The influence of early life sexual abuse on oxytocin concentrations and premenstrual symptomatology in women with a menstrually related mood disorder

Crowley, Shannon K.; Pedersen, Cort A.; Leserman, Jane; Girdler, Susan S.

doi:10.1016/j.biopsycho.2015.04.003

Cited by 13 publications

(8 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One prior cross-sectional study has examined how early life sexual abuse in the context of PMDD (or subthreshold PMDD) moderates the association between a single premenstrual OXT measurement (via plasma) and average premenstrual symptom severity ( 40 ). The authors found that, among women with early life sexual abuse, these “tonic” premenstrual OXT levels were higher than those without early sexual abuse.…”

Section: Discussionmentioning

confidence: 99%

Early Life Abuse Moderates the Effects of Intranasal Oxytocin on Symptoms of Premenstrual Dysphoric Disorder: Preliminary Evidence From a Placebo-Controlled Trial

et al. 2018

Self Cite

View full text Add to dashboard Cite

Background: Although intranasal oxytocin (OXT) has been proposed to be a promising treatment for some psychiatric disorders, little research has addressed individual difference factors that may predict response to OXT. One such factor is early life abuse (ELA), which has widespread influences on social-emotional processing and behavior. This single-blind, placebo-controlled crossover trial examined the role of ELA in shaping the effects of intranasal OXT (vs. placebo) on daily behavioral symptoms in women with three or more prospectively-diagnosed cycling symptoms of premenstrual dysphoric disorder (PMDD).Methods: Participants were ten women with PMDD (n = 8) or subthreshold PMDD (n = 2), who had experienced ELA prior to age 13 (n = 5) or no ELA (n = 5). They completed two study visits during the late luteal (premenstrual) phase: once following administration of intranasal OXT and once following intranasal placebo (counterbalanced). Participants then self-administered OXT or placebo at home three times per day for 5 days or until menstrual onset, and prospectively rated daily emotional symptoms of PMDD. Power was adequate to detect medium main and interactive effects.Results: Among women with ELA, intranasal OXT (vs. placebo) increased the premenstrual emotional symptoms of PMDD, whereas among women without ELA, OXT decreased symptoms.Conclusion: This study adds to a growing literature highlighting the importance of considering historical social contexts and traits (such as ELA) as moderators of therapeutic response to OXT.

show abstract

Section: Discussionmentioning

confidence: 99%

Early Life Abuse Moderates the Effects of Intranasal Oxytocin on Symptoms of Premenstrual Dysphoric Disorder: Preliminary Evidence From a Placebo-Controlled Trial

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Articles that did not meet the criteria of case-control studies with physical and/or sexual violence in adolescence and/or childhood as an independent variable were discarded. Therefore, the following were excluded: Bunevicius et al (2013), Crowley et al (2015), Girdler et al (1998) and Girdler et al (2004); Soyda Akyol, Karakaya Arısoy, and Çayköylü (2013), Wittchen, Perkonigg, and Pfister (2003). As well, were excluded cross-sectional studies (Golding et al, 2000;Koci & Strickland, 2007;Kovac, Klapow, Kroenke, Spitzer, & Williams, 2003;Segebladh et al, 2011), and narrative reviews (Ross & Steiner, 2003).…”

Section: Methodsmentioning

confidence: 99%

“…It is important to mention that search for "menstrually-related mood disorders" was explored directly in the PubMed searching box as a MeSH term and did not show results. However the term was used to encompass both premenstrual syndrome (PMS) and premenstrual dysphoric disroder (PMDD) (Bunevicius et al, 2012;Crowley et al, 2015). The present work was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA) (Liberati et al, 2009).…”

Section: Design Of the Studymentioning

confidence: 99%

“…It is estimates that roughly 75% of women in reproductive age report physical premenstrual changes, and an additional percentage is affected by menstrually-related mood disorders (MRMDs), a term that has been used to encompass both premenstrual syndrome (PMS) and premenstrual dysphoric disroder (PMDD) (Bunevicius, Leserman, & Girdler, 2012;Crowley, Pedersen, Leserman, & Girdler, 2015). PMS affects approximately 20% to 50% of women (APA, 2000;Pearlstein & Steiner, 2012), and a smaller percentage (3% to 8%) meets criteria for PMDD (Yonkers, O'Brien, & Eriksson, 2008), the severe form of PMS.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of physical and sexual violence during childhood and/or adolescence on the development of menstrual related mood disorders: A systematic review and meta-analysis

