The Influence of Diabetes Mellitus and Insulin Therapy on Biomechanical Retention Around Dental Implants: A Study in Rabbits

Margonar, Rogério; Sakakura, Celso Eduardo; Holzhausen, Marinella; Pepato, Maria Teresa; Alba, júnior Rodolfo Cândia; Marcantonio, júnior Elcio

doi:10.1097/01.id.0000086482.65273.b7

Cited by 60 publications

(62 citation statements)

References 15 publications

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“…In the present study, serum from diabetic rabbits induced osteoblast dysfunction after seeding cells alongside titanium implants for 7 days. These findings are in accordance with several experimental studies that revealed an impaired bone healing response to implant placement in diabetic animals compared to non-diabetic controls [26,27]. Several mechanisms have been proposed, including impaired tissue integration, increased foreign body reaction, and oxidative environment surrounding the implants [28,29], but none have been definitively proven.…”

Section: Discussionsupporting

confidence: 93%

Insulin improves osteogenesis of titanium implants under diabetic conditions by inhibiting reactive oxygen species overproduction via the PI3K-Akt pathway

et al. 2015

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Section: Discussionsupporting

confidence: 93%

Insulin improves osteogenesis of titanium implants under diabetic conditions by inhibiting reactive oxygen species overproduction via the PI3K-Akt pathway

et al. 2015

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“…The observed discrepancy may be attributed to different models of endosseous implantation, i.e. With regard to the effect of experimental diabetes on the biomechanical properties of endosseous implants, reduced removal torque values have been observed at 8 and 12 weeks postimplantation (Margonar et al 2003). smooth vs. rough.…”

Section: Preclinical Studiesmentioning

confidence: 97%

The effect of diabetes mellitus on osseous healing

Retzepi

Donos

2010

Clinical Oral Implants Res

184

138

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Diabetes mellitus and, in particular, type 1 diabetes has been associated with impaired osseous wound healing properties. The scope of the present review is to discuss the clinical evidence supporting a higher rate of complications during fracture healing in diabetic patients and the histological evidence indicating impaired potential for intramembranous and endochondral ossification in the presence of uncontrolled experimental diabetes. The article further provides a synthesis of our current understanding of the plausible molecular mechanisms underlying the diabetic bone healing pathophysiology and of the role of insulin treatment in promoting osseous healing in the diabetic status.

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“…The rabbits from the control group and the DM group were injected with a sterile saline solution 17 .…”

Section: Insulin Treatmentmentioning

confidence: 99%

Insulin promotes bone formation in augmented maxillary sinus in diabetic rabbits

Hou

Liu

et al. 2012

International Journal of Oral and Maxillofacial Surgery

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The Influence of Diabetes Mellitus and Insulin Therapy on Biomechanical Retention Around Dental Implants: A Study in Rabbits

Cited by 60 publications

References 15 publications

Insulin improves osteogenesis of titanium implants under diabetic conditions by inhibiting reactive oxygen species overproduction via the PI3K-Akt pathway

Insulin improves osteogenesis of titanium implants under diabetic conditions by inhibiting reactive oxygen species overproduction via the PI3K-Akt pathway

The effect of diabetes mellitus on osseous healing

Insulin promotes bone formation in augmented maxillary sinus in diabetic rabbits

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