The influence of ecological factors in the modulation of pollution biomarkers of two small pelagic marine fish

Nos, David; Navarro, Joan; Solé, Montserrat

doi:10.1016/j.marpolbul.2023.114717

Cited by 2 publications

(3 citation statements)

References 76 publications

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“…In contrast with the findings of Fukami et al, 64 who reported that the antihyperlipidemic clofibric acid (200 μM) produced slight and moderate inhibitions on CbE1 and CbE2 of human liver microsomes, the present work did not reveal any effect on this enzymatic activity in the liver of tench after in vitro exposure to 100 μM. In vitro exposures of microsomal fractions of the liver with other lipid regulators such as fenofibrate and simvastatin (100 μM) evidenced weak inhibitions on CbE activity in B. meridionalis , Squalius laietanus , S. solea , Scyliorhinus canicular , Engraulis encrasicolus , and S. pilchardus 4–6,65 and moderate inhibitions of this enzymatic activity in D. labrax , Trachyrhynchus scabrus , A. rostratus , Cataetix laticeps , and S. aurata 6,7 as also Ribalta et al 66 observed in humans. Solé et al 60 also documented slight inhibitions (<10% vs. control) on plasma CbE of dolphins after in vitro exposure to these compounds.…”

Section: Resultscontrasting

confidence: 99%

“…On the contrary, Solé et al 73 indicated that hepatic CbE activity was negatively correlated with the size of S. senegalensis . More recently, Soto‐Mancera et al, 7 and Nos et al 65,74 observed the same trend in S. aurata , Auxis rochei, Thunnus alalunga, E. encrasicolus , and S. pilchardus . Concerning HSI, and in the line of this work result, Soto‐Mancera et al 7 found no correlation between hepatic CbE activity and this index in S. aurata .…”

Section: Resultsmentioning

confidence: 66%

“…Engraulis encrasicolus, and S. pilchardus[4][5][6]65 and moderate inhibitions of this enzymatic activity in D. labrax, Trachyrhynchus scabrus, A. rostratus, Cataetix laticeps, and S. aurata 6,7 as also Ribalta et al66 observed in humans. Solé et al60 also documented slight inhibitions (<10% vs. control) on plasma CbE of dolphins after in vitro exposure to these compounds.…”

mentioning

confidence: 58%

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Sensitivity of cholinesterases and carboxylesterases to pharmaceutical products in Tinca tinca

Oropesa,

González‐Sánchez,

Beltrán

2024

Environmental Toxicology

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Discharges to the aquatic environment of pharmaceuticals represent a hazard to the aquatic organisms. Subchronic assay with 17‐alpha‐ethinylestradiol (EE2) and in vitro essays with pharmaceuticals of environmental concern were conducted to examine the sensitivity of tissue acetylcholinesterase (AChE) and carboxylesterase (CbE) activities of Tinca tinca to them. Subchronic exposure to 17‐alpha‐EE2 caused significant effects on brain, liver, and muscle CbE, but no on AChE activities. Most of the pharmaceuticals tested in vitro were considered as weak inhibitors of tissular AChE activity. Depending on the tissues, some compounds were classified as moderate inhibitors of CbE activity while other were categorized as weak enzymatic inhibitors. An opposite trend was observed depending on the tissue, while brain and liver CbE activities were inhibited, the muscle CbE activity was induced. Changes experienced on enzymatic activities after exposure to pharmaceuticals might affect the physiological functions in which these enzymes are involved. In vitro exposure to 17‐alpha‐EE2 in tench could be an informative, but not a surrogate model to know the effect of this synthetic estrogen on AChE and CbE activities.

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Section: Resultscontrasting

confidence: 99%

Section: Resultsmentioning

confidence: 66%

mentioning

confidence: 58%

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Sensitivity of cholinesterases and carboxylesterases to pharmaceutical products in Tinca tinca

Oropesa,

González‐Sánchez,

Beltrán

2024

Environmental Toxicology

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B-esterases activities in several tissues of the marine fish: sea bass and hake, as potential biomarkers of bisphenol A derivatives

Solé,

Omedes,

Brandts

et al. 2024

J Environ Expo Assess

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In the marine environment, a new threat linked to plastic pollution relates to plastic additives. This threat encompasses multiple chemical compound groups with a high bioaccumulation potential for these chemical mixtures. Hence, informative biomarkers are needed to indicate the effects of environmentally realistic mixtures of these additives. This study proposes an in vitro approach using tissue homogenates of two marine fish, the European sea bass and hake, which are both of interest in aquaculture and fisheries. The selected biomarkers are B-esterase activities comprising acetylcholinesterase (AChE) and carboxylesterases (CEs). The physiological role of AChE in brain and muscle is mainly neural transmission, while CEs participate in liver detoxification processes. However, B-esterases are also widely distributed in other tissues/organs, where their role is yet to be determined, but their inhibition may have undesired biological consequences. Here, we compared the interaction of the plastic additives, bisphenol A and some of its derivatives, like tetrabromobisphenol A (TBBPA), with B-esterase activities. We particularly focused not only on the robust and broadly distributed CE enzymes in brain, gonad, liver, kidney, and plasma tissues of two marine fish, but also on the use of two commercial substrates, p-nitrophenyl butyrate and α-naphthyl butyrate, tentatively representing two CE isoforms. The results evidenced specific species and tissue responses that could be due to a diverse isoform composition. They identified sea bass as better protected against neurotoxic exposures, at least in terms of B-esterase composition. The flame retardant TBBPA was the most reactive to B-esterases inhibition, although Bisphenol A bis (2,3-dihydroxy propyl) ether and Bisphenol F bis (3-chloro-2-hydroxypropyl) ether warrant further toxicology assessments.

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The influence of ecological factors in the modulation of pollution biomarkers of two small pelagic marine fish

Cited by 2 publications

References 76 publications

Sensitivity of cholinesterases and carboxylesterases to pharmaceutical products in Tinca tinca

Sensitivity of cholinesterases and carboxylesterases to pharmaceutical products in Tinca tinca

B-esterases activities in several tissues of the marine fish: sea bass and hake, as potential biomarkers of bisphenol A derivatives

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