The influence of corticosteroids on the release of novel biomarkers in human endotoxemia

Kruif, Martijn D. de; Lemaire, L.C.J.M.; Giebelen, Ida A. J.; Struck, Joachim; Morgenthaler, Nils G.; Papassotiriou, Jana; Elliott, Peter J.; Poll, Tom van der

doi:10.1007/s00134-007-0955-x

Cited by 98 publications

(68 citation statements)

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“…29 An advantage of procalcitonin over other biomarkers is that its production is not significantly affected by nonsteroidal or steroidal anti-inflammatory drugs. [30][31][32] Our study has several limitations. The sample size was small and caution should be used when interpreting the results.…”

Section: Discussionmentioning

confidence: 99%

Plasma concentrations of copeptin, C-reactive protein and procalcitonin are positively correlated with APACHE II scores in patients with sepsis

et al. 2015

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Objective: To evaluate the correlation between Acute Physiology and Chronic Health Evaluation II (APACHE II) score and plasma concentrations of copeptin, C-reactive protein (CRP) and procalcitonin in patients with sepsis. Methods: Patients with sepsis were prospectively enrolled. APACHE II scores were determined during the first 24 h after admission to the intensive care unit. Plasma copeptin, CRP and procalcitonin were quantified at admission, 24 h, 48 h, and 72 h. Survival at 28 days after admission was recorded. Results: APACHE II score was significantly positively correlated with plasma copeptin, CRP and procalcitonin concentrations. Survivors (n ¼ 15) had significantly lower APACHE II scores and copeptin, CRP and procalcitonin concentrations than nonsurvivors (n ¼ 26). APACHE II score, copeptin at 72 h, CRP at 48 h and procalcitonin at 24 h were independent risk factors for death. Conclusion: Plasma copeptin, CRP and procalcitonin concentrations were positively correlated with APACHE II score in patients with sepsis, and reflected disease severity.

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Section: Discussionmentioning

confidence: 99%

Plasma concentrations of copeptin, C-reactive protein and procalcitonin are positively correlated with APACHE II scores in patients with sepsis

et al. 2015

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“…34 One attractive aspect of PCT is that its level is not influenced by corticosteroid use. 35 In a study 36 with 102 critically ill patients with systemic bacterial infections receiving parenteral prednisolone 20-1500 mg/day, while appropriately high PCT levels were observed, significantly lower levels of CRP and IL-6 were observed. 36 …”

Section: Neutropenic And/or Immunosuppressed Patientsmentioning

confidence: 97%

Procalcitonin in sepsis and bacterial infections

Chaudhury¹,

Sumant²,

Jayaprada³

et al. 2013

JCSR

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The differentiation of sepsis and systemic bacterial infections from other causes of systemic inflammatory response is crucial from the therapeutic point of view. The clinical signs and symptoms are non-specific and traditional biomarkers like white cell count, erythrocyte sedimentation rate and C-reactive protein are not sufficiently sensitive or specific to guide therapeutic decisions. Procalcitonin (PCT) is considered a reliable marker for the diagnosis and prognosis of moderate to severe bacterial infections, and it has also been evaluated to guide the clinicians in the rational usage of antibiotics. This review describes the diagnostic and prognostic role of PCT as a biomarker in various clinical settings along with the laboratory aspects and its usefulness in risk stratification and antibiotic stewardship.

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“…Так, прием глюкокор-тикоидов существенно не влиял на уровень ПК. В то же время имеются данные о том, что при длитель-ном использовании высоких доз глюкокортикоидов О б з о р ы уровень ПК имеет тенденцию к снижению [38,[42][43][44][45][46]. Иммуносупрессоры и некоторые биологические пре-параты (ингибиторы фактора некроза опухоли α, ин-терлейкин 6, ритуксимаб) также не оказывали влияния на уровень ПКТ крови [43,47,48].…”

Section: болезнь стилла взрослыхunclassified