The Influence of Glomerular Filtration Rate, Solute Excretion and Hydration on the Concentrating Mechanism of the Experimentally Diseased Kidney in the Dog *

Ns, Bricker; Sw, Kime; Pa, Morrin; Orłowski, T

doi:10.1172/jci104107

Cited by 26 publications

(11 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several of the major findings presented here such as increased fractional sodium and free water excretion, but diminished TCH20 formation in the experimental kidney bear an interesting similarity to those reported by Bricker and his associates in some of their studies (24,25). These workers produced a variety of unilateral renal lesions including pyelonephritis and aminonucleoside nephritis.…”

Section: Resultssupporting

confidence: 87%

The postobstructive kidney. Observations on nephron function after the relief of 24 hr of ureteral ligation in the dog

Bercovitch¹,

Kasen²,

Blann³

et al. 1971

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T After the relief of 24 hr of complete unilateral ureteral obstruction in the dog, the experimental kidney is characterized by a decrease in filtration rate and an increase in fractional and often absolute excretion of sodium before and after the administration of mannitol. In the hydrated state, the failure to conserve sodium is associated with increases in fractional free water clearance and fractional sodium supply to waterfreeing sites signifying that the augmented sodium excretion is derived from a proximal source. In the hydropenic state there is decreased fractional free water reabsorption, and sometimes free water excretion, in the postobstructive kidney. An early plateau in free water reabsorption is associated with an increased fractional excretion of sodium. These findings are attributed to the early development of distal nephron impermeability to water as a result of enhanced distal tubular supply and transport of sodium. There is a decrease in maximal tubular reabsorptive capacity (Tm) of glucose in the postobstructive kidney which is, however, less marked than the decrease in filtration rate. The fall in filtration rate is to some extent likely due to a dropping out of nephrons from the circulation while the remaining nephrons are hypoperfused. The magnitude of the sodium reabsorptive defect is markedly exaggerated as the concentration of nonreabsorbable solute (mannitol) in the glomerular perfusate is increased. It is concluded that the postobstructive increase in sodium excretion during mannitol adThis work was presented at

show abstract

Section: Resultssupporting

confidence: 87%

The postobstructive kidney. Observations on nephron function after the relief of 24 hr of ureteral ligation in the dog

Bercovitch¹,

Kasen²,

Blann³

et al. 1971

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…Because of the probability that the number of functioning nephrons was considerably reduced in the hypercalcemic rats (zide infra), sodium excretion was factored by GFR in Figure 3 in order to evaluate the capacity of residual intact nephrons to reabsorb sodium at comparable osmotic loads per nephron (Cosm/100 ml GFR). The evidence that GFR in a diseased kidney provides an index of the population of residual functioning nephrons has been presented by Bricker, Kime, Morrin, and Orlowski (15). This analysis suggests that overall sodium reabsorption was not impaired in intact nephrons of the hypercalcemic rats.…”

Section: Methodsmentioning

confidence: 90%

On the Mechanism of Hyposthenuria in Hypercalcemia*

Bank¹,

Aynedjian²

1965

J. Clin. Invest.

View full text Add to dashboard Cite

“…Although altered renal transport of sodium in chronic renal failure is well known and has been the subject of intensive investgation (1)(2)(3)(4)(5)(6)(7)(8)(9)(17)(18)(19), the manner by wnvhich this change in renal handling of sodium takes place at various sites of the nephron has not been elucidated. Micropuncture studies performed in the past using various experimental models have centered mostly on the transport changes in the proximal tubule (5)(6)(7)(8) and rarely in the distal segments (9).…”

Section: Discussionmentioning

confidence: 99%

Micropuncture Studies of Sodium Tranport in the Remnant Kidney of the Dog THE EFFECT OF GRADED VOLUME EXPANSION

Wen¹,

Wong²,

Evanson³

et al. 1973

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T Proximal and distal tubule micropuncture studies were performed to examine the response to graded extracellular volume (ECV) expansion in 10 normal dogs (stage I), 11 dogs with a unilateral remnant kidney (stage II), and 7 dogs with a remnant kidney after removal of the contralateral kidney (stage III). Before ECV expansion in stage III, there was a suggestive reduction in proximal tubule as well as loop fractional reabsorption of sodium. After ECV expansion to 3% body weight proximal tubule reabsorption was depressed in all groups of animals, while little further inhibition was observed in this segment with additional expansion to 10% body weight. In contrast, the fraction of filtered sodium remaining in the distal tubule rose progressively in all three groups after graded ECV expansion, suggesting that the graded natriuretic response found in the final urine was largely due to a similar response in the loop of Henle rather than that in the proximal tubule. The distal tubule response of the remnant kidney in both stages II and III was greater than that in stage I. These data indicate that although enhanced sodium excretion per nephron in chronic renal failure may be related to uremia, its exaggerated response to ECV expansion is due, at least in part, to cer-

show abstract

The Influence of Glomerular Filtration Rate, Solute Excretion and Hydration on the Concentrating Mechanism of the Experimentally Diseased Kidney in the Dog *

Cited by 26 publications

References 12 publications

The postobstructive kidney. Observations on nephron function after the relief of 24 hr of ureteral ligation in the dog

The postobstructive kidney. Observations on nephron function after the relief of 24 hr of ureteral ligation in the dog

On the Mechanism of Hyposthenuria in Hypercalcemia*

Micropuncture Studies of Sodium Tranport in the Remnant Kidney of the Dog THE EFFECT OF GRADED VOLUME EXPANSION

Contact Info

Product

Resources

About