The influence of deferiprone (L1) and deferoxamine on iron and essential element tissue level and parameters of oxidative status in dietary iron-loaded mice

Posterior subcapsular opacity in two patients with thalassaemia major following deferiprone consumption

“…8 There, it could decrease the activity of the enzyme glutathione peroxidase, which subsequently may cause lenticular opacities. 9,10 In addition, the deferiprone-iron complex may ultrafiltrate through the thinner posterior capsule and deposit in the adjacent cortex.…”

The efficacy of deferiprone on tissues aluminum removal and copper, zinc, manganese level in rabbits

“…The current experiment clearly demonstrated that the elimination of essential trace element copper, zinc and manganese have not been increased in rabbits. However, the administration of DFO to standard diet fed animals caused a significant decrease of zinc and copper concentration in the liver tissue [26].…”

Neurological Complications and Cataract in a Child With Thalassemia Major Treated With Deferiprone

“…12 Thus, DFP may achieve high levels in the aqueous humor where it may decrease the activity of the enzyme glutathione peroxidase leading to lenticular opacities. 13,14 In conclusion, clinicians should be alert to the occurrence of neurological and ocular abnormalities during DFP therapy. As with DFO therapy, periodic ophthalmologic evaluation should be undertaken in children on DFP therapy as well.…”