The influence of different InsP3 receptor isoforms on Ca2+ signaling in tracheal smooth muscle cells

Haberichter, Thomas; Roux, Étienne; Marhl, Marko; Mazat, Jean‐Pierre

doi:10.1016/s1567-5394(02)00063-4

Cited by 14 publications

(14 citation statements)

References 39 publications

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“…Moreover, a detailed examination and analysis of the model presented by Haberichter et al [2] shows that the pattern of Ca 2+ oscillations is far from experimentally observed oscillations, especially at larger IP 3 concentrations. That is mostly due to a plateau, i.e.…”

Section: Model Predictions and Discussionmentioning

confidence: 85%

“…It is worthwhile to compare our model with the model of Ca 2+ oscillations in airway smooth muscle cell proposed by Haberichter et al [2]. The latter is a closed model with respect to Ca 2+ , as no exchange with extracellular medium is included in the model.…”

Section: Model Predictions and Discussionmentioning

confidence: 96%

“…The complete list of the model parameters also shows some other differences in the values chosen in comparison to those used by the model of Haberichter et al [2]. The main differences are, roughly speaking, in faster exchange of Ca 2+ with Ca 2+ binding proteins, higher total concentration of proteins in the cytosol, higher SR Ca 2+ -ATPase activity and larger IP 3 R channel density.…”

Section: Model Predictions and Discussionmentioning

confidence: 99%

“…The sarcoplasmic reticulum (SR) and the Ca 2+ binding cytosolic proteins serve as intracellular Ca 2+ stores. The Ca 2+ fluxes across the SR membrane, the leak, the influx mediated by the SR Ca 2+ -ATPases (SERCA), and the efflux through the IP 3 R channel are the fluxes already considered by the mathematical model of Haberichter et al [2].…”

Section: Mathematical Modelmentioning

confidence: 99%

“…The opening of the IP 3 R channels is triggered by IP 3 and Ca 2+ when they are bound to the respective binding sites of the channel, whereas Ca 2+ concentration in the vicinity of the channel controls the open-probability of the channel. As both Ca 2+ and IP 3 are required for opening the channel, this mechanism is named Ca 2+ -and-IP 3 -induced Ca 2+ release (CIICR) [2]. On the other hand, Ca 2+ can be released through the channels sensitive only to Ca 2+ itself; these channels are termed ryanodine receptor (RyR) channels and the corresponding transport mechanism is known as Ca 2+ -induced Ca 2+ release (CICR) [3].…”

Section: Introductionmentioning

confidence: 99%

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Mathematical Modelling of Ca2+ Oscillations in Airway Smooth Muscle Cells

et al. 2005

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Abstract. The action of different agonists such as acetylcholine on the membrane of airway smooth muscle cells may induce cytosolic Ca 2+ oscillations which can be a part of the Ca 2+ signalling pathway, eventually leading to cell contraction. The aim of the present study is to present a mathematical model of the possible effect of the initial Ca 2+ distribution within the cell on the form and frequency of induced Ca 2+ oscillations. It takes into account intracellular Ca 2+ stores such as sarcoplasmic reticulum and cytosolic proteins as well as Ca 2+ exchange across the plasma membrane. We are able to demonstrate a closer agreement of model predictions with observed Ca 2+ traces for a significantly wider range of parameter values, as was previously reported. We show also that the total cellular Ca 2+ content is an important system parameter especially because of the content in sarcoplasmic reticulum. At a total Ca 2+ increase of about 20%, the oscillation frequency increases by 25%; also, damped oscillations become sustained. Cases are indicated in which such a situation could occur.

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Section: Model Predictions and Discussionmentioning

confidence: 85%

Section: Model Predictions and Discussionmentioning

confidence: 96%

Section: Model Predictions and Discussionmentioning

confidence: 99%

Section: Mathematical Modelmentioning

confidence: 99%