The Influence of Diabetes on the Relationship between <i>N</i>-terminal Pro-B-type Natriuretic Peptide and Body Mass Index

Bh, Kim; Ij, Kim; Ki, Cho; Kim, Seon Mee; Hg, Lee; Ti, Kim

doi:10.1177/147323001003800519

Cited by 5 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A negative relationship between plasma BDNF levels and obesity has been described in other studies 23–28. These results show that there is an inverse relationship between BDNF levels and BMI.…”

Section: Discussionsupporting

confidence: 84%

Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?

Güzel¹,

Bakkal²,

Güzel³

et al. 2014

NDT

View full text Add to dashboard Cite

ObjectiveDepression is a common condition in obese women that can result in severe impairment of their physical and social functioning. A deficiency of brain-derived neurotrophic factor (BDNF) is involved in the mechanism of depression. The aim of this study is to investigate whether BDNF levels differ between obese female patients and healthy controls and whether BDNF levels alter with affective states in depressive obese women.MethodsThe study group included 40 obese, 40 preobese, and 40 normal weight women. BDNF levels were measured with an enzyme-linked immunosorbent assay in patient and control groups. For identifying the depression and anxiety status, Beck Depression/Anxiety Inventories were used; and for the evaluation of cognitive functions, the mini-mental state examination was used.ResultsBDNF levels were significantly lower in obese patients compared to the control group (P<0.01). BDNF levels were significantly lower in obese patients with depression compared to the obese patients without depression (P<0.05). The Beck Depression Inventory showed a negative correlation with BDNF (r=−0.044; P<0.01) and a positive correlation with the Beck Anxiety Inventory (r=0.643; P<0.001), vitamin B12 levels (r=0.023; P<0.001), and insulin levels (r=0.257; P<0.05) in obese patients. When receiver operating characteristic curve analysis was used to analyze the suitability of BDNF to identify depression in obese women, the area under the curve for BDNF, 0.756, was found to be significant (P=0.025). BDNF levels lower than 70.2 pg/mL were associated with a higher prevalence of depressive symptoms.ConclusionThe results of our study suggest that the decrease in BDNF levels can be used as a marker for depression diagnosis in obese patients.

show abstract

Section: Discussionsupporting

confidence: 84%

Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?

Güzel¹,

Bakkal²,

Güzel³

et al. 2014

NDT

View full text Add to dashboard Cite

show abstract

“…The natriuretic system and adiposity are closely linked. Natriuretic peptides have been shown to be important stimuli for lipolysis in humans, which is similar in potency to catecholamines, and their effect is independent of both catecholamines and insulin pathway [22]–[23]. Cardiac natriuretic peptides have emerged as potent metabolic hormones.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Age and NT-proBNP on the Association of Central Obesity with 6-Years Cardiovascular Mortality of Middle-Aged and Elderly Diabetic People: The Population-Based Casale Monferrato Study

et al. 2014

View full text Add to dashboard Cite

BackgroundAmong people with type 2 diabetes the relationship between central obesity and cardiovascular mortality has not been definitely assessed. Moreover, NT-proBNP is negatively associated with central obesity, but no study has examined their combined effect on survival. We have examined these issues in a well-characterized population-based cohort.Methods and FindingsSurvival data of 2272 diabetic people recruited in 2000 who had no other chronic disease have been updated to 31 December 2006. NT-proBNP was measured in a subgroup of 1690 patients. Cox proportional hazards modeling was employed to estimate the independent associations between cardiovascular and all-cause mortality and waist circumference. Mean age was 67.9 years, 49.3% were men. Both age and NT-proBNP were negatively correlated with waist circumference (r = −0.11, p<0.001 and r = −0.07, p = 0.002). Out of 2272 subjects, 520 deaths (221 for CV mortality) occurred during a median follow-up of 5.4 years. Central obesity was not associated with CV mortality (hazard ratio, HR, adjusted for age, sex, diabetes duration, 1.14, 95% CI 0.86–1.52). NTproBNP was a negative confounder and age a strong modifier of this relationship (p for interaction<0.001): age<70 years, fully adjusted model HR = 3.52 (1.17–10.57) and age ≥70 years, HR = 0.80 (0.46–1.40). Respective HRs for all-cause mortality were 1.86 (1.03–3.32) and 0.73 (0.51–1.04).ConclusionsIn diabetic people aged 70 years and lower, central obesity was independently associated with increased cardiovascular mortality, independently of the negative effect of NT-proBNP. In contrast, no effect on 6-years survival was evident in diabetic people who have yet survived up to 70 years.

show abstract

“…Secondly, the diagnosis and classification of HF by NYHA class were determined by the treating physician and were not confirmed independently. Finally, NT-proBNP concentration may be influenced by factors other than heart disease, such as diabetes mellitus 27,28 or body weight, 27,28 but no adjustment was made for such confounding factors.…”

mentioning

confidence: 99%

Predicting the Risk of Venous Thromboembolism in Patients Hospitalized With Heart Failure

et al. 2014

View full text Add to dashboard Cite

Background-Whether heart failure (HF) increases the risk of venous thromboembolism (VTE) is not well established.In the phase III MAGELLAN (Multicenter, rAndomized, parallel Group Efficacy and safety study for the prevention of venous thromboembolism in hospitalized medically iLL patients comparing rivaroxabAN with enoxaparin) trial, extended-duration rivaroxaban was compared with standard-duration enoxaparin followed by placebo for VTE prevention in 8101 hospitalized acutely ill patients with or without HF. The aim of this analysis was to evaluate the relationship between HF severity and the risk of VTE in MAGELLAN patients. Methods and Results-Hospitalized patients diagnosed with HF were included according to New York Heart Association class III or IV at admission (n=2593). HF severity was determined by N-terminal probrain natriuretic peptide (NT-proBNP) plasma concentrations (median 1904 pg/mL). Baseline plasma D-dimer concentrations ranged from 0.6 to 1.7 μg/L for the less and more severe HF subgroups. Patients with more severe HF had a greater incidence of VTE versus patients with less severe HF, with a significant trend up to

show abstract

The Influence of Diabetes on the Relationship between N-terminal Pro-B-type Natriuretic Peptide and Body Mass Index

Abstract: This study evaluated the influence of diabetes on the relationship between Nterminal pro-B-type natriuretic peptide (NT-proBNP) and body mass index (BMI

Cited by 5 publications

References 33 publications

Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?

Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?

The Effect of Age and NT-proBNP on the Association of Central Obesity with 6-Years Cardiovascular Mortality of Middle-Aged and Elderly Diabetic People: The Population-Based Casale Monferrato Study

Predicting the Risk of Venous Thromboembolism in Patients Hospitalized With Heart Failure

Contact Info

Product

Resources

About

The Influence of Diabetes on the Relationship between N-terminal Pro-B-type Natriuretic Peptide and Body Mass Index

Abstract: This study evaluated the influence of diabetes on the relationship between Nterminal pro-B-type natriuretic peptide (NT-proBNP) and body mass index (BMI

Cited by 5 publications

References 33 publications

Can low brain-derived neurotrophic factor levels&nbsp;be a marker of the presence of depression in&nbsp;obese women?

Can low brain-derived neurotrophic factor levels&nbsp;be a marker of the presence of depression in&nbsp;obese women?

The Effect of Age and NT-proBNP on the Association of Central Obesity with 6-Years Cardiovascular Mortality of Middle-Aged and Elderly Diabetic People: The Population-Based Casale Monferrato Study

Predicting the Risk of Venous Thromboembolism in Patients Hospitalized With Heart Failure

Contact Info

Product

Resources

About

Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?

Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?