The influence of gender on the epidemiology of and outcome from severe sepsis

Sakr, Yasser; Elia, Cristina; Mascia, Luciana; Barberis, B; Cardellino, Silvano; Livigni, Sergio; Fiore, Gilberto; Filippini, Claudia; Ranieri, V. Marco

doi:10.1186/cc12570

Cited by 149 publications

(134 citation statements)

References 30 publications

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“…7 The fact that the occurrence is higher in male compared to female may be explained by a combination of differences in chronic disease burden, particularly subclinical disease, social and environmental factors, and genetic predisposing causing difference in the host immune response towards infection that likely contributes to the observed difference. For example, a few healthy female volunteers showed a more pronounced pro-inflammatory response after endotoxin infusion compared to healthy men.…”

Section: Discussionmentioning

confidence: 99%

Pathogen Profile of Patients with Sepsis in Internal Medicine, Dr. Hasan Sadikin General Hospital, Bandung 2013

Fauzi¹,

Sumardi²,

Tristina³

2016

amj

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Background: Sepsis is a continuous disease which begins with systemic inflammatory response syndrome (SIRS), seen in association with a large number of clinical conditions. These include infectious insults that produce SIRS, such as pancreatitis, ischemia, multiple traumas and tissue injury, hemorrhagic shock, immunemediated organ injury, and the exogenous administration of such putative mediators of the inflammatory process as tumor necrosis factor and other cytokines. A frequent complication of SIRS is the development of organ system dysfunction, including such well-defined clinical conditions as acute lung injury, shock, renal failure, and multiple organ dysfunction syndrome (MODS). Hence, this study was conducted to identify the pathogen profile that often causes sepsis. Methods: A retrospective study was performed to 152 medical records of patients diagnosed as sepsis from Internal Medicine Department Dr. Hasan Sadikin General Hospital from January 2013 to December 2013. The variables observed from the medical records were age, sex, comorbidity, main infection, culture sample, type of gram bacteria, resistant bacteria, and antibiotic susceptibility test. After data collection was completed, the data were analyzed using computer. The data were presented in percentage. Results: Sepsis in male was higher than female. Highest comorbid was chronic kidney disease (CKD). The main infection was health care acquired pneumonia (HCAP). Highest pathogen that caused sepsis was Escherichia coli and highest multidrug-resistant organism (MDRO) was extended spectrum beta-lactamase (ESBL) Escherichia coli. Conclusions:The most common pathogen that causes sepsis is Escherichia coli.

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Section: Discussionmentioning

confidence: 99%

Pathogen Profile of Patients with Sepsis in Internal Medicine, Dr. Hasan Sadikin General Hospital, Bandung 2013

Fauzi¹,

Sumardi²,

Tristina³

2016

amj

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“…Mortality was the same for both genders (15). Sakr et al (16) reported higher mortality in female patients with severe sepsis, but no difference in time to antibiotics. In order to understand the reason for gender differences in treatment between male and female septic patients, …”

Section: November 2015mentioning

confidence: 99%

Timing of Antibiotic Treatment in a Swedish Cohort of Septic Intensive Care Patients

Cronhjort¹,

Rysz²,

Sandström³

et al. 2015

J Anesth Perioper Med

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Background: Sepsis is a challenge to healthcare systems, and morbidity and mortality remain high. In the worldwide Surviving Sepsis Campaign, there has been a focus on the timing of antibiotic administration to septic patients. The objective of this study was to describe current practice regarding the timing of antibiotic administration in septic patients admitted to intensive care units (ICUs) in Sweden. Methods: This was an observational cohort study of septic patients in four ICUs in the Stockholm area during 2005-2010. Inclusion criteria were age > 18 years, sepsis upon hospital admission, and a registered time point for the first dose of antibiotic administration. Information on time of arrival at the hospital, physiological parameters within the first hour of arrival, time of administration of antibiotics, results of blood culture, other laboratory results, diagnosis, and medical procedures were retrieved from the medical charts. Patients requiring surgery for source control were labelled as having surgical sepsis. Results: Overall, 64 of 210 septic patients (30% ) received antibiotics within one hour of hospital admission. Initiation of antimicrobial therapy was delayed in female patients. Surgical patients received antibiotics later but still had a lower mortality than non-surgical patients. Conclusions:The reason for the delay of antibiotics to female patients and the impact on clinical outcomes of such a gender difference in the treatment of sepsis needs to be further investigated.

