The Influence of Colloid Osmotic Pressure on Hydrostatic Pressures in High‐ and Low‐Flux Hemodialyzers

Schneditz, Daniel; Sarikakis, Georgios; Kontodima, Maria; Sauseng, Notburga

doi:10.1111/aor.13081

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…In contrast to HES, it also reduces the viscosity of the blood, unblocks the microcirculation, and facilitates oxygen delivery and cytokine metabolism, thus improving organ function. Colloids are large in molecular weight, which are effective in maintaining the simplified osmotic pressure of plasma [ 30 ]. Colloids hardly get through cell membranes, leading to dehydration of red blood cells, and early colloidal rehydration aggravates tissue hypoxia and affects coagulation [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Different Types of Early Restrictive Fluid Resuscitation on Immune Function and Multiorgan Damage on Hemorrhagic Shock Rat Model in a Hypothermic Environment

Xu¹,

Zu³

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. This study was aimed at investigating the effects of different types of fluid restriction fluid resuscitation on the immune dysfunction and organ injury of hemorrhagic shock rats under a hypothermic environment. Methods. SD rats were divided into sham operation group (SHAM), hemorrhagic shock model group (HS), crystal liquid limited resuscitation group (CRLLR), colloidal liquid limited resuscitation group (COLLR), and nonlimited resuscitation group (NLR); rats in each group were placed in a low-temperature environment of 0-5°C for 30 min, and then, a hemorrhagic shock rat model was prepared. Sodium lactate Ringer’s restricted resuscitation solution, hydroxyethyl starch restricted resuscitation solution, and hydroxyethyl starch were used for resuscitation, and hemodynamic examination was performed. The mortality rate, inflammatory factors, oxidative stress factors, and immune function were detected by ELISA. The dysfunction and injury of the intestinal, lung, liver, and kidney were examined by histological methods. Results. Hemorrhagic shock resulted in decreased immune function and activation of inflammation. Unrestricted fluid infusion further activated the inflammatory response. The crystalloid-restricted fluid infusion performed effectively to regulate inflammatory response, promote antioxidative activity, and reduce the immunosuppressive reaction. Rehydration could regulate the coagulation. The hydroxyethyl starch reduced the expression of platelet glycoproteins Ib and IIb/IIIa and blocked the binding of fibrinogen to activated platelets, thereby inhibiting intrinsic coagulation and platelet adhesion and aggregation. Rats in the CRLLR group showed to relieve the injury of the lung, liver, kidney, and intestine from hemorrhagic shock in low-temperature environment. Conclusion. The early application of restrictive crystalloid resuscitation in hemorrhagic shock rats in hypothermic environment showed the best therapy results. Early LR-restrictive fluid replacement promotes the balance of inflammatory response and the recovery of immunosuppressive state, resists oxidative stress, stabilizes the balance of coagulation and fibrinolysis, improves coagulation function, and relieves organ injury.

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Section: Discussionmentioning

confidence: 99%

Effects of Different Types of Early Restrictive Fluid Resuscitation on Immune Function and Multiorgan Damage on Hemorrhagic Shock Rat Model in a Hypothermic Environment

Xu¹,

Zu³

et al. 2022

Computational and Mathematical Methods in Medicine

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“…Daniel Schneditz et al of the Medical University of Graz, Graz, Austria, investigated the relationship between hydrostatic trans‐membrane pressure (TMPh) and colloid osmotic pressure (COP) in low‐flux (LF) and high‐flux (HF) dialyzers. The TMPh to blood flow relationship measured in dialyzers in the absence of ultrafiltration can be described by the intercept related to measured COP and the slope related to internal filtration.…”

Section: Renal Support and Dialysismentioning

confidence: 99%

Artificial Organs 2018: A Year in Review

Malchesky¹

2019

Artificial Organs

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In this Editor's Review, articles published in 2018 are organized by category and summarized. We provide a brief reflection of the research and progress in artificial organs intended to advance and better human life while providing insight for continued application of these technologies and methods. Artificial Organs continues in the original mission of its founders “to foster communications in the field of artificial organs on an international level.” Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ Replacement, Recovery, and Regeneration from all over the world. Peer‐reviewed special issues this year included contributions from the 13th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion edited by Dr. Akif Undar, and the 25th Congress of the International Society for Mechanical Circulatory Support edited by Dr. Marvin Slepian. Additionally, many editorials highlighted the worldwide survival differences in hemodialysis and perspectives on mechanical circulatory support and stem cell therapies for cardiac support. We take this time also to express our gratitude to our authors for offering their work to this journal. We offer our very special thanks to our reviewers who give so generously of time and expertise to review, critique, and especially provide meaningful suggestions to the author's work whether eventually accepted or rejected. Without these excellent and dedicated reviewers the quality expected from such a journal could not be possible. We also express our special thanks to our Publisher, John Wiley & Sons for their expert attention and support in the production and marketing of Artificial Organs. We look forward to reporting further advances in the coming years.

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Determinants of Hemodialysis Performance:Modeling Fluid and Solute Transport in Hollow-Fiber Dialyzers

Chitalia

Akintewe

et al. 2019

Regen. Eng. Transl. Med.

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The Influence of Colloid Osmotic Pressure on Hydrostatic Pressures in High‐ and Low‐Flux Hemodialyzers

Cited by 4 publications

References 30 publications

Effects of Different Types of Early Restrictive Fluid Resuscitation on Immune Function and Multiorgan Damage on Hemorrhagic Shock Rat Model in a Hypothermic Environment

Effects of Different Types of Early Restrictive Fluid Resuscitation on Immune Function and Multiorgan Damage on Hemorrhagic Shock Rat Model in a Hypothermic Environment

Artificial Organs 2018: A Year in Review

Determinants of Hemodialysis Performance:Modeling Fluid and Solute Transport in Hollow-Fiber Dialyzers

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