The influence of drugs that change blood pressure on intraocular pressure in the anaesthetized rat

Schulz, Werner; Zwieten, P. A. van

doi:10.1007/bf00440670

Cited by 12 publications

(3 citation statements)

References 18 publications

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“…Acute increases in arterial pressure in response to infravenous infusion of epinephrine or vasopressin elevate, rather than reduce, IOP. 8 We could find only one other study of IOP in chronic experimental hypertension. Funk et al 9 reported that IOP is decreased in strokeprone spontaneously hypertensive rats compared with that in normotensive Wistar-Kyoto controls and found a negative correlation between IOP and blood pressure in hypertensive rats.…”

Section: Discussionmentioning

confidence: 99%

Decreased intraocular pressure in dogs with one-kidney, one wrapped hypertension.

Bell¹,

Hollingsworth²,

Overbeck³

1987

Hypertension

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SUMMARY We examined the relationship of intraocular pressure and the development of onekidney, one wrapped (perinephritic) hypertension in the dog. Conscious femoral arterial pressure (direct arterial puncture) and intraocular pressure (Schiotz tonometer) were measured weekly before and after the surgical induction of hypertension in 11 healthy male mongrel dogs and before and after unilateral nephrectomy in 15 normotensive control dogs. Preoperative mean arterial pressure (102 ± 5 vs 99 ± 8 [SD] mm Hg, hypertensive vs control dogs) and intraocular pressure (18.1 ± 2.5 ys 17.7 ±2.1 mm Hg, hypertensive vs control dogs) were similar in both groups. In normotensive control dogs, mean arterial pressure and intraocular pressure averaged over the postoperative period (4-8 weeks) did not differ significantly from preoperative values. In contrast, during the same period arterial pressure significantly increased and intraocular pressure significantly decreased in hypertensive dogs (arterial pressure, 163 ± 8 mm Hg; intraocular pressure, 11.9 ± 4.0 mm Hg; p < 0.001 for both values compared with corresponding values in control dogs). Intraocular pressure was inversely related to arterial pressure in hypertensive dogs (r = 0.56, p<0.01). These observations indicate that intraocular pressure decreases with the development of canine one-kidney, one wrapped hypertension. The mechanism of this decrease may be related to abnormalities in Na+,K + -adenosine triphosphatase activity found in this form of hypertension. (Hypertension 10: 152-156, 1987) KEY WORDS * blood pressure • aqueous humor • Na+,K+-adenosine triphosphatase T HERE is evidence for a circulating inhibitor of the Na + ,K + pump in dogs with chronic onekidney, one wrapped (1K1W; perinephritic) hypertension.1 -2 Because inhibition of Na + ,K + -adenosine triphosphatase (Na + ,K + -ATPase) has been associated with decreases in intraocular pressure, 34 we measured intraocular pressure during the development of perinephritic hypertension in dogs. Materials and MethodsOur techniques were similar to those we have used previously.15 Briefly, we trained healthy male mongrel pound dogs weighing between 20 and 32 kg and maintained on standard dog chow and water ad libitum

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Section: Discussionmentioning

confidence: 99%

Decreased intraocular pressure in dogs with one-kidney, one wrapped hypertension.

Bell¹,

Hollingsworth²,

Overbeck³

1987

Hypertension

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“…However, the anatomy of the rabbit aqueous outflow system is very different from that of the primate; and availability of the monkey in sizable numbers for research is impractical. Until recently the rat has itself been impractical as a subject for IOP research because of limitations of measuring methods (Ohnesorge et al 1968;Schulz & van Zwieten 1971;Funk et al 1985). The Tono-Pen, a tonometer widely used clinically, has been evaluated for use in the rat (Moore et al 1993;Mermoud et al 1994) and this instrument (Mermoud et al 1994;Moore et al 1995a) and also a pneumotonometer (Shareef et al 1995) have been used to make noninvasive IOP measurements in anesthetized rats.…”

