The Influence of Collagen Impregnation of a Knitted Dacron Patch Used in Carotid Endarterectomy

Chou, Daisy; Tulloch, Allan W.; Cossman, David V.; Cohen, Jordan L.; Rao, Rajeev K.; Barmparas, Galinos; Mirocha, James; Wagner, Willis H.

doi:10.1016/j.avsg.2016.08.011

Cited by 12 publications

(9 citation statements)

References 24 publications

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“…From the autologous great saphenous vein graft to the commonly used prosthetic ePTFE and Dacron graft, each graft has its own merits and drawbacks (Bai et al, 2021c). Various modifications of these prosthetic grafts have been made, like heparin and rapamycin coating (Ambler and Twine, 2018;Baba et al, 2021) and collagen coating (Chou et al, 2017); these modification have contributed to the progress of vascular surgery. Along with the development of material science, new materials need to be tested for their application in vascular surgery.…”

Section: Discussionmentioning

confidence: 99%

A Novel Plant Leaf Patch Absorbed With IL-33 Antibody Decreases Venous Neointimal hyperplasia

Xie

Bai

Sun

et al. 2021

Front. Bioeng. Biotechnol.

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Introduction: We recently showed that a decellularized leaf scaffold can be loaded with polylactic-co-glycolic acid (PLGA)-based rapamycin nanoparticles, this leaf patch can then inhibit venous neointimal hyperplasia in a rat inferior vena cava (IVC) venoplasty model. IL-33 plays a role in the neointimal formation after vascular injury. We hypothesized that plant leaves can absorb therapeutic drug solution and can be used as a patch with drug delivery capability, and plant leaves absorbed with IL-33 antibody can decrease venous neointimal hyperplasia in the rat IVC venoplasty model.Method: A human spiral saphenous vein (SVG) graft implanted in the popliteal vein was harvested from a patient with trauma and analyzed by immunofluorescence. Male Sprague-Dawley rats (aged 6–8 weeks) were used to create the IVC patch venoplasty model. Plant leaves absorbed with rhodamine, distilled water (control), rapamycin, IL-33, and IL-33 antibody were cut into patches (3 × 1.5 mm2) and implanted into the rat IVC. Patches were explanted at day 14 for analysis.Result: At day 14, in the patch absorbed with rhodamine group, immunofluorescence showed rhodamine fluorescence in the neointima, inside the patch, and in the adventitia. There was a significantly thinner neointima in the plant patch absorbed with rapamycin (p = 0.0231) compared to the patch absorbed with distilled water. There was a significantly large number of IL-33 (p = 0.006) and IL-1β (p = 0.012) positive cells in the human SVG neointima compared to the human great saphenous vein. In rats, there was a significantly thinner neointima, a smaller number of IL-33 (p = 0.0006) and IL-1β (p = 0.0008) positive cells in the IL-33 antibody-absorbed patch group compared to the IL-33-absorbed patch group.Conclusion: We found that the natural absorption capability of plant leaves means they can absorb drug solution efficiently and can also be used as a novel drug delivery system and venous patch. IL-33 plays a role in venous neointimal hyperplasia both in humans and rats; neutralization of IL-33 by IL-33 antibody can be a therapeutic method to decrease venous neointimal hyperplasia.

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Section: Discussionmentioning

confidence: 99%

A Novel Plant Leaf Patch Absorbed With IL-33 Antibody Decreases Venous Neointimal hyperplasia

Xie

Bai

Sun

et al. 2021

Front. Bioeng. Biotechnol.

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“…В свою очередь, Dacron имеет высокую прочность и устойчивость к избыточному растяжению [9] [18]. Но по результатам, полученным другой научной группой, значимая разница по частоте тромбозов и рестенозов между группами с PTFE и Dacron, покрытого коллагеном, отсутствовала [19].…”

Section: виды сосудистых заплатunclassified

Vascular Patches for Arterial Reconstruction, Challenges and Advanced Technologies

Sevost'yanova

Миронов

Антонова

et al. 2019

Kompleks. probl. serdečno-sosud. zabol.

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High prevalence of internal carotid atherosclerosis and recent advances in its diagnosis result in an increase in the annual number of carotid endarterectomy procedures to restore carotid patency. Various randomized prospective studies as well as meta-analyses show a decrease in the number of perioperative and postoperative complications following carotid endarterectomy using patches compared with primary arterial closure. Despite the fact that the autologous vein is the material of choice for carotid patch angioplasty, xenogenic and synthetic patches are also widely used in the clinical practice. Furthermore, tissue engineering technologies and the development of novel biomaterials have recently emerged and may encourage manufacturing of vascular patches capable to promote a regenerative potential of the body and restore vascular wall tissues.

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“…Gelatin (denatured collagen), however, has been used to impregnate Dacron vascular grafts used in clinical practice, so as to make the material less permeable. This coating was not associated with increased thrombosis or restenosis (Chou et al, ). When thrombogenicity presents as a problem, the material can be coated with heparin to prevent blood clotting using the same carbodiimide cross‐linking step applied in this study (Lammers, van de Westerlo, Versteeg, van Kuppevelt, & Daamen, ).…”

Section: Introductionmentioning

confidence: 98%

Self-expandable tubular collagen implants

Versteegden

Meer

Lomme

et al. 2018

J Tissue Eng Regen Med

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Collagen has been extensively used as a biomaterial, yet for tubular organ repair, synthetic polymers or metals (e.g., stents) are typically used. In this study, we report a novel type of tubular implant solely consisting of type I collagen, suitable to self‐expand in case of minimal invasive implantation. Potential benefits of this collagen scaffold over conventional materials include improved endothelialization, biodegradation over time, and possibilities to add bioactive components to the scaffold, such as anticoagulants. Implants were prepared by compression of porous scaffolds consisting of fibrillar type I collagen (1.0–2.0% (w/v)). By applying carbodiimide cross‐linking to the compressed scaffolds in their opened position, entropy‐driven shape memory was induced. The scaffolds were subsequently crimped and dried around a guidewire. Upon exposure to water, crimped scaffolds deployed within 15–60 s (depending on the collagen concentration used), thereby returning to the original opened form. The scaffolds were cytocompatible as assessed by cell culture with human primary vascular endothelial and smooth muscle cells. Compression force required to compress the open scaffolds increased with collagen content from 16 to 32 mN for 1.0% to 2.0% (w/v) collagen scaffolds. In conclusion, we report the first self‐expandable tubular implant consisting of solely type I collagen that may have potential as a biological vascular implant.

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The Influence of Collagen Impregnation of a Knitted Dacron Patch Used in Carotid Endarterectomy

Cited by 12 publications

References 24 publications

A Novel Plant Leaf Patch Absorbed With IL-33 Antibody Decreases Venous Neointimal hyperplasia

A Novel Plant Leaf Patch Absorbed With IL-33 Antibody Decreases Venous Neointimal hyperplasia

Vascular Patches for Arterial Reconstruction, Challenges and Advanced Technologies

Self-expandable tubular collagen implants

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