The influence of familial predisposition to cardiovascular complications upon childhood obesity treatment

The effect of impaired glucose metabolism on weight loss in multidisciplinary childhood obesity treatment

“…Girls with higher concentrations of HbA1c at treatment entry were more obese at treatment entry. A previous report from our group has demonstrated that children with a familial predisposition to T2DM have a higher degree of obesity at treatment initiation . In addition, Altinli et al observed that children with parents with T2DM exhibits a higher degree of obesity compared to children with parents without diabetes .…”

“…Difficulties in achieving weight loss during chronic care treatment have been reported to be associated with higher age, higher degree of obesity at treatment initiation, 4,5 insulin resistance, and parental obesity. 40 In contrast to these reports, the TCOCT protocol has attained a significant and biologically relevant 47 weight loss in elder children (age above 11.7 years), 22 and further documented that girls with familial predisposition to obesity lost more weight than girls without familial predisposition to obesity 35 and that parents reduced their degree of obesity during their child's treatment with the TCOCT protocol. 28 In addition, the present study shows that weight loss is attainable in children and adolescents with obesity and impaired glucose metabolism irrespective of age, degree of obesity, and SES.…”

“…A previous report from our group has demonstrated that children with a familial predisposition to T2DM have a higher degree of obesity at treatment initiation. 35 In addition, Altinli et al observed that children with parents with T2DM exhibits a higher degree of obesity compared to children with parents without diabetes. 36 We did not investigate whether or not the girls with high…”