The Influence of Diabetes Mellitus on Sodium Homeostasis in Patients with Preserved Ejection Fraction Heart Failure

Abstract

The objective of the study was to analyze the characteristics of the patients with preserved ejection fraction heart failure (HfpEF) who develop hyponatremia, in relationship with the diabetes mellitus (DM). The current study is an observational retrospective one, that included 36 patients(25 women, 11 men), aged 66.6� 3.1 years, hospitalized for decompensated chronic heart failure, with a left ventricular ejection fraction ]40%. 33% (n=12) of the enrolled patients had hyponatremia, which was strong associated with DM (75% vs 17%, p[0.0005). In hyponatremic patients group was no association between DM and age, gendre, smoking, artrial hypertension, dyslipidemia, ejection fraction distribution or NTproBNP. As for medication at admission, we found an association of the presence of DM with betablockers(100% vs 67%, p[0.05) and with statins( 89% vs 67%, p[0.05). In our study, DM and non-DM patients with low serum sodium values and HfpEF have quite similar clinical profile, since the differences we found do not explain the high prevalence of DM in hyponatremic patients. As a conclusion, the presence of DM itself may explain the high prevalence of DM in hyponatremic patients, but is necessary to have larger studies with more variables included to assess HFpEF patients with DM and hyponatremia.

The Acute Hemodynamic Effects of Caffeine During Different Body Positions in Normotensive Young Adults

“…To take into account the postural, gravitationally induced effects on BP, it should be mentioned that the head-down Trendelenburg position leads to a temporary increase of venous return and preload, cardiac output and perfusion index [28]. Certainly, the stroke volume variation is subjected to the body posture [29,30], but the pressure hemodynamic effects, especially in people with hypotension, heart failure or aortic stenosis are the subject of dispute between various authors [31][32][33]. In clinical practice, the Trendelenburg position is used mainly with small or medium angles of inclination, in which there is no significant influence in the dominant parasympathetic cardiac control [34].…”

The Effects of Whole Body Vibration on Body Composition and Lipid Profile in Healthy Young Adults

“…To establish the criteria for inclusion and exclusion of the subjects in the experimental group, we used specialized psychological support. Thus, we selected healthy, normal-weight young subjects (21-25 years old), without present morbidity (diabetes, especially with complications, oncological disease) [10][11][12][13], with stable eating patterns, without a history of bulimia, anorexia, recent diets or other psychological disorders that interfere with the nutritional status. Also, only subjects who showed compliance with maintaining the lifestyle during the experiment in terms of nutrition, physical activity regime, and exposure to daily stress were included.…”

Transtoracical Ecocardiographic Assessment of Severe Degenerative Aortic Stenosis with Normal Ejection Fraction and Low Transvalvular Gradient

“…The inclusion criteria in the study were severe degenerative aortic stenosis and EF greater than 50%. Exclusion criteria were: aortic/rheumatic stenosis, moderate-severe associated valvulopathies, ischemic coronary disease, acute coronary syndromes, primitive pulmonary hypertension, rhythm and conduct disorders, absence of sinus rhythm, primary and/or secondary sinus disease, pericarditis, oncological diseases during chemotherapy, [33] heart, respiratory and renal failure, [34] hemoglobin less than 10g/dL [35], decompensated metabolic diseases, presence of skin lesions, with overadded infections or multi-resistant germ infections [36][37][38][39][40][41][42][43][44]. The patients were evaluated clinically and paraclinically, it was noted the presence of cardiovascular risk factors, the presence of symptoms, and pharmacological treatment given to the patients.…”