1971
DOI: 10.1159/000230399
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The Influence of Gold on the Kinetics of Plaque-Forming Cells

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1978
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Cited by 12 publications
(7 citation statements)
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“…Percy et al,27 using their arbitrary normal/abnormal classification of lymphocyte transformation, showed an association between improvement in disease and improvement in lymphocyte response. In a similar manner on our arbitrary definition of a response to gold therapy there is a significant association between a normal con-A concentration at [15][16][17][18][19][20][21][22][23][24] weeks and a favourable response to gold therapy (X2 = 10-4, P = 0-01 with Yates's correction for small numbers). However, the numbers are small (4 out of 5 nonresponders outside the normal range after treatment) and the association did not hold for PHA and PWM.…”
Section: Discussionmentioning
confidence: 85%
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“…Percy et al,27 using their arbitrary normal/abnormal classification of lymphocyte transformation, showed an association between improvement in disease and improvement in lymphocyte response. In a similar manner on our arbitrary definition of a response to gold therapy there is a significant association between a normal con-A concentration at [15][16][17][18][19][20][21][22][23][24] weeks and a favourable response to gold therapy (X2 = 10-4, P = 0-01 with Yates's correction for small numbers). However, the numbers are small (4 out of 5 nonresponders outside the normal range after treatment) and the association did not hold for PHA and PWM.…”
Section: Discussionmentioning
confidence: 85%
“…The improvement over pretreatment values was significant for con-A and PWM when measured as area and for con-A when response at optimal concentration is considered. Thus, in this n=14 [15][16][17][18][19][20][21][22][23][24] group of patients there was an overall trend towards improvement of lymphocyte mitogen responsiveness during gold treatment. This contrasts with the suppressive effects of gold salts added to lymphocyte cultures in vitro.…”
Section: Discussionmentioning
confidence: 93%
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“…1963; Jessop et al 1973), an effect consistent with the inhibition of cell immigration observed with different dosing regimes. There are, however, reports indicating that concurrent injections of organic gold compounds and antigen resulted in immuno-enhancement that could be measured by direct and indirect plaque-forming cells and rosette-forming cells (Scheiffarth et al 1971;Measel 1975). Indomethacin in the doses used, fully effective in other experimental inflammatory reactions has been unable to modify the cell immigration at the site of challenge.…”
Section: Discussionmentioning
confidence: 98%