluate the effect of smoking on retention of excess cytoplasm by spermatozoa in infertile men. Patients and methods Two groups of idiopathic infertile men, group 1 (20 smokers) and group 2 (20 nonsmokers), were included in the study. The cytoplasmic droplet (CD)/defective CD was evaluated as an independent variable in Papanicolaou-stained seminal smears for each participant, in addition to the standard semen parameter. CD greater than onethird the sperm head size was considered defective [excess residual cytoplasm (ERC)]. ResultsDefective CD (ERC), total head defects, total tail defects, and total abnormal forms were significantly higher in the smoker group. Significant positive correlation was found between defective CD (ERC) and both the number of smoked cigarettes/day and the duration of smoking. Conclusion Retention of excess cytoplasm by spermatozoa may reflect the negative impact of cigarette smoking on sperm quality, function, and fertility potential in men. CD/ defective CD should be evaluated as an independent variable (parameter). We suggest that cutoff values of normality and abnormality of percentage of spermatozoa with CD and defective CD be clearly defined, as defective CDs not only affect the spermatozoa carrying them but may also affect the normal ones.

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“…However, smoking cessation has been associated with a decrease in testosterone levels [47,48]. Furthermore, when comparing sperm parameters between smokers and non-smokers, some studies showed a lower sperm concentration [49,50,51,52], lower total sperm count [50,51,52,53] and lower semen volume [51,52,54] in current smokers, while other studies demonstrated no effects on these parameters [55,56]. Recent in vitro work has shown that some of the compounds present in cigarettes are capable of decreasing AR activity [57], possibly by inhibition of DNA binding on androgen-responsive elements in target genes [58].…”

Section: Smokingmentioning

confidence: 99%

Androgen Receptor Genotype in Humans and Susceptibility to Endocrine Disruptors

Giwercman

2016

Horm Res Paediatr

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Although animal studies have raised concern that the influence of endocrine-disrupting compounds would obstruct the development of the male reproductive system, in general, exposure levels far above those found in humans have been needed to induce reproductive toxicity in animal models. Human data are inconclusive and have evoked the question whether endocrine-disrupting compounds can have any impact on hormonal function and thus health consequences when natural hormones are present. Indeed, many contaminants with hormone-like activity are much less potent than endogenous hormones themselves: 17β-oestradiol was, for instance, estimated to be 17,000 times more potent than o,p′-DDT. However, humans are exposed to a multitude of agents, and when present in sufficient number and concentration, they might in principle act collected on the actions of endogenous hormones. Whether such effects will be physiologically relevant is still not known. Nevertheless, in the worst-case scenario, there are no threshold levels below which there are no effects at all, and one target molecule is the androgen receptor. This mini review focuses on the androgen receptor gene, its link with classical endocrine disruptors and smoking, and how common genetic variants in the androgen receptor gene may influence physiological outcomes.

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The influence of cigarette smoking on a population of infertile men and women

Cited by 44 publications

References 32 publications

Systematic and Meta-Analytic Review of Research Examining the Impact of Menstrual Cycle Phase and Ovarian Hormones on Smoking and Cessation

Systematic and Meta-Analytic Review of Research Examining the Impact of Menstrual Cycle Phase and Ovarian Hormones on Smoking and Cessation

Evaluation of the association of cigarette smoking with retention of excess cytoplasm by spermatozoa in infertile men

Androgen Receptor Genotype in Humans and Susceptibility to Endocrine Disruptors

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