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confidence: 99%

Intraocular pressure measurement in the conscious rat

Cabrera

Wagner²,

Schork³

et al. 1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose. To develop a method for measurement of intraocular pressure in conscious, unsedated rats. Methods. The animal was gently held with a thick fabric mitten, topical anesthetic drops were instilled and the Tono-Pen was applied to the cornea. Result. Measurements in a total of 51 animals did not differ significantly among four strains studied: the overall mean intraocular pressure∫standard deviation was 13.0∫1.2 mm Hg. Several intraocular pressure tolerance limits were calculated from this conscious rat data to provide a baseline estimate for future studies.Conclusions. This measurement method in conscious rats may contribute to making this widely used laboratory animal available for intraocular pressure research.Key words: glaucoma -intraocular pressure -rat -tonometry -Tono-Pen. Acta Ophthalmol. Scand. 1999: 77: 33-36 Copyright c Acta Ophthalmol Scand 1999. ISSN 1395-3907 A nimal models of intraocular pressure (IOP) research have been essentially limited to the rabbit and monkey. However, the anatomy of the rabbit aqueous outflow system is very different from that of the primate; and availability of the monkey in sizable numbers for research is impractical. Until recently the rat has itself been impractical as a subject for IOP research because of limitations of measuring methods (Ohnesorge et al. 1968;Schulz & van Zwieten 1971;Funk et al. 1985). The Tono-Pen, a tonometer widely used clinically, has been evaluated for use in the rat (Moore et al. 1993;Mermoud et al. 1994) and this instrument (Mermoud et al. 1994;Moore et al. 1995a) and also a pneumotonometer (Shareef et al. 1995) have been used to make noninvasive IOP measurements in anesthetized rats. The present study examines IOP in the conscious, unsedated rat, measured with the Tono-Pen, an approach first mentioned by Moore et al. (1995b) and then outlined by them (1996). MaterialsAll experiments were performed using the Tono-Pen XL (TP) (Mentor Ophthalmics, Inc., Norwell, MA., U.S.A.).Experiments were performed on four rat strains: Sixteen male Sprague-Dawley (Harlan Sprague Dawley, Indianapolis, IN), weight 180-220 grams, 8-12 weeks old; University of Michigan colonies were the sources of the other three strains: two subgroups of male outbred Long Evans hooded, eight in one and ten in the other, weight 300-350 grams, 10 months old; twelve female genetically hypertensive, stroke prone (SHRSP), weight 200-250 grams, 7 months old; five male normotensive Wistar Kyoto (WKY), weight 250-300 grams, 8 months old. All experiments were performed in compliance with the Declaration of Helsinki. MethodsPrevious studies which calibrated the TP in anesthetized rats (Moore et al. 1993;Mermoud et al. 1994) described the problems of applying this instrument, which was designed for the human eye, to the rat. Therefore, we began developing our measuring method in anesthetized animals, and incidentally obtained data on the behavior of this instrument in our hands. We used a method previously described (Mermoud et al. 1994) in each of our four rat strains...

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“…The aforementioned concept of the relationship between IOP and arterial or venous blood pressure has mainly been obtained from studies on anesthetized rabbits (see Schulz & Van Zwieten, 1971 ;Schmiedeberg, Thiel & Van Zwieten, 1971 + quoted literature; for a review see Leydhecker, 1973).…”

Section: The Relationship Between Iop and Blood Pressurementioning

confidence: 99%

Background of the drug treatment of glaucoma

Zwieten¹

1977

Doc Ophthalmol

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The influence of drugs that change blood pressure on intraocular pressure in the anaesthetized rat

Cited by 12 publications

References 18 publications

Decreased intraocular pressure in dogs with one-kidney, one wrapped hypertension.

Decreased intraocular pressure in dogs with one-kidney, one wrapped hypertension.

Intraocular pressure measurement in the conscious rat

Background of the drug treatment of glaucoma

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