The influence of climate change on human cardiovascular function

Gostimirović, M.; Novaković, R; Rajković, Jovana; Djokic, Vladimir; Terzić, Duško; Putnik, Svetozar; Gojkovic-Bukarica, Ljiljana

doi:10.1080/19338244.2020.1742079

Cited by 70 publications

(52 citation statements)

References 26 publications

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“…These pathophysiologic pathways may be related to the development of stroke and increased risk of stroke mortality associated with long-term PM 2.5 exposure. In addition, extreme temperature variations plausibly contributed to cardiovascular damages by increasing amount of free radicals, inducing neuronal apoptotic signal transduction, and even elevating blood pressure and heart rate ( Gostimirovic et al, 2020 ). In future, we still need bio-molecular evidence supporting the specific and joint influences of long-term PM 2.5 pollution and temperature variation in cerebrovascular functions.…”

Section: Discussionmentioning

confidence: 99%

Long-term exposure to ambient PM2.5 and stroke mortality among urban residents in northern China

Yang

Zhang

Chen

et al. 2021

Ecotoxicology and Environmental Safety

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Evidence is still limited for the role of long-term PM 2.5 exposure in cerebrovascular diseases among residents in high pollution regions. The study is aimed to investigate the long-term effects of PM 2.5 exposure on stroke mortality, and further explore the effect modification of temperature variation on the PM 2.5 -mortality association in northern China. Based on a cohort data with an average follow-up of 9.8 years among 38,435 urban adults, high-resolution estimates of PM 2.5 derived from a satellite-based model were assigned to each participant. A Cox regression model with time-varying exposures and strata of geographic regions was employed to assess the risks of stroke mortality associated with PM 2.5 , after adjusting for individual risk factors. The cross-product term of PM 2.5 exposure and annual temperature range was further added into the regression model to test whether the long-term temperature variation would modify the association of PM 2.5 with stroke mortality. Among the study participants, the annual mean level of PM 2.5 concentration was 66.3 μg/m 3 ranging from 39.0 μg/m 3 to 100.6 μg/m 3 . For each 10 μg/m 3 increment in PM 2.5 , the hazard ratio (HR) was 1.31 (95% CI: 1.04–1.65) for stroke mortality after multivariable adjustment. In addition, the HRs of PM 2.5 decreased gradually as the increase of annual temperature range with the HRs of 1.95 (95% CI: 1.36–2.81), 1.53 (95% CI: 1.06–2.22), and 1.11 (95% CI: 0.75–1.63) in the low, middle, and high group of annual temperature range, respectively. The findings provided further evidence of long-term PM 2.5 exposure on stroke mortality in high-exposure settings such as northern China, and also highlighted the view that assessing the adverse health effects of air pollution might not ignore the role of temperature variations in the context of climate change.

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Section: Discussionmentioning

confidence: 99%

Long-term exposure to ambient PM2.5 and stroke mortality among urban residents in northern China

Yang

Zhang

Chen

et al. 2021

Ecotoxicology and Environmental Safety

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“…(2) people living in subtropical climate regions, such as Hunan province, central China, may have a higher sensitivity to cold weather and adaptability to hot temperatures (Liu et al 2020); and (3) exposure to cold temperatures can lead to increased blood pressure, blood viscosity, cardiac load, and serum low-density lipoprotein-cholesterol concentration, all of which contribute to cardiovascular mortality (Gostimirovic et al 2020;Hong et al 2012;Lim et al 2015;Yang et al 2015). Therefore, appropriate strategies should be established to reduce the mortality burden from the whole range of ambient temperatures.…”

Section: Discussionmentioning

confidence: 99%

Impact of ambient temperature on life loss per death from cardiovascular diseases: a multicenter study in central China

