The influence of H<sub>2</sub>O<sub>2</sub> on the antibacterial activity of ZnO

Liu, Suiping; Lai, Yu-Ting; Zhao, Xu; Li, Ruicheng; Huang, Fei; Zheng, Zhuli; Ying, Muying

doi:10.1088/2053-1591/ab2506

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…When NPs enter microorganisms, they disrupt biological processes [51]. Furthermore, the surface attachment of NPs to bacterial cell surfaces causes them to become static [52]. Our findings in this study demonstrated that treatment with prepared 4NBZnO NPs significantly inhibited the growth of pathogenic bacteria.…”

Section: Discussionmentioning

confidence: 70%

Synthesis and characterization of 4‐nitro benzaldehyde with ZnO‐based nanoparticles for biomedical applications

Indumathi,

Kumaresan,

Suriyaprakash

et al. 2023

J Basic Microbiol

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Globally, cancer is the leading cause of death and morbidity, and skin cancer is the most common cancer diagnosis. Skin problems can be treated with nanoparticles (NPs), particularly with zinc oxide (ZnO) NPs, which have antioxidant, antibacterial, anti‐inflammatory, and anticancer properties. An antibacterial activity of zinc oxide nanoparticles prepared in the presence of 4‐nitrobenzaldehyde (4NB) was also tested in the present study. In addition, the influence of synthesized NPs on cell apoptosis, cell viability, mitochondrial membrane potential (MMP), endogenous reactive oxygen species (ROS) production, apoptosis, and cell adhesion was also examined. The synthesized 4‐nitro benzaldehyde with ZnO (4NBZnO) NPs were confirmed via characterization techniques. 4NBZnO NPs showed superior antibacterial properties against the pathogens tested in antibacterial investigations. As a result of dose‐based treatment with 4NBZnO NPs, cell viability, and MMP activity of melanoma cells (SK‐MEL‐3) cells were suppressed. A dose‐dependent accumulation of ROS was observed in cells exposed to 4NBZnO NPs. As a result of exposure to 4NBZnO NPs in a dose‐dependent manner, viable cells declined and apoptotic cells increased. This indicates that apoptotic cell death was higher. The cell adhesion test revealed that 4NBZnO NPs reduced cell adhesion and may promote apoptosis of cancer cells because of enhanced ROS levels.

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Section: Discussionmentioning

confidence: 70%

Synthesis and characterization of 4‐nitro benzaldehyde with ZnO‐based nanoparticles for biomedical applications

Indumathi,

Kumaresan,

Suriyaprakash

et al. 2023

J Basic Microbiol

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“…Production of ROS, particularly H 2 O 2 , has long been a prevailing theory of ZnO NP-mediated toxicity with multiple studies directly measuring ROS production by ZnO NPs ( Xu et al, 2013 ; Tiwari et al, 2018 ; Liu et al, 2019 ; Soltanian et al, 2021 ). The bigger question is the biological significance of this ROS production.…”

Section: Discussionmentioning

confidence: 99%

Zinc oxide nanoparticles mediate bacterial toxicity in Mueller-Hinton Broth via Zn2+

Caron,

Ali,

Delgado

et al. 2024

Front. Microbiol.

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As antibiotic resistance increases and antibiotic development dwindles, new antimicrobial agents are needed. Recent advances in nanoscale engineering have increased interest in metal oxide nanoparticles, particularly zinc oxide nanoparticles, as antimicrobial agents. Zinc oxide nanoparticles are promising due to their broad-spectrum antibacterial activity and low production cost. Despite many studies demonstrating the effectiveness of zinc oxide nanoparticles, the antibacterial mechanism is still unknown. Previous work has implicated the role of reactive oxygen species such as hydrogen peroxide, physical damage of the cell envelope, and/or release of toxic Zn2+ ions as possible mechanisms of action. To evaluate the role of these proposed methods, we assessed the susceptibility of S. aureus mutant strains, ΔkatA and ΔmprF, to zinc oxide nanoparticles of approximately 50 nm in size. These assays demonstrated that hydrogen peroxide and electrostatic interactions are not crucial for mediating zinc oxide nanoparticle toxicity. Instead, we found that Zn2+ accumulates in Mueller-Hinton Broth over time and that removal of Zn2+ through chelation reverses this toxicity. Furthermore, we found that the physical separation of zinc oxide nanoparticles and bacterial cells using a semi-permeable membrane still allows for growth inhibition. We concluded that soluble Zn2+ is the primary mechanism by which zinc oxide nanoparticles mediate toxicity in Mueller-Hinton Broth. Future work investigating how factors such as particle morphology (e.g., size, polarity, surface defects) and media contribute to Zn2+ dissolution could allow for the synthesis of zinc oxide nanoparticles that possess chemical and morphological properties best suited for antibacterial efficacy.

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“…As a metal-organic framework with a large specific surface area and excellent thermal stability, zeolite imidazole framework 67 (ZIF-67) showed great application potential because it can be synthesised in aqueous solution at room temperature. Liu et al 55 used PEI and ZIF-67 as a mixed sizing agent to build the composite interface and improve the interface strength of CF/PEEK composites (Fig. 6).…”

Section: Preparation Of Cf/peek Composites By Coating Cf With Mixed S...mentioning

confidence: 99%

Improving the interface of carbon‐fibre‐reinforced poly(ether‐ether‐ketone) composites with fibre surface coating: a review

Ren

Zhu

Zhang³

et al. 2022

Polymer International

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As a high‐performance thermoplastic polymer, poly(ether‐ether‐ketone) (PEEK) has excellent thermal stability and mechanical properties; it is widely used in the aerospace field. However, PEEK has high viscosity, high processing temperature and poor fluidity in the molten state. In preparing carbon fibre (CF)/PEEK composites, poor impregnation performance will occur, resulting in high porosity and poor mechanical properties of the CF/PEEK composites. This mini‐review focuses on improving the interface of the CF/PEEK composite by coating the CF surface and introduces the preparation of CF/PEEK composites by coating CF with a resin‐based sizing agent, a mixed sizing agent and nanoparticles. Meanwhile, the properties of CF/PEEK composites prepared by different coating methods are compared. © 2022 Society of Industrial Chemistry.

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The influence of H₂O₂ on the antibacterial activity of ZnO

Cited by 10 publications

References 20 publications

Synthesis and characterization of 4‐nitro benzaldehyde with ZnO‐based nanoparticles for biomedical applications

Synthesis and characterization of 4‐nitro benzaldehyde with ZnO‐based nanoparticles for biomedical applications

Zinc oxide nanoparticles mediate bacterial toxicity in Mueller-Hinton Broth via Zn2+

Improving the interface of carbon‐fibre‐reinforced poly(ether‐ether‐ketone) composites with fibre surface coating: a review

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The influence of H2O2 on the antibacterial activity of ZnO

Cited by 10 publications

References 20 publications

Synthesis and characterization of 4‐nitro benzaldehyde with ZnO‐based nanoparticles for biomedical applications

Synthesis and characterization of 4‐nitro benzaldehyde with ZnO‐based nanoparticles for biomedical applications

Zinc oxide nanoparticles mediate bacterial toxicity in Mueller-Hinton Broth via Zn2+

Improving the interface of carbon‐fibre‐reinforced poly(ether‐ether‐ketone) composites with fibre surface coating: a review

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The influence of H₂O₂ on the antibacterial activity of ZnO