The influence of glucose load on metabolism during minor surgery using remifentanil-induced anesthesia

Kambe, Noriko; Tanaka, Katsuya; Kakuta, Nami; Kawanishi, Ryosuke; Tsutsumi, Yasuo M.

doi:10.1111/aas.12335

Cited by 13 publications

(22 citation statements)

References 25 publications

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“…However, no significant differences were observed among the three groups. In previous studies, the plasma levels of ketone bodies and FFA were used to assess fat catabolism [1][2][3][4][5][6][7]. Similarly, we evaluated ketone bodies and FFA in the present study as well.…”

Section: Figurementioning

confidence: 98%

“…Previous studies have demonstrated the inhibition of catabolism by the administration of glucose under general doi: 10.7243/2049-9752-6-1 anaesthesia at a rate of 0.07-0.25 g/kg/ h [1][2][3][4][5][6][7], whereas hyperglycaemia was detected in studies in which more than 0.15 g/kg/h of glucose were administered. We demonstrated that the mean energy expenditure (EE) value of operative patients was 17.7kcal/kg/day in a previous study [17].…”

Section: Figurementioning

confidence: 99%

“…Similarly, we evaluated ketone bodies and FFA in the present study as well. On the other hand, the plasma BCAA, 3-MH, or 3-MH/Cr levels or urinary 3-MH/Cr levels were used to assess muscle catabolism [2][3][4][5][6][7]; in other words, the previous studies used different indexes. We used the plasma BCAA and 3-MH/Cr levels to assess muscle catabolism.…”

Section: Figurementioning

confidence: 99%

“…Yamasaki K et al [5] showed that the plasma 3-MH level of a group in which glucose was administered (0.07 g/kg/h) after overnight fasting was significantly decreased after surgery. On the other hand, some studies have shown that the administration of glucose during surgery did not affect the urinary 3-MH or 3-MH/Cr levels [3,6,7]. Thus, Kanbe N et al [7] proposed that 3-MH may not have been the most appropriate index of the degree of protein catabolism.…”

Section: Figurementioning

confidence: 99%

“…Some previous studies have shown that the administration of glucose during surgery can inhibit starvation-induced catabolism [1][2][3][4][5][6][7] and attenuate post-operative insulin resistance [8]. Furthermore, the degree of postoperative insulin resistance was found to be an independent factor associated with the length of the postoperative hospital stay [9].…”

Section: Introductionmentioning

confidence: 99%

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Administration of low dose of glucose suppresses catabolism under general anaesthesia maintained with remifentanil

Yoshimura¹,

Tomita²,

Kusama³

et al. 2017

J Anesthesiol Clin Sci

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Background: The aim of this prospective randomized controlled study was to examine the optimal rate of glucose administration for preventing catabolism under general anaesthesia maintained with remifentanil. Methods: Forty-five consecutive patients who were scheduled to undergo elective head and neck surgery were enrolled. The patients were divided into three groups and were treated with a glucose-free solution (Group G0) or a glucose solution at a rate of 0.07 g/kg/h (Group G1) or 0.14 g/kg/h (Group G2). The patients' plasma glucose, the plasma levels of ketone bodies, free fatty acids (FFA), 3-methylhistidine (3-MH), creatinine (Cr), Branched-Chain Amino Acid (BCAA), and stress hormones were measured every two hours until 6h (T6). Results:The plasma glucose levels of Group G2 were significantly higher than those of the other groups at T2, T4, and T6 (P<0.01); however, the plasma glucose levels of the three groups did not differ at POD1. Group G0 exhibited significantly higher plasma ketone body and BCAA levels (at T2, T4, and T6) and FFA levels (at T4 and T6). No significant inter-group differences in the plasma levels of 3-MH/Cr or stress hormones were observed. Conclusions: Intraoperative glucose administration at a rate of 0.07 g/kg/h under general anaesthesia inhibited catabolism without the risk of hyperglycaemia.

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Section: Figurementioning

confidence: 98%

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Administration of low dose of glucose suppresses catabolism under general anaesthesia maintained with remifentanil

Yoshimura¹,

Tomita²,

Kusama³

et al. 2017

J Anesthesiol Clin Sci

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The effect of perioperative glucose control on postoperative insulin resistance

et al. 2012

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Jelly-type carbohydrate supplement in healthy subjects suppresses the catabolism of adipose tissue and muscle protein and improves their satisfactions

Oyama¹,

Kakuta²,

Mita

et al. 2018

Clinical Nutrition Experimental

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Background & aims: Many studies have reported the effects of preoperative clear fluid carbohydrate supplements; however, few studies have reported the effects of preoperative jelly-type carbohydrate supplements. This study aimed to assess the effect of a jelly-type oral nutritional supplement (ONS) on metabolism, redox balance by using various surrogate markers and to evaluate its excretion from the stomach. Methods: This study was conducted according to a crossover design. Participants underwent a control experiment whereby they fasted after dinner and only ingested water until the experiment. The remaining participants underwent an ONS experiment whereby they ingested 400 g of ONS before bed and another 400 g at 7:00 am. Blood samples were collected at 9:00 am. After a break of at least 24 h, participants underwent the alternate experiment. Results: Thirty minutes after intake of jelly, the gastric antrum appeared flat (the same result as that at baseline) on ultrasonography. The ONS group showed significantly lower serum free fatty acid levels (100 mEq/L, p ¼ 0.027, vs. 327 mEq/L, n ¼ 6), total ketone bodies levels, 3-MH/creatinine levels, and oxidative stress surrogate * This study was approved by the Human Research Ethics Committee of the University of Tokushima and registered in a clinical trials database (UMIN000024024).

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The influence of glucose load on metabolism during minor surgery using remifentanil-induced anesthesia

Abstract: Infusion of low-dose glucose attenuated fat catabolism without causing hyperglycemia, indicating that infusion of low-dose glucose during remifentanil-induced anesthesia may be safe for patients.

Cited by 13 publications

References 25 publications

Administration of low dose of glucose suppresses catabolism under general anaesthesia maintained with remifentanil

Administration of low dose of glucose suppresses catabolism under general anaesthesia maintained with remifentanil

The effect of perioperative glucose control on postoperative insulin resistance

Jelly-type carbohydrate supplement in healthy subjects suppresses the catabolism of adipose tissue and muscle protein and improves their satisfactions

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