The influence of exercise training versus intensive insulin therapy on insulin resistance development in type 1 diabetes

Dotzert, Michelle; McDonald, Matthew W.; Olver, T. Dylan; Sammut, Mitchell J.; Melling, C.W. James

doi:10.1016/j.jdiacomp.2022.108365

Cited by 2 publications

(4 citation statements)

References 25 publications

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“…The primary finding of the current study is that, similar to their male counterparts (35,(38)(39)(40)52), female rodents with T1DM develop IR. By the end of the study, DS animals exhibited nonfasting blood glucose measures significantly greater than all groups.…”

Section: Discussionmentioning

confidence: 74%

“…Our laboratory has previously shown increases in insulin-desensitizing lipid intermediates, such as diacylglycerol (90), in skeletal muscle following a hyperinsulinemic-9 Journal of Diabetes Research euglycemic clamp in male T1DM rodents using pre-and postclamp tissue analysis (40). This suggests that excess glucose is converted to lipid in skeletal muscle in T1DM through de novo lipogenesis (DNL) (91).…”

Section: Discussionmentioning

confidence: 99%

“…Exercise training has been shown to significantly increase insulin sensitivity and improve glucose homeostasis in patients with T1DM and animal models of this disease (35)(36)(37)(38)(39)(40)(41)(42)(43). Unfortunately, individuals with T1DM are largely inactive due to the fear of hypoglycemia, which is one of the largest barriers to exercise in this population, especially for those with IR (44)(45)(46).…”

Section: Introductionmentioning

confidence: 99%

“…Most work investigating IR in T1DM from a mechanistic standpoint has been conducted solely in males (35,(38)(39)(40)52), while very limited work has been conducted in females (53,54). The investigation of females with T1DM is war-ranted as it has been shown that sex differences exist in the metabolic effects of exercise (55,56).…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Resistance Exercise Training on Skeletal Muscle Metabolism and Insulin Resistance Development in Female Rodents with Type 1 Diabetes

Sammut,

McBey,

Sayal

et al. 2024

Journal of Diabetes Research

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The etiology of insulin resistance (IR) development in type 1 diabetes mellitus (T1DM) remains unclear; however, impaired skeletal muscle metabolism may play a role. While IR development has been established in male T1DM rodents, female rodents have yet to be examined in this context. Resistance exercise training (RT) has been shown to improve IR and is associated with a lower risk of hypoglycemia onset in T1DM compared to aerobic exercise. The purpose of this study was to investigate the effects of RT on IR development in female T1DM rodents. Forty Sprague Dawley eight-week-old female rats were divided into four groups: control sedentary (CS; n=10), control trained (CT; n=10), T1DM sedentary (DS; n=10), and T1DM trained (DT; n=10). Multiple low-dose streptozotocin injections were used to induce T1DM. Blood glucose levels were maintained in the 4-9 mmol/l range with intensive insulin therapy. CT and DT underwent weighted ladder climbing 5 days/week for six weeks. Intravenous glucose tolerance tests (IVGTT) were conducted on all animals following the six-week period. Results demonstrate that DS animals exhibited significantly increased weekly blood glucose measures compared to all groups including DT (p<0.0001), despite similar insulin dosage levels. This was concomitant with a significant increase in insulin-adjusted area under the curve following IVGTT in DS (p<0.05), indicative of a reduction in insulin sensitivity. Both DT and DS exhibited greater serum insulin concentrations compared to CT and CS (p<0.05). DS animals also exhibited significantly greater glycogen content in white gastrocnemius muscle compared to CS and DT (p<0.05), whereas DT and DS animals exhibited greater p-Akt: Akt ratio in the white vastus lateralis muscle and citrate synthase activity in the red vastus lateralis muscle compared to CS and CT (p<0.05). These results indicate that female rodents with T1DM develop poor glycemic control and IR which can be attenuated with RT, possibly related to differences in intramyocellular glycogen content.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Effects of Resistance Exercise Training on Skeletal Muscle Metabolism and Insulin Resistance Development in Female Rodents with Type 1 Diabetes

Sammut,

McBey,

Sayal

et al. 2024

Journal of Diabetes Research

Self Cite

View full text Add to dashboard Cite

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Mechanisms of insulin resistance in type 1 diabetes mellitus: A case of glucolipotoxicity in skeletal muscle

Sammut,

Dotzert,

Melling

2024

Journal Cellular Physiology

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Insulin resistance (IR), a hallmark of type 2 diabetes mellitus, develops in a significant number of patients with type 1 diabetes mellitus (T1DM) despite the use of insulin therapy to control glycemia. However, little is currently understood regarding the underlying mechanisms of IR in T1DM, especially within the context of chronic insulin treatment. Recent evidence suggests an important influence of glucolipotoxicity in skeletal muscle on insulin sensitivity in T1DM. Thus, this review summarizes our current knowledge regarding impairments in skeletal muscle lipid, glucose, and oxidative metabolism in the development of IR in insulin‐treated T1DM.

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The influence of exercise training versus intensive insulin therapy on insulin resistance development in type 1 diabetes

Cited by 2 publications

References 25 publications

The Effects of Resistance Exercise Training on Skeletal Muscle Metabolism and Insulin Resistance Development in Female Rodents with Type 1 Diabetes

The Effects of Resistance Exercise Training on Skeletal Muscle Metabolism and Insulin Resistance Development in Female Rodents with Type 1 Diabetes

Mechanisms of insulin resistance in type 1 diabetes mellitus: A case of glucolipotoxicity in skeletal muscle

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