The influence of environmental contaminants on lysosomal activity in the digestive cells of mussels (Mytilus galloprovincialis) from the Venice Lagoon

Lowe, David M.; Fossato, V.U.

doi:10.1016/s0166-445x(99)00054-5

Cited by 58 publications

(25 citation statements)

References 27 publications

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“…Acetylcholinesterase activity is involved in the deactivation of acetylcholine at nerve endings, preventing continuous nerve firings, which are vital for normal functioning of sensory and neuromuscular systems. Lysosomes accumulate a diverse range of chemical contaminants that can lead to membrane damage, resulting in leakage of their contents into the cytosol and subsequent damage to cells [19]. This paper presents the results of a two-year monitoring study involving chemical analysis and biomarker measurements.…”

Section: Introductionmentioning

confidence: 99%

A pollution-monitoring pilot study involving contaminant and biomarker measurements in the Seine Estuary, France, using zebra mussels (Dreissena polymorpha)

Minier

Abarnou

Jaouen-Madoulet

et al. 2006

Environmental Toxicology and Chemistry

100

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Abstract-Zebra mussel (Dreissena polymorpha) is an invasive species that has proliferated in European and North American rivers and lakes during the last century. In this study, D. polymorpha has been used to provide information on contamination levels and biological effects in the Seine Estuary (France). The bivalves accumulated polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs) to a high degree with values reaching 800 ng/g dry weight for PCBs (sum of 20 congeners), and 1,000 ng/g dry weight of PAHs (sum of 14 compounds) in the whole body. These values are among the highest reported of PCBs and, to a lesser extent, of PAHs in other contaminated areas in the world. Toxic equivalent quantities of PCBs and PAHs detected in zebra mussels varied from 20 to 40 pg dioxin equivalents/g dry weight for PCBs and up to 120 ng benzo[a]pyrene equivalents/ g dry weight for PAHs, indicating a high potential risk for animals feeding on them. Biological impacts, such as altered condition index, decreased lysosomal stability, and high levels of multixenobiotic resistance (MXR) proteins also were detected in mussels living downstream of Rouen, the main city of the Seine Estuary. Taken together, these results indicate that the Seine Estuary is a heavily polluted area with the potential to cause deleterious health effects in some endogenous living organisms. This study also shows that chemical and biological measurements bring different but complementary results that can help diagnose environmental health.

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Section: Introductionmentioning

confidence: 99%

A pollution-monitoring pilot study involving contaminant and biomarker measurements in the Seine Estuary, France, using zebra mussels (Dreissena polymorpha)

Minier

Abarnou

Jaouen-Madoulet

et al. 2006

Environmental Toxicology and Chemistry

100

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“…They can give an insight of the potential effect of contaminants in organisms in the natural environment. In order to assess the impact of persistent pollutants on the marine ecosystem a suite of biomarkers are being extensively used worldwide (Ozretic & Krajnovic-Ozretic, 1992;Lowe & Fossato, 2000). These biomarkers are being used to evaluate exposure of various species of sentinel marine organisms (e.g.…”

Section: Discussionmentioning

confidence: 99%

Effects of Pesticides on Marine Bivalves: What Do We Know and What Do We Need to Know?

Renault¹

2011

Pesticides in the Modern World - Risks and Benefits

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“…Among invertebrates, benzo[a]pyrene is a common contaminant that induces alteration in the MN profile of hemocytes [36]. The use of hemocytes provides many advantages: (i) these cells form part of the open circulation and are therefore likely to be homogeneously exposed to contaminants; (ii) laboratory studies have suggested that these cells are sensitive to reference genotoxicants; (iii) the cells can be procured irrespective of the reproductive phase of the animals; (iv) the assay may be complemented by other cytotoxicity tests (e. g., neutral red retention assay) [40]; (v) the assay is applicable to both laboratory and field conditions.…”

Section: Discussionmentioning

confidence: 99%

Nuclear Morphology and Lysosomal Stability of Molluskan Hemocytes as Possible Biomarkers of Arsenic Toxicity

Chakraborty¹,

Ray²

2009

CLEAN Soil Air Water

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The frequency of nuclear aberrations and neutral red retention time of hemocytes in the mollusk Lamellidens marginalis were recorded under exposure to sublethal concentrations of sodium arsenite in order to examine the sensitivity and effectiveness of these inexpensive assays for screening the toxicity of As 3+ in a freshwater ecosystem. A dose and time dependent increase in the density of micronucleated and binucleated hemocytes and gill cells was indicative of the pronounced genotoxic effect of arsenic on this animal. The disruption of intrahemocyte homeostasis imposed by this natural toxicant was evident from a dose and time dependent reduction in the lysosomal stability of the hemocytes of the animal. The tested parameters are indicative of arsenic toxicity in L. marginalis in the freshwater systems of the arsenic affected geographical areas of West Bengal, India.

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The influence of environmental contaminants on lysosomal activity in the digestive cells of mussels (Mytilus galloprovincialis) from the Venice Lagoon

Cited by 58 publications

References 27 publications

A pollution-monitoring pilot study involving contaminant and biomarker measurements in the Seine Estuary, France, using zebra mussels (Dreissena polymorpha)

A pollution-monitoring pilot study involving contaminant and biomarker measurements in the Seine Estuary, France, using zebra mussels (Dreissena polymorpha)

Effects of Pesticides on Marine Bivalves: What Do We Know and What Do We Need to Know?

Nuclear Morphology and Lysosomal Stability of Molluskan Hemocytes as Possible Biomarkers of Arsenic Toxicity

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