The influence of food on the oral bioavailability of terazosin [letter]

SummaryThe bioavailability of and pharmacodynamic responses to doxazosin, administered with and without food, were examined in a crossover study in 12 hypertensive subjects. The administration of doxazosin with food delayed its absorption by approximately I hour, reduced the maximum (peak) plasma drug concentration after single dose administration (Cmax) by 18%, and reduced the area under the plasma concentration-time curve (AUC) by 12%; however, these effects were not statistically significant. The acute fall in blood pressure following doxazosin administration was not significantly affected by food; however, there was a trend towards a lower incidence of complaints in this group. The effect of coadministration of food on the pharmacokinetic and pharmacodynamic responses to doxazosin are unlikely to be of clinical significance.

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Medication and food issues for overactive bladder/lower urinary tract symptoms: When do we eat?

Maltz¹,

Zoltan

2009

Curr Bladder Dysfunct Rep

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Overactive bladder (OAB) and lower urinary tract symptoms (LUTS) are common conditions that often require chronic medications. Treatment for OAB includes older antimuscarinic agents (oxybutynin) and newer agents (tolterodine, trospium chloride, darifenacin, and solifenacin). Treatment for LUTS includes the 5-α reductase inhibitors, (fi nasteride and dutasteride) and α1-adrenergic antagonists (prazosin, doxazosin, terazosin, alfuzosin, and tamsulosin). Many medications have the potential to interact with food. This article addresses the effects of food on the current treatments for OAB and LUTS and the clinical considerations for their optimal dosing with regard to food.

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The influence of food on the oral bioavailability of terazosin [letter]

Cited by 5 publications

References 6 publications

Drug-Food Interactions Affecting Drug Absorption

Drug-Food Interactions Affecting Drug Absorption

The Effects of Food on the Oral Bioavailability of Doxazosin in Hypertensive Subjects

Medication and food issues for overactive bladder/lower urinary tract symptoms: When do we eat?

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