The influence of drugs on peripheral nerve regeneration

Bota, Olimpiu; Fodor, Lucian

doi:10.1080/03602532.2019.1632885

Cited by 30 publications

(16 citation statements)

References 132 publications

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“…Inflammation and the resulting edema directly or indirectly affect nerve damage and slow nerve recovery. The anti-inflammatory effects of steroids reduce nerve damage, promote nerve recovery, [ 8 , 9 ]. Moreover, steroids inhibit lipid peroxidation, stabilize nerve membranes, and promote axonal regeneration.…”

Section: Medicationsmentioning

confidence: 99%

Review of Drug Therapy for Peripheral Facial Nerve Regeneration That Can Be Used in Actual Clinical Practice

et al. 2022

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Although facial nerve palsy is not a life-threatening disease, facial asymmetry affects interpersonal relationships, causes psychological stress, and devastates human life. The treatment and rehabilitation of facial paralysis has many socio-economic costs. Therefore, in cases of facial paralysis, it is necessary to identify the cause and provide the best treatment. However, until now, complete recovery has been difficult regardless of the treatment used in cases of complete paralysis of unknown cause and cutting injury of the facial nerve due to disease or accident. Therefore, this article aims to contribute to the future treatment of facial paralysis by reviewing studies on drugs that aid in nerve regeneration after peripheral nerve damage.

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Section: Medicationsmentioning

confidence: 99%

Review of Drug Therapy for Peripheral Facial Nerve Regeneration That Can Be Used in Actual Clinical Practice

et al. 2022

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“…Currently, several pharmaceuticals have been approved by the FDA for PNI therapy through local injection or systemic administration, but effective results have not been achieved. Alternatively, drug-loaded NGCs can provide sustained release of a drug locally and reduce systemic side-effects; they typically stimulate nerve regeneration and myelination by acting on targets, activating signaling pathways, and promoting the growth and proliferation of the cells involved [ 115 ]. Melatonin can reduce oxidative stress and inhibit inflammation after nerve injury thus promoting the recovery of peripheral nerves [ 116 ].…”

Section: Live Cellsmentioning

confidence: 99%

3D printing of functional nerve guide conduits

Huang

Liu

et al. 2021

Burns &Amp; Trauma

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Nerve guide conduits (NGCs), as alternatives to nerve autografts and allografts, have been widely explored as an advanced tool for the treatment of peripheral nerve injury. However, the repairing efficiency of NGCs still needs significant improvements. Functional NGCs that provide a more favorable microenvironment for promoting axonal elongation and myelination are of great importance. In recent years, 3D printing technologies have been widely applied in the fabrication of customized and complex constructs, exhibiting great potential for tissue engineering applications, especially for the construction of functional NGCs. In this review, we introduce the 3D printing technologies for manufacturing functional NGCs, including inkjet printing, extrusion printing, stereolithography-based printing and indirect printing. Further, we summarize the current methods and strategies for constructing functional NGCs, such as designing special conduit architectures, using appropriate materials and co-printing with different biological cues. Finally, the challenges and prospects for construction of functional NGCs are also presented.

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“…[68] An extensive review by Bota et al on drugs tested in the context of recovery from peripheral nerve injury, concluded that an outstanding amount of substances have been suggested and tested, yet none is currently used to accelerate peripheral nerve regeneration, due to small sample sizes and a lack of clinical studies. [97]…”

Section: Pnsmentioning

confidence: 99%

Parallels between the Developing Vascular and Neural Systems: Signaling Pathways and Future Perspectives for Regenerative Medicine

2021

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Neurovascular disorders, which involve the vascular and nervous systems, are common. Research on such disorders usually focuses on either vascular or nervous components, without looking at how they interact. Adopting a neurovascular perspective is essential to improve current treatments. Therefore, comparing molecular processes known to be involved in both systems separately can provide insight into promising areas of future research. Since development and regeneration share many mechanisms, comparing signaling molecules involved in both the developing vascular and nervous systems and shedding light to those that they have in common can reveal processes, which have not yet been studied from a regenerative perspective, yet hold great potential. Hence, this review discusses and compares processes involved in the development of the vascular and nervous systems, in order to provide an overview of the molecular mechanisms, which are most promising with regards to treatment for neurovascular disorders. Vascular endothelial growth factor, semaphorins, and ephrins are found to hold the most potential, while fibroblast growth factor, bone morphogenic protein, slits, and sonic hedgehog are shown to participate in both the developing vascular and nervous systems, yet have not been studied at the neurovascular level, therefore being of special interest for future research.

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The influence of drugs on peripheral nerve regeneration

Cited by 30 publications

References 132 publications

Review of Drug Therapy for Peripheral Facial Nerve Regeneration That Can Be Used in Actual Clinical Practice

Review of Drug Therapy for Peripheral Facial Nerve Regeneration That Can Be Used in Actual Clinical Practice

3D printing of functional nerve guide conduits

Parallels between the Developing Vascular and Neural Systems: Signaling Pathways and Future Perspectives for Regenerative Medicine

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