The influence of excipients on physical and pharmaceutical properties of oral lyophilisates containing a pregabalin-acetaminophen combination

Chiriac, Aurica P.; Diaconu, Alina; Niţă, Loredana E.; Tudorachi, Niță; Mititelu-Tarțău, Liliana; Crețeanu, Andreea; Dragostin, Oana Maria; Rusu, Daniela; Popa, Grațiela

doi:10.1080/17425247.2017.1291629

Cited by 8 publications

(3 citation statements)

References 49 publications

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“…The first step was to include CAM membrane fragments taken in paraffin. The obtained paraffin blocks were cut into the microtome at 2-3 µm thick, and furthermore the sections were specifically stained with haematoxylin and eosin H & E [29]. The microscopic examination was performed using a Nikon Eclipse 50i microscope.…”

Section: In Vivo Evaluation Of Angiogenic Activity Using a Cam Modelmentioning

confidence: 99%

Designing of Chitosan Derivatives Nanoparticles with Antiangiogenic Effect for Cancer Therapy

et al. 2020

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Angiogenesis is a physiological process involving the growth of new blood vessels, which provides oxygen and required nutrients for the development of various pathological conditions. In a tumor microenvironment, this process upregulates the growth and proliferation of tumor cells, thus any stage of angiogenesis can be a potential target for cancer therapies. In the present study, chitosan and his derivatives have been used to design novel polymer-based nanoparticles. The therapeutic potential of these newly designed nanoparticles has been evaluated. The antioxidant and MTT assays were performed to know the antioxidant properties and their biocompatibility. The in vivo antiangiogenic properties of the nanoparticles were evaluated by using a chick Chorioallantoic Membrane (CAM) model. The obtained results demonstrate that chitosan derivatives-based nanostructures strongly enhance the therapeutic effect compared to chitosan alone, which also correlates with antitumor activity, demonstrated by the in vitro MTT assay on human epithelial cervical Hep-2 tumor cells. This study opens up new direction for the use of the chitosan derivatives-based nanoparticles for designing of antiangiogenic nanostructured materials, for future cancer therapy.While stimulation of angiogenesis in cancer leads to metastasis, the anti-angiogenic therapy proved to be an important approach against tumor growth. In this respect, it is a well-known fact that the consumption of antioxidants can be recommended to achieve the inhibition of angiogenesis or reversal of unwanted cell-cell adherence [1]. Several studies have been conducted to investigate the connection between antioxidants and pathological angiogenesis, thus leading to mixed conclusions from studies that have been associated with a lower total cancer incidence with the use of antioxidants [2], to studies that have highlighted the lack of any benefit of using antioxidants on the incidence of cancer [3]. All these results are, for certain ones, closely related with the type of antioxidant included in the study (alpha tocopherol, beta-carotene, ascorbic acid) and the investigated tumor location and not least the investigated pharmaceutical formulation. In this context, the use of antioxidants in the form of nanoparticles could improve the efficiency of this therapy due to specific surface area of nanostructures [4], thereby ensuring better contact with cells that would increase the chances of pathological angiogenesis inhibition. However, to have more success in cancer therapy, more studies should be conducted in this direction.Chitosan is a natural cationic polymer exhibits three chemical reactive sites including a primary amine and two primary or secondary hydroxyl groups for further modification [5][6][7]. Nano/microparticles coated with chitosan, synthesized through different techniques for encapsulation (chemical, physical and mechanical techniques), are in continuous development, aiming at the entrapment of bioactive substances, enzymes, hormones, antimicrobial agents, vitamins, mi...

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Section: In Vivo Evaluation Of Angiogenic Activity Using a Cam Modelmentioning

confidence: 99%

Designing of Chitosan Derivatives Nanoparticles with Antiangiogenic Effect for Cancer Therapy

et al. 2020

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“…The absorption bands at 1230 cm -1 and 937 cm -1 are due to the stretching of C-C bond and rocking vibration of CH 3 [42], respectively, which, although weak, can be found in the spectrum for composite membrane. For pure Para, the characteristic absorption peaks located at 3319 cm -1 and 1554 cm -1 are corresponding to -O-H group stretching and N-H group stretching, respectively [27].…”

Section: Ftir Analysis Of the Composite Membranementioning

confidence: 99%

“…In recent years, research has been directed towards improving comfort for patients with respect to pain when administrating treatment. Based on this, drug combination therapies have been put forward with the superiority of better analgesic effect when compared to monotherapy [27], whilst improving patient compliance and convenience [28]. Ibuprofen (IBU) is a widely used non-steroidal anti-inflammatory drug (NSAID) with very little side effects, which is used to treat pain and inflammation [29].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of flexible composite drug films via foldable linkages using electrohydrodynamic printing

Ahmad

et al. 2020

Materials Science and Engineering: C

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The simple method to manufacture a flexible multi-drug with hydrophilic and hydrophobic molecules-loaded composite membrane via three dimensional (3D) electrohydrodynamic (EHD) printing has been demonstrated in this study. The composite membrane consists of two different drug-loaded sections: cellulose acetateibuprofen (CA-IBU) and cellulose acetate-paracetamol (CA-Para), respectively, with an intermediate polycaprolactone (PCL) folding component. The composite membranes can be folded and housed in commercial capsules to aid swallowing. By changing the number of PCL layers in the intermediate layers, it is possible to control and modify the mechanical and unfolding properties of the composite membrane. IBU and Para are loaded into the CA polymeric matrix in their amorphous states, with the matrices exhibiting Higuchi and first order release kinetics, respectively. The combination of IBU and Para can potentially be used as analgesic for patients. Magnetic nanoparticles as a functional material can be incorporated into the PCL matrix for wide targeting and traceable applications. The composite membrane here possesses good biocompatibility and flexibility; enabling extensive application prospects in drug combination therapy and personalized medicine.

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Quality by Design Considerations for the Development of Lyophilized Products

Porfire

Tomuță

Iurian

et al. 2019

Pharmaceutical Quality by Design

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The influence of excipients on physical and pharmaceutical properties of oral lyophilisates containing a pregabalin-acetaminophen combination

Abstract: In the case of the investigated pharmaceutical formulations the study evidenced the assembling through physical bonds between the excipients and the 'codrug' complex, which do not affect the release of the bioactive compounds.

Cited by 8 publications

References 49 publications

Designing of Chitosan Derivatives Nanoparticles with Antiangiogenic Effect for Cancer Therapy

Designing of Chitosan Derivatives Nanoparticles with Antiangiogenic Effect for Cancer Therapy

Fabrication of flexible composite drug films via foldable linkages using electrohydrodynamic printing

Quality by Design Considerations for the Development of Lyophilized Products

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