The influence of enhanced postoperative inflammation by the intrapleural administration of streptococcal preparation (OK-432) on the prognosis of completely resected non-small-cell lung cancer

Abstract

Based on the above findings, postoperative prolonged inflammation does not seem to affect the progression of subclinically residual tumor cells.

No compensatory lung growth after resection in a one-year follow-up cohort of patients with lung cancer

“…Three months after surgery m L changes were minimally detected because of the acute remodeling processes and the effects of post-surgical therapies. Inflammation, which increases m L and blood flow, can persist only a few months after lung resection (19,20). In the present cohort, the m L of the non-operated lung did not change significantly at M3, but individual values were scattered, suggesting that some patients exhibit a transient increase in their m L that is subsequently lost, as demonstrated by the negative correlation between the changes in m L between M3 and M12 and mass at M3.…”

A Unique Method for Repairing Intraoperative Pulmonary Air Leakage with Both Polyglycolic Acid Sheets and Fibrin Glue

“…Although various postoperative management strategies for pulmonary air leakage have been applied, including a water-sealing technique of pleural drainage [3][4][5], intraoperative repair of pulmonary fistulas from dissected lung parenchyma or suture lines on the lung is considered essential for prevention of postoperative persistent air leakage [6][7][8][9][10]. To protect against prolonged air leakage after a pulmonary resection, an intrapleural injection of OK-432, a lyophilized preparation of the heat-and penicillin-treated Su strain of the Streptococcus pyogenes group A3 bacterium, is often performed for pleurodesis in Japan; however, this has several disadvantages due to the inflammatory reaction [11]. Recently, the advent of both fibrin glue and polyglycolic acid (PGA) sheets has improved the repair of pulmonary air leakage [9,10,12].…”