The influence of halothane, isoflurane and sevoflurane on rocuronium infusion in children

Wołoszczuk-Gębicka, Bogumiła; Lapczynski, T.; Wierzejski, W.

doi:10.1034/j.1399-6576.2001.450112.x

Cited by 26 publications

(31 citation statements)

References 27 publications

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“…Halogenated anaesthetics have also a neuromuscular blocking action [82], by which sevoflurane can augment the action of non-depolarizing neuromuscular blocking agents. Its rapid elimination limits the risk of post-operative complication.…”

Section: Malignant Hyperthermiamentioning

confidence: 99%

Sevoflurane inside and outside the operating room

Michel

Constantin

2009

Expert Opinion on Pharmacotherapy

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Background: Sevoflurane is often presented as a near-perfect anaesthetic. After 10 years in the operating room, new uses are emerging outside. Objective: To remind readers of the principal characteristics of sevoflurane, to affirm its usefulness for day-case anaesthesia and to consider the recent new uses. Methods: The discussion of the physical properties, pharmacokinetics, metabolism, mechanisms of action and clinical effects is based on classic, essential papers. Recent literature concerning emerging utilizations of sevoflurane was analysed. Results: Sevoflurane presents many benefits with minimum inconvenience. It allows rapid inhalation induction, maintenance and rapid recovery. It has little toxicity and its haemodynamic and respiratory depressive effects are moderate and well tolerated. It is already widely use for sedation for magnetic resonance imaging in children. Its use in paediatric or adult intensive care could improve the management of pain and sedation.

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Section: Malignant Hyperthermiamentioning

confidence: 99%

Sevoflurane inside and outside the operating room

Michel

Constantin

2009

Expert Opinion on Pharmacotherapy

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“…We found similar results by comparing both enflurne and sevoflurane in the present study. In parallel with our study, the rocuronium infusion rate required to maintain stable 90%-99% T1 depression was reduced by approximately 20% with halothane and isoflurane anesthesia, and by 50% with sevoflurane anesthesia, when compared with fentanyl-nitrous oxide anesthesia [25].…”

Section: Resultsmentioning

confidence: 88%

Comparison of the effects of neuroleptanesthesia and enflurane or sevoflurane anesthesia on neuromuscular blockade by rocuronium

Güngör

Bozkırlı

Çelebi

et al. 2003

Journal of Anesthesia

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Materials and methodsForty-five unpremedicated ASA class I or II patients scheduled to undergo either orthopedic or ear, nose, and throat surgery under general anesthesia with an anticipated duration of approximately 1.5-3 h were enrolled in this study after approval of the hospital ethics committee and written informed consent from the patients had been obtained. All patients were free from neuromuscular, endocrine, liver, or renal diseases and were not receiving drugs known to interact with neuromuscular blocking agents. They required muscle relaxation only for endotracheal intubation.An intravenous infusion of 0.9% sodium chloride solution was given initially via the basilic vein on one of the arms, while the other arm was kept for monitoring neuromuscular block. The heart rate (HR), mean arterial pressure (MAP), peripheral oxygen saturation (SpO 2 