The influence of different glucose tolerance on QTc interval: a population-based study

Abstract

Background Corrected QT (QTc) interval has been reported to be associated with type 2 diabetes. This study aimed to explore the relationship between different glucose tolerance and QTc interval among middle-aged and older Chinese individuals. Methods We conducted a cross-sectional analysis that included 9898 subjects (3194 men and 6704 women) in a Chinese population. Glucose tolerance was studied during OGTT. Insulin, blood pressure, HbA1c, serum lipids, hepatic transaminases and waist-to-hip ratio were assessed.The QTc interval was derived from ECG recordings, and the subjects were stratified based on different glucose tolerance. Results QTc interval levels were increased significantly in the subjects with abnormal glucose metabolism compared with the normal glucose regulation group. Multiple regression analyses QTc interval was significantly associated with fasting plasma glucose, 2-h OGTT plasma glucose and HbA1c. The odds ratios of prolonged QTc was 1.396 for IFG/IGT (95% CI: 0.126-1.730), 1.342 for type 2 diabetes (95% CI: 0.142-1.577) after all the potential confounders were adjusted. Conclusions IGR and diabetes are associated with prolonged QTc interval among middle-aged and older Chinese individuals. Abnormal glucose regulation can be used to monitor QTc interval in the population.