The Influence of Environmental Contaminants and Lifestyle on Testicular Damage and Male Fertility

Selvaraju, Sellappan; Jodar, Meritxell; Krawetz, Stephen A.

doi:10.1007/7653_2014_13

Cited by 5 publications

(2 citation statements)

References 146 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Potential regulatory roles during fertilization and embryogenesis have been suggested for the collection of ncRNAs including confrontation and consolidation of the maternal and paternal genome during fertilization (reviewed in Bourc'his and Voinnet 2010; Krawetz et al 2011;Jodar et al 2013). Several recent studies have suggested that environmental changes may be transmitted to the offspring through spermatozoa, influencing their fertility or health (reviewed in Ng et al 2010;Rando 2012;Linschooten et al 2013;Selvaraju et al 2014). These include a predisposition to diabetes or perhaps even depression in the offspring which can reflect diet or a previous response of the father to traumatic stress (Carone et al 2010;Ng et al 2010;Rando 2012;Gapp et al 2014).…”

Section: Spermatozoal Retained Rnasmentioning

confidence: 99%

The protein and transcript profiles of human semen

2015

Self Cite

View full text Add to dashboard Cite

The increasing use of "-omics" (genomic, transcriptomic, proteomic, epigenomic, and metabolomic) high-throughput measurement technologies over the past decade is beginning to reveal the complexity of human biology and physiology through the interactions of DNA, RNA, related proteins and small molecules. In reproductive medicine, the majority of this work, has thus far focused on the female factors, e.g., the oocyte, since they provide both the environment and the majority of elements required for embryogenesis. State-of-the-art sequencing and computational analyses have enabled a deeper understanding of the underlying components. Contrary to being simply a silent delivery vehicle to the oocyte of the packaged male DNA, sperm provide both a specific epigenetically marked genome together with a complex population of RNAs and proteins that are crucial for early embryogenesis. In addition to the sperm, seminal fluid appears to serve multiple roles providing a supplementary series of components that allow the sperm to successfully reach and fertilize the oocyte and prepare the female immune system to tolerate the semiallosteric embryo. A global analysis and review of what is presently known regarding the unique role of each component of the male factor and their associated interactions begins to shed light on this emergent field.

show abstract

Section: Spermatozoal Retained Rnasmentioning

confidence: 99%

The protein and transcript profiles of human semen

2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…Epidemiological and animal model studies have revealed that most environmental contaminants such as heavy metals, phthalates, fungicides, and pesticides can alter the immune privilege state of the testis (Estill & Krawetz, ; Selvaraju, Jodar, & Krawetz, ). Studies in mice have shown that high dose (3 mg/kg) cadmium chloride and arsenic (200 ppm) might disrupt spermatogenesis by damaging testicular architecture (Elkin, Piner, & Sharpe, ; Guvvala et al, ).…”

Section: Factors Affecting the Immune Regulatory Mechanism Of The Repmentioning

confidence: 99%

Immune regulatory molecules as modifiers of semen and fertility: A review

Archana

Selvaraju

Binsila

et al. 2019

Molecular Reproduction Devel

Self Cite

View full text Add to dashboard Cite

Declining fertility rates in both human and animals is a cause for concern. While many of the infertility cases are due to known causes, idiopathic infertility is reported in 30% of the infertile couples. In such cases, 18% of the infertile males carry antisperm antibodies (ASAs). Such data are lacking in livestock, wherein 20–30% of the animals are being culled due to low fertility. In males, the blood–testis barrier (BTB) and biomolecules in the semen provide an immuno‐tolerant microenvironment for spermatozoa as they traverse the immunologic milieu of both the male and female reproductive tracts. For example, insults from environmental contaminants, infections and inflammatory conditions are likely to impact the immune privilege state of the testis and fertility. The female mucosal immune system can recognize allogenic spermatozoa‐specific proteins affecting sperm kinematics and sperm‐zona binding leading to immune infertility. Elucidating the functions and pathways of the immune regulatory molecules associated with fertilization are prerequisites for understanding their impact on fertility. An insight into biomolecules associated with spermatozoal immune tolerance may generate inputs to develop diagnostic tools and modulate fertility. High‐throughput sequencing technologies coupled with bioinformatics analyses provides a path forward to define the array of molecules influencing pregnancy outcome. This review discusses the seminal immune regulatory molecules from their origin in the testis until they traverse the uterine environment enabling fertilization and embryonic development. Well‐designed experiments and the identification of biomarkers may provide a pathway to understand the finer details of reproductive immunology that will afford personalized therapies.

show abstract

Metal in water: an assessment of toxicity with its biogeochemistry

Mondal¹,

Bordoloi²

2023

Metals in Water

View full text Add to dashboard Cite

The Influence of Environmental Contaminants and Lifestyle on Testicular Damage and Male Fertility

Cited by 5 publications

References 146 publications

The protein and transcript profiles of human semen

The protein and transcript profiles of human semen

Immune regulatory molecules as modifiers of semen and fertility: A review

Metal in water: an assessment of toxicity with its biogeochemistry

Contact Info

Product

Resources

About