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“…A incidência de sepse aumenta desproporcionalmente em adultos mais velhos e mais da metade dos casos de sepse ocorre em adultos com mais de 65 anos de idade (12) . As mulheres parecem estar em menor risco de desenvolver sepse do que os homens (13) . Os pacientes que sobrevivem à sepse são mais propensos a serem internados em cuidados intensivos e / ou centros de cuidados prolongados no primeiro ano após a internação inicial e também parecem ter uma diminuição persistente na qualidade de vida (14)(15)(16)(17) .…”

Section: Introductionunclassified

Diagnóstico De Sepse Em Pacientes Após Internação Em Unidade De Terapia Intensiva

Moura¹,

Sanches²,

Pereira³

et al. 2017

ACS

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Conflito de interesses:Não Contribuição dos autores: JMM coleta, tabulação, delineamento do estudo e redação do manuscrito. EBS delineamento do estudo. RAPM delineamento do estudo e elaboração do manuscrito. ISF orientação do projeto, discussão dos achados, etapas de execução e elaboração do manuscrito, delineamento do estudo e elaboração do manuscrito. LMC orientação do projeto, delineamento do estudo e elaboração do manuscrito. ALW orientação do projeto, discussão dos achados, etapas de execução e elaboração do manuscrito, delineamento do estudo e elaboração do manuscrito. Contato para correspondência: Joice Marques Moura E-mail: joice_aww@hotmail. AbstractIntroduction: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Patients with sepsis (formerly called severe sepsis) should still be identified by the same organ dysfunction criteria (including lactate level greater than 2 mmol/L). Organ dysfunction may also be identified in the future using the quick Sepsis-Related Organ Failure Assessment (qSOFA). Currently, sepsis is one of the main causes of mortality in Intensive Care Units. In 2003, the Sepsis Surviving Campaign was created, elaborating a schedule of actions to reduce the incidence of sepsis, especially in intensive care units. Objective: To know the clinical characteristics and outcome of patients who developed sepsis during Intensive Care Units admission. Material and Methods: This is a retrospective, descriptive study using a quantitative approach performed at the Intensive Care Units. Data were obtained through an electronic medical record. The software Epi Info, version 7.2.1.0 was used to analyze data. Results:The largest number of patients hospitalized was male, aged from 51 to 70 years. The most common comorbidities were Systemic Hypertension, Diabetes Mellitus, alcoholism, smoking, and heart disease. The most analyzed post-sepsis outcome was discharge from Intensive Care Units, and the patients were considerably males. Conclusion: We conclude that the patients who most developed sepsis were men (62%), aged ranging from 51 to 70 years (36%). The main comorbidity was systemic hypertension (42%) and the most observed outcome was discharge from the Intensive Care Units (67%). consenso e novas definições de sepse foram publicadas, conhecidas como Sepsis 3, definida pela "presença de disfunção orgânica ameaçadora à vida secundária à resposta desregulada do organismo à infecção" (2) . Para avaliação do diagnóstico clínico de disfunção or gânica, atualmente são observados uma variação de dois ou mais pontos no escore Sequential Organ Failure Assessment (SOFA). Os critérios da síndrome da resposta inflamatória sistêmica (SRIS) não são mais usados para a definição. Os casos de sepse passam a ser considerados como doença grave, assim, não se usa mais a expressão "sepse grave". Choque séptico é definido como "um subgrupo dos pacientes com sepse que apresentam acentuadas anormalidades circulatórias, celulares e metabólicas e associadas com maio...

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The influence of gender on the epidemiology of and outcome from severe sepsis

Cited by 149 publications

References 30 publications

Pathogen Profile of Patients with Sepsis in Internal Medicine, Dr. Hasan Sadikin General Hospital, Bandung 2013

Pathogen Profile of Patients with Sepsis in Internal Medicine, Dr. Hasan Sadikin General Hospital, Bandung 2013

Timing of Antibiotic Treatment in a Swedish Cohort of Septic Intensive Care Patients

Diagnóstico De Sepse Em Pacientes Após Internação Em Unidade De Terapia Intensiva

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