The influence of donepezil and EGb 761 on the innate immunity of human leukocytes

Sochocka, Marta; Zaczyńska, Ewa; Taboł, Agnieszka; Czarny, Anna; Leszek, Jerzy; Sobczyński, Maciej

doi:10.1016/j.intimp.2010.08.024

Cited by 26 publications

(20 citation statements)

References 30 publications

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“…From these results, we can infer that donepezil is either able to directly stimulate α7 nAChR and not act as an inhibitor only or it has some other unknown pathway. Beside the anti-inflammatory pathway, donepezil was proven to be able to modulate viral progression and the modulation is probably based on a mechanism other than agonism of α7 nAChR [86,87]. This fact would support the results on the microglia cells.…”

Section: Inhibitors That Cross the Blood Brain Barriermentioning

confidence: 75%

Inhibitors of Acetylcholinesterase and Butyrylcholinesterase Meet Immunity

Pohanka

2014

IJMS

211

112

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Acetylcholinesterase (AChE) inhibitors are widely used for the symptomatic treatment of Alzheimer’s disease and other dementias. More recent use is for myasthenia gravis. Many of these inhibitors interact with the second known cholinesterase, butyrylcholinesterase (BChE). Further, evidence shows that acetylcholine plays a role in suppression of cytokine release through a “cholinergic anti-inflammatory pathway” which raises questions about the role of these inhibitors in the immune system. This review covers research and discussion of the role of the inhibitors in modulating the immune response using as examples the commonly available drugs, donepezil, galantamine, huperzine, neostigmine and pyridostigmine. Major attention is given to the cholinergic anti-inflammatory pathway, a well-described link between the central nervous system and terminal effector cells in the immune system.

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Section: Inhibitors That Cross the Blood Brain Barriermentioning

confidence: 75%

Inhibitors of Acetylcholinesterase and Butyrylcholinesterase Meet Immunity

Pohanka

2014

IJMS

211

112

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“…The effect was more noticeable than in the case of synthetic donepezil, which confirmed the effectiveness of the natural preparation [19]. Here we considered the possible influence of EGb 761 on cytokine production by human peripheral blood leukocytes (PBLs) ex vivo.…”

Section: Introductionmentioning

confidence: 56%

“…PBLs from healthy young volunteers, 20-40 years old (n=15, male 7, female 8) were isolated as previously described [19].…”

Section: Isolation Of Peripheral Blood Leukocytes (Pbls)mentioning

confidence: 99%

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Innate antiviral immunity of human PBLs and immunoregulatory activity of EGb 761

et al. 2014

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“…MMPs are also transcriptionally regulated by NF-jB, another important inflammation regulator. Notably, DP has been reported to inhibit NF-jB activation [18].…”

Section: Discussionmentioning

confidence: 99%