et al. 2021

View full text Add to dashboard Cite

Background. Abuse in early life stages has been proposed as an etiological risk factor for developing menstrually-related mood disorders (MRMDs). Objetive. To evaluate whether there is a relation between the occurrence of physical and/or sexual violence in childhood and/or adolescence and the development of MRMDs in adulthood. Method. A systematic search was conducted in PubMed, Web of Science, and ScienceDirect, with the route (“Premenstrual Syndrome”[Mesh]) OR (“Premenstrual Dysphoric Disorder”[MeSH]) AND (“Violence”[Mesh]) / (“menstrually-related mood disorders” AND “abuse”). Fifty-four articles were initially reviewed and 32 were excluded based on the criteria. Twenty-two articles were thoroughly reviewed. Finally, five articles (publication years 2014, 2013, 2012, 2007, and 2003) were included in the systematic review and submitted to a meta-analysis. Results. Results indicate that having been exposed to physical and/or sexual violence in childhood and/or adolescence increases 1.99 times the risk of experiencing MRMDs in adulthood in comparison with women who did not experience that type of violence (odds ratio [OR] = 1.99; 95% confidence interval [1.58, 2.51]). Discussion and conclusion. The present work provides evidence that a woman who experienced violence through physical and/or sexual abuse during childhood and/or adolescence has a greater risk of developing MRMDs in adulthood.

show abstract

“…A number of studies show that OT is closely related to affiliative relationships, being a neuropeptide that “acts to enhance the perceptual salience of social and emotional stimuli in general.” 88,89 However, whether OT has effects (or associations) is not always straightforward, varying as a function of the context in which their effects (or associations) are assessed as well as the person’s gender, maternal status, personality, attachment style, general stress reactivity, and early life experiences to name a few. 88,90 –93 Given the importance of these variables, our analysis of the role of any of the hormones, neuropeptides, or neurotransmitters in human mothering needs to keep in mind the potential role of other factors that could influence whether or not these brain chemicals have effects on maternal behavior and affect. In prospective mothers, OT levels in the first trimester predict postpartum characteristics of the expression of maternal behavior and coordination with infant state.…”

Section: Levels Of Analysismentioning

confidence: 99%

Molecular and Genetic Bases of Mammalian Maternal Behavior

Fleming

Kraemer

2019

Gender and the Genome

View full text Add to dashboard Cite

New mammalian mothers undergo an increase in their maternal responsiveness with the birth of their infants. Associated with changes in responsiveness are how attracted mothers are to infant cues, mothers' affective state, and their cognitive and executive function. In comparison to nonmothers, new mothers are more attracted to infant odors and are more easily alerted to their vocalizations; they undergo a reduction in withdrawal behaviors and anxiety, but increased lability. Their maternal sensitivity (human or licking intensity, rat) is associated with higher levels of attention and working memory. Maternal responsiveness and these associated behaviors are associated with large shifts in maternal hormones across parturition. Changes in expression of neuropeptides and neurotransmitters are affected by mothers' prior experiences, including their very early experiences in their families of origin. The present review describes the regulation of mothering and associated behaviors by the neurotransmitters, oxytocin, dopamine, and serotonin, in a rat model and in humans. Emphasis is then given to studies that focus on the role of genes and what we know about their expression in the functioning of these 3 neurochemical systems in new mothers. Studies of early experience, genetics, and human mothering show gene-by-environment interplays (interactions) for a number of DNA singlenucleotide polymorphism within both the oxytocin and serotonin systems, where associations between mothers' early experiences and mothering/affect depend on mothers' genotype. Studies also show associations between different dopamine genes and many aspects of both mothering and maternal affect. Where known, we also discuss evidence that the relation between early experience and mothering is often an indirect one, mediated through an effect of experience on mothers' affect or executive function. In many cases, mothers' genetic profile moderates these relations. Finally, preliminary evidence suggests a role of epigenetic mechanisms in these processes.

show abstract

The influence of early life sexual abuse on oxytocin concentrations and premenstrual symptomatology in women with a menstrually related mood disorder

Cited by 13 publications

References 98 publications

Early Life Abuse Moderates the Effects of Intranasal Oxytocin on Symptoms of Premenstrual Dysphoric Disorder: Preliminary Evidence From a Placebo-Controlled Trial

Early Life Abuse Moderates the Effects of Intranasal Oxytocin on Symptoms of Premenstrual Dysphoric Disorder: Preliminary Evidence From a Placebo-Controlled Trial

Effect of physical and sexual violence during childhood and/or adolescence on the development of menstrual related mood disorders: A systematic review and meta-analysis

Molecular and Genetic Bases of Mammalian Maternal Behavior

Contact Info

Product

Resources

About