The influence of experimental anterior knee pain during running on electromyography and articular cartilage metabolism

Denning, W. Matt; Woodland, Scott T.; Winward, Jason G.; Leavitt, Michael G.; Parcell, Allen C.; Hopkins, J. Ty; Francom, Devin; Seeley, Matthew K.

doi:10.1016/j.joca.2014.05.006

Cited by 17 publications

(14 citation statements)

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“…Fitting with previous research [15,17,19], the present results show that physical activity intensity influences the magnitude of serum COMP increase. The present results also indicate that serum COMP concentration returned to baseline no later than 30 min after ambulating 4000 steps, independent of ambulation speed.…”

Section: Discussionsupporting

confidence: 89%

“…In healthy subjects, previous serum COMP [18] and MRI data [28] suggest that increased serum COMP concentration reflects acute cartilage breakdown due to repetitive loads associated with ambulation. Also, increased serum COMP concentration is thought to indicate normal cartilage turnover [15,17,19]. Because our subjects were healthy and young, and the exercise interventions were low demand and of a short duration, we assume that the observed serum COMP increases represent normal cartilage metabolism.…”

Section: Discussionmentioning

confidence: 97%

“…For able-bodied individuals, serum COMP concentration increases in response to physical activity. This increase is believed to be determined by magnitude and duration of the physical activity, and represent the metabolic effect of exercise-induced load [15][16][17][18]. Relative to walking, greater serum COMP concentration has been observed after running for the same duration [17,19].…”

Section: Introductionmentioning

confidence: 99%

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Ambulation speed and corresponding mechanics are associated with changes in serum cartilage oligomeric matrix protein

et al. 2016

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Because serum cartilage oligomeric matrix protein (COMP) has been used to reflect articular cartilage condition, we aimed to identify walking and running mechanics that are associated with changes in serum COMP. Eighteen subjects (9 male, 9 female; age=23 ± 2 yrs.; mass=68.3 ± 9.6 kg; height=1.70 ± 0.08 m) completed 4000 steps on an instrumented treadmill on three separate days. Each day corresponded to a different ambulation speed: slow (preferred walking speed), medium (+50% of slow), and fast (+100% of slow). Synchronized ground reaction force and video data were collected to evaluate walking mechanics. Blood samples were collected pre-, post-, 30-minute post-, and 60-minute post-ambulation to determine serum COMP concentration at these times. Serum COMP increased 29%, 18%, and 5% immediately post ambulation for the fast, medium, and slow sessions (p<0.01). When the speeds were pooled, peak ankle inversion, knee extension, knee abduction, hip flexion, hip extension, and hip abduction moment, and knee flexion angle at impact explained 61.4% of total variance in COMP concentration change (p<0.001). These results indicate that (1) certain joint mechanics are associated with acute change in serum COMP due to ambulation, and (2) increased ambulation speed increases serum COMP concentration.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Ambulation speed and corresponding mechanics are associated with changes in serum cartilage oligomeric matrix protein

et al. 2016

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“…Results demonstrated a significant increase in serum COMP, which remained elevated for 2 h post, but had returned to baseline within 24 h. Prolonged bouts of acute running, i.e., following running a marathon has been associated with a 24–60% (Neidhart et al 2000; Kim et al 2009), increase in COMP. In healthy individuals, 30 min of running exercise has been associated with a 16–36% increase in COMP (Denning et al 2014; Firner et al 2018). Thus, COMP appears to respond in a ‘dose dependent’ fashion to acute exercise bouts (Neidhart et al 2000; Mündermann et al 2005; Kersting et al 2005; Kim et al 2009; Niehoff et al 2010).…”

Section: Acute Serum Biomarker Response To Joint Loadingmentioning

confidence: 99%

The time course and mechanisms of change in biomarkers of joint metabolism in response to acute exercise and chronic training in physiologic and pathological conditions

