The influence of COPD on health-related quality of life independent of the influence of comorbidity

Manen, Jeannette G. van; Bindels, Patrick J E; Dekker, Friedo W.; Bottema, Ben; Zee, Jaring S. van der; IJzermans, C.J.; Schadé, E

doi:10.1016/s0895-4356(03)00208-7

Cited by 100 publications

(85 citation statements)

References 23 publications

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“…The SF-36 physical and mental component scores for patients with LAM are worse than those for the general U.S. healthy population with no chronic conditions (55.3 and 53.4, respectively) but better than those for patients with COPD seen in one study with a mean FEV 1 of 45% predicted (35.9 and 47.7, respectively) (26,39). Interestingly, the lack of physiologic correlation with the SF-36 mental component, which is similar to patients with COPD (38,40), suggests both groups develop coping mechanisms or have good support systems.…”

Section: Discussionmentioning

confidence: 90%

The NHLBI Lymphangioleiomyomatosis Registry

Ryu

Moss

Beck

et al. 2006

Am J Respir Crit Care Med

414

178

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Rationale: Pulmonary lymphangioleiomyomatosis is a progressive cystic lung disease that is associated with infiltration of atypical smooth muscle-like cells. Previous descriptions of clinical characteristics of subjects with lymphangioleiomyomatosis have been based on a limited number of patients. Objectives: To describe the clinical characteristics of subjects with pulmonary lymphangioleiomyomatosis, both sporadic and tuberous sclerosis-related forms. Methods: Over a 3-yr period, from 1998 to 2001, 243 subjects with pulmonary lymphangioleiomyomatosis were enrolled into a national registry; 13 subjects who had already undergone lung transplantation were excluded for the purposes of this report. Measurements and Main Results: All 230 subjects were women, aged 18 to 76 yr (mean Ϯ SE, 44.5 Ϯ 0.65 yr). The average age at onset of symptoms was 38.9 Ϯ 0.73 yr and at diagnosis was 41.0 Ϯ 0.65 yr. Tuberous sclerosis complex was present in 14.8% of subjects. Pulmonary manifestations, most commonly spontaneous pneumothorax, were the primary events leading to the diagnosis in 86.5% of cases. Nearly 55% of the subjects were being treated with a progesterone derivative. An obstructive pattern on pulmonary function testing was observed in 57.3% of the subjects, whereas 33.9% had normal spirometric results. Women with tuberous sclerosis-related lymphangioleiomyomatosis were younger and had less impaired lung function compared with those with the sporadic form. Conclusions: The age range of women afflicted with pulmonary lymphangioleiomyomatosis is broader than previously appreciated and the degree of pulmonary function can be quite variable, with one-third of subjects having normal spirometry at enrollment into this registry.

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Section: Discussionmentioning

confidence: 90%

The NHLBI Lymphangioleiomyomatosis Registry

Ryu

Moss

Beck

et al. 2006

Am J Respir Crit Care Med

414

178

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“…Concurring with our findings, Wijnhoven et al [4] reported that comorbid diseases significantly contributed to all domains of HRQOL in patients with COPD. Van Manen et al [26] suggested that impairment in social and emotional functioning in patients with COPD did not seem to be related to COPD, only to comorbid pathologies.…”

Section: Discussionmentioning

confidence: 99%

Health-Related Quality of Life in Community-Dwelling Men with Pneumoconiosis

Tang¹,

Lum²,

Ungvari³

et al. 2006

Respiration

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Background: There have been few data on the health-related quality of life (HRQOL) in patients with pneumoconiosis. HRQOL is an important aspect of daily living in patients with industrial diseases. Objectives: To investigate the HRQOL and factors that contribute to the impairment of HRQOL in patients with pneumoconiosis. Methods: 297 patients with pneumoconiosis were recruited from a community-based case registry. The HRQOL was measured with the St. George’s Respiratory Questionnaire (SGRQ). Pulmonary function, comorbidity and psychosocial variables were also assessed. Patients’ mood state was evaluated with the Geriatric Depression Scale (GDS). Results: The mean SGRQ symptom, activity, impact and total scores were 38.0 ± 19.3, 44.5 ± 21.9, 34.2 ± 17.9 and 39.4 ± 17.4, respectively. These figures were lower than those reported in patients with chronic obstructive pulmonary disease who attended chest clinics. The GDS score (r = 0.38), forced expiratory volume in 1 s predicted (FEV₁% predicted;r = –0.33) and comorbidity (r = 0.21) were the most important predictors of the HRQOL. Conclusions: Besides lung functions, chest clinicians should consider the impact of mood symptoms and comorbidity on the HRQOL in the management of patients with pneumoconiosis.

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“…COPD patients suffer from a high proportion of comorbid conditions [8][9][10][11] and up to two-thirds of individuals suffering from COPD die of non-pulmonary causes [12,13]. Comorbidities also influence important patient-centred outcomes, such as health status [14,15], response to therapeutic intervention [16], and frequent hospital readmissions [17,18]. The majority of studies of COPD comorbidities report the relationship between a single or small number of comorbidities [19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

COPD comorbidities network

et al. 2015

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Multimorbidity frequently affects the ageing population and their co-existence may not occur at random. Understanding their interactions and that with clinical variables could be important for disease screening and management.In a cohort of 1969 chronic obstructive pulmonary disease (COPD) patients and 316 non-COPD controls, we applied a network-based analysis to explore the associations between multiple comorbidities. Clinical characteristics (age, degree of obstruction, walking, dyspnoea, body mass index) and 79 comorbidities were identified and their interrelationships quantified. Using network visualisation software, we represented each clinical variable and comorbidity as a node with linkages representing statistically significant associations.The resulting COPD comorbidity network had 428, 357 or 265 linkages depending on the statistical threshold used ( p⩽0.01, p⩽0.001 or p⩽0.0001). There were more nodes and links in COPD compared with controls after adjusting for age, sex and number of subjects. In COPD, a subset of nodes had a larger number of linkages representing hubs. Four sub-networks or modules were identified using an interlinkage affinity algorithm and their display provided meaningful interactions not discernible by univariate analysis.COPD patients are affected by larger number of multiple interlinked morbidities which clustering pattern may suggest common pathobiological processes or be utilised for screening and/or therapeutic interventions. @ERSpublications COPD patients are affected by interlinked comorbidities forming structured networks

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The influence of COPD on health-related quality of life independent of the influence of comorbidity

Cited by 100 publications

References 23 publications

The NHLBI Lymphangioleiomyomatosis Registry

The NHLBI Lymphangioleiomyomatosis Registry

Health-Related Quality of Life in Community-Dwelling Men with Pneumoconiosis

COPD comorbidities network

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