The influence of gender and atopy on the natural history of rhinitis in the first 18 years of life

Kurukulaaratchy, Ramesh; Karmaus, Wilfried; Raza, Abid; Matthews, S.; Roberts, Graham; Arshad, Syed Hasan

doi:10.1111/j.1365-2222.2011.03765.x

Cited by 91 publications

(117 citation statements)

References 25 publications

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“…In the case of asthma, a change in sex predominance favoring females has been observed with the transition from childhood to adulthood [3,5]. Because asthma and rhinitis coexist more often than expected [48], we hypothesized that rhinitis may also undergo similar sex reversal during puberty [49]. Our results support this hypothesis, though they failed to show a female predominance in adulthood, likely due to the limited studies found in adults.…”

Section: Discussionsupporting

confidence: 75%

Sex-Related Allergic Rhinitis Prevalence Switch from Childhood to Adulthood: A Systematic Review and Meta-Analysis

Pinart¹,

Keller

Reich

et al. 2017

Int Arch Allergy Immunol

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Background: A sex-related switch in the prevalence of asthma from childhood (male predominance) to adulthood (female predominance) has been described, but for allergic rhinitis this remains unclear. We aimed to examine sex- and age-group-specific differences in allergic rhinitis prevalence by systematically evaluating studies from across the globe. Methods: A systematic search of MEDLINE and Embase for population-based cross-sectional studies was performed regardless of the language of publication. The search was restricted to the present millennium (2000 to June 2014). Study quality was defined by the sampling method, response rate, sample size, and data collection method. To assess sex differences in the prevalence of self- or parent-reported symptoms of rhinitis, calculated pooled estimates of the male-female ratio (MFR) were obtained using random-effects model meta-analyses due to heterogeneity. A meta-regression analysis was also performed. Results: Out of 6,539 publications identified, 67 cross-sectional population-based studies (291,726 males and 301,781 females) were included in our meta-analysis. In children (<11 years of age) significantly more boys than girls had rhinitis symptoms (MFR 1.21, 95% CI 1.17-1.25), whereas in adolescents (11 to <18 years of age) males were significantly less often affected than females (MFR 0.90, 95% CI 0.85-0.95). No sex-specific prevalence difference was observed in adults (MFR 0.96, 95% CI 0.83-1.17). These findings were consistent in all continents except in Asia, where the male predominance remained beyond childhood. Conclusions: The male predominance of rhinitis prevalence in childhood changed towards a female predominance in adolescence across the globe, except in Asia. Longitudinal studies are needed to confirm these cross-sectional data and examine possible determinants and underlying mechanisms.

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Section: Discussionsupporting

confidence: 75%

Sex-Related Allergic Rhinitis Prevalence Switch from Childhood to Adulthood: A Systematic Review and Meta-Analysis

Pinart¹,

Keller

Reich

et al. 2017

Int Arch Allergy Immunol

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“…The 1989 Isle of Wight birth cohort of 1456 children had prevalences of 2.8 and 11.8% at 4 and 18 years for rhinitis in nonsensitized individuals with figures of 3.4 and 27.3% for those who were sensitized (19). There was a male predominance of allergic rhinitis and female predominance of nonallergic rhinitis during adolescence.…”

Section: Prevalence and Epidemiologymentioning

confidence: 96%

“…Measurement of total serum IgE has little value in assessing allergic aetiology of rhinitis in childhood. The presence of sensitization is a major risk factor for AR in children (19,51). Outdoor allergens constitute a risk of seasonal rhinitis, whereas indoor allergens are associated with perennial rhinitis (52).…”

Section: Defining the Presence Of Allergymentioning

confidence: 99%

Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology

Roberts

Xatzipsalti

Borrego

et al. 2013

Allergy

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317

248

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Rhinitis is a common problem in childhood and adolescence and impacts negatively on physical, social and psychological well-being. This position paper, prepared by the European Academy of Allergy and Clinical Immunology Taskforce on Rhinitis in Children, aims to provide evidence-based recommendations for the diagnosis and therapy of paediatric rhinitis. Rhinitis is characterized by at least two nasal symptoms: rhinorrhoea, blockage, sneezing or itching.

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“…Another study reported the effects of parental history of asthma on the development of childhood asthma, independently of atopic status. 41 …”

Section: Atopic Mtwmentioning

confidence: 97%

Novel severe wheezy young children phenotypes: Boys atopic multiple-trigger and girls nonatopic uncontrolled wheeze

Just

Gouvis-Echraghi

Couderc

et al. 2012

Journal of Allergy and Clinical Immunology

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The influence of gender and atopy on the natural history of rhinitis in the first 18 years of life

Abstract: A better understanding of how gender and atopic status influence rhinitis during adolescence emerges from this study. Application of such knowledge could help to improve clinical recognition, judge prognosis and ultimately improve management of this common condition.

Cited by 91 publications

References 25 publications

Sex-Related Allergic Rhinitis Prevalence Switch from Childhood to Adulthood: A Systematic Review and Meta-Analysis

Sex-Related Allergic Rhinitis Prevalence Switch from Childhood to Adulthood: A Systematic Review and Meta-Analysis

Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology

Novel severe wheezy young children phenotypes: Boys atopic multiple-trigger and girls nonatopic uncontrolled wheeze

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