A method to create synthetic mixtures that simulate the Exhaust Gas Recirculation (EGR) of an internal combustion engine, using O 2 , N 2 , CO 2 , H 2 O and Ar, has been designed. Different simplifications of this synthetic EGR error increases with temperature and decreases with pressure, equivalence ratio and oxygen mass fraction. Finally, the limit oxygen mass fractions for the use of each simplification have been obtained. Based on these results, it can be concluded that the only gas that can be obviated to keep the error in ignition delay under 1% is Ar.