Zhou

Jin

et al. 2021

Environ Sci Pollut Res

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Background In the context of global climate change, studies have focused on the ambient temperature and mortality of cardiovascular diseases (CVDs). However, little is known about the effect of ambient temperature on year of life lost (YLL), especially the life loss per death caused by ambient temperature. In this study, we aimed to assess the relationship between ambient temperature and life loss and estimate the impact of ambient temperature on life loss per death. Methods We collected daily time series of mortality and meteorological data from 70 locations in Hunan province, central China, in periods ranging from Jan. 1, 2013, to Dec. 31, 2017. Crude rates of YLL were calculated per 100,000 people per year (YLL/100,000 population) for each location. A distributed lag nonlinear model and multivariate meta-regression were used to estimate the associations between ambient temperature and YLL rates. Then, the average life loss per death attributable to ambient temperature was calculated. Results There were 711,484 CVD deaths recorded within the study period. The exposure-response curve between ambient temperature and YLL rates was inverted J or U-shaped. Relative to the minimum YLL rate temperature, the life loss risk of extreme cold temperature lasted for 10 to 12 days, whereas the risk of extreme hot temperature appeared immediately and lasted for 3 days. On average, the life loss per death attributable to non-optimum ambient temperatures was 1.89 (95% CI, 1.21-2.56) years. Life loss was mainly caused by cold temperature (1.13, 95% CI, 0.89‑1.37), particularly moderate cold (1.00, 95% CI, 0.78‑1.23). For demographic characteristics, the mean life loss per death was relatively higher for males (2.07, 95% CI, 1.44‑2.68) and younger populations (3.72, 95% CI, 2.06‑5.46) than for females (1.88, 95% CI, 1.21-2.57) and elderly people (1.69, 95% CI, 1.28-2.10), respectively. Conclusions We found that both cold and hot temperatures significantly aggravated premature death from CVDs. Our results indicated that the whole range of effects of ambient temperature on CVDs should be given attention.

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“…An additional climate change‐related issue is the generation of heatwaves, which have been associated with both cardiovascular morbidity and mortality. [ 12 ] Mechanistically, impaired endothelial function likely significantly contributes to the disease outcomes. Moreover, hot weather impacts cytokine production and systemic inflammation which also adversely affect endothelial function.…”

Section: Acute Harm To Endothelium Caused By Climate Changementioning

confidence: 99%

Airborne particles and cardiovascular morbidity in severe inherited hypercholesterolemia: Vulnerable endothelium under multiple attacks

2021

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Despite recent advances in the research related to air pollution and associated adverse cardiovascular events, the combined effects of air pollution, climate change, and SARS‐CoV‐2 infection on cardiovascular health need to be researched further. This Commentary addresses their impacts on cardiovascular health in the approximately 25 million people with a severe form of inherited hypercholesterolemia, called familial hypercholesterolemia (FH). The arterial endothelium in these individuals is potentially under multiple attacks caused by particles of both endogenous and exogenous origin. Thus, they have a lifelong highly elevated level of circulating low density lipoprotein (LDL) cholesterol which drives premature atherosclerosis. The high levels of LDL particles, often associated with an elevated level of circulating lipoprotein(a) particles, are both capable of inducing and maintaining endothelial dysfunction. Such pre‐existing endothelial dysfunction can be exacerbated by exposure to SARS‐CoV‐2 viral particles, by exposure to fine particulate matter generated by climate change‐associated wildfires, and by dehydration during deadly heatwaves linked to the globally rising temperatures. The external factors can severely worsen the pre‐existing endothelial dysfunction, and thereby significantly increase the risk of a cardiovascular event in the exposed FH patients.

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The influence of climate change on human cardiovascular function

Cited by 70 publications

References 26 publications

Long-term exposure to ambient PM2.5 and stroke mortality among urban residents in northern China

Long-term exposure to ambient PM2.5 and stroke mortality among urban residents in northern China

Impact of ambient temperature on life loss per death from cardiovascular diseases: a multicenter study in central China

Airborne particles and cardiovascular morbidity in severe inherited hypercholesterolemia: Vulnerable endothelium under multiple attacks

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