2016
DOI: 10.13181/mji.v25i2.1308
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The influence of glutathion S-transferase P-1 polymorphism A313G rs1695 on the susceptibility to cyclophosphamide hematologic toxicity in Indonesian patients

Abstract: ABSTRAK ABSTRACTBackground: Chemotherapy often causes side effects such as hematologic toxicity. The degree of toxicity is often associated with genetic polymorphism. This study aims to determine the influence of GSTP1 A313G polymorphism, an enzyme responsible for detoxifying cyclophosphamid, on incidence and severity of cyclophosphamid hematologic toxicity.

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Cited by 6 publications
(8 citation statements)
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“…The annealing stage was run for 30 seconds at 72 °C extension stage, and then it was followed for 45 seconds at 72 °C, and finally was performed for elongation for 10 minutes at 72 °C in 35 cycles. 16 The amplifying process for GSTP1 A313G was performed as per Hasni et al 10 …”
Section: Methodsmentioning
confidence: 99%
See 3 more Smart Citations
“…The annealing stage was run for 30 seconds at 72 °C extension stage, and then it was followed for 45 seconds at 72 °C, and finally was performed for elongation for 10 minutes at 72 °C in 35 cycles. 16 The amplifying process for GSTP1 A313G was performed as per Hasni et al 10 …”
Section: Methodsmentioning
confidence: 99%
“… 4 , 15 The pattern for GSTP1 A313G has two bands (292 and 132 bp) for homozygous AA, four fragments for heterozygous AG (292, 222, 132, and 70 bp), and three fragments for variant homozygous GG (222, 132, and 70 bp). 10 …”
Section: Methodsmentioning
confidence: 99%
See 2 more Smart Citations
“…It is estimated that in 2030, COPD will rank third as the leading cause of death (Adeloye et al, 2015;Mathers & Loncar, 2006) The prevalence of COPD in Indonesia is 3.7% of the total population and 3.0% in West Sumatra. (Naser , Medison, & Erly, 2016; RISKESDAS, 2013) Smoking is not the only cause of COPD, some previous studies have stated that exposure to smoke using kerosene at home, dust in the workplace, or at home can be a risk factor for occurrence COPD even though the patient has never smoked (Kurmi, Lam, & Ayres, 2012; Mahmood et al, 2017; Ngahane et al, 2015) even genetic is estimated to play a role in the occurrence of diseases today (Hasni, Siregar, & Lim, 2016;Lakhdar et al, 2010). The prevalence of COPD in the non-proxies group has been carried out several studies in various countries, in Japan by 34% (Takiguchi et al, 2018), Tunisia by 45.1% (Denguezli et al, 2016), Denmark by 22% (Thomsen, Nordestgaard, Vestbo, & Lange, 2013), Malaysia and Indonesia respectively at 21% and 27% (Salvi & Barnes, 2009).…”
Section: Introductionmentioning
confidence: 99%