2019

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PurposeThe benefits of exercise across the lifespan and for a wide spectrum of health and diseases are well known. However, there remains less clarity as to the effects of both acute and chronic exercise on joint health. Serum biomarkers of joint metabolism are sensitive to change and have the potential to differentiate between normal and adverse adaptations to acute and chronic load. Therefore, the primary objective of this review is to evaluate how serum biomarkers can inform our understanding of how exercise affects joint metabolism.MethodsA comprehensive literature search was completed to identify joint biomarkers previously used to investigate acute and chronic exercise training.ResultsIdentified biomarkers included those related to joint cartilage, bone, synovium, synovial fluid, and inflammation. However, current research has largely focused on the response of serum cartilage oligomeric matrix protein (COMP) to acute loading in healthy young individuals. Studies demonstrate how acute loading transiently increases serum COMP (i.e., cartilage metabolism), which is mostly dependent on the duration of exercise. This response does not appear to be associated with any lasting deleterious changes, cartilage degradation, or osteoarthritis.ConclusionSeveral promising biomarkers for assessing joint metabolism exist and may in future enhance our understanding of the physiological response to acute and chronic exercise. Defining ‘normal’ and ‘abnormal’ biomarker responses to exercise and methodological standardisation would greatly improve the potential of research in this area to understand mechanisms and inform practice.

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“…However, the increase in VM EMG activation during the stair ascent task performed after the loading protocol did not correlate with the increase in pain. Denning et al [ 48 ] have found that experimentally-induced knee pain during running actually decreased VM and VL EMG amplitude. As such, pain itself might not be responsible for the increase in VM EMG amplitude found in the present study.…”

Section: Discussionmentioning

confidence: 99%

Quadriceps neuromuscular function in women with patellofemoral pain: Influences of the type of the task and the level of pain

Briani¹,

Silva²,

Flóride³

et al. 2018

PLoS ONE

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The present study aimed at investigating whether the neuromuscular system behaves differently (in terms of force and muscle activity generation) as a function of the task being performed (i.e. maximal voluntary efforts vs stair negotiation) and the presence of patellofemoral pain (PFP) and possible influences of pain intensity. Thirty-eight women with (n = 19) and without PFP (n = 19) had their knee strength (extension joint torque) measured during maximal voluntary isometric contractions (MVIC) and electromyography (EMG) data recorded during both MVIC and stair ascent tasks, which were performed before and after a loading protocol designed to exacerbate pain symptoms. Women with PFP displayed lower levels of vastus medialis (p = 0.002) and vastus lateralis (p = 0.032) EMG activation during MVIC assessments. Conversely, the PFP group showed higher levels of vastus medialis muscle activity during stair climbing (p = 0.007), which happened exclusively after the loading protocol. Similarly, women with PFP displayed lower knee extensor torque only during the MVIC tests performed after the loading protocol, which was moderately correlated with the increase in self-reported pain (p = 0.041, r = 0.37), whereas the changes in EMG activity during stair ascent were not correlated with changes in pain intensity (p = 0.215, r = 0.12). These results suggest that, in comparison to pain-free controls, women with PFP display lower levels of quadriceps EMG activation during maximal contractions, but higher activation during dynamic tasks (stair ascent). In addition, the moderate association between the decrease in knee extensor torque and increase in self-reported pain indicates that care should be taken by clinicians during quadriceps strength evaluation in women with PFP, as misleading outcomes may emerge if the intensity of knee pain is not considered during screening. Additionally, rehabilitation strategies should focus on both restoring neuromuscular control and increasing muscle strength.

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The influence of experimental anterior knee pain during running on electromyography and articular cartilage metabolism

Abstract: During a 30-min run, AKP acutely alters midstance VM, VL, and GA EMG amplitude. AKP during a 30-min run does not, however, acutely influence articular cartilage metabolism.

Cited by 17 publications

References 50 publications

Ambulation speed and corresponding mechanics are associated with changes in serum cartilage oligomeric matrix protein

Ambulation speed and corresponding mechanics are associated with changes in serum cartilage oligomeric matrix protein

The time course and mechanisms of change in biomarkers of joint metabolism in response to acute exercise and chronic training in physiologic and pathological conditions

Quadriceps neuromuscular function in women with patellofemoral pain: Influences of the type of the task and the level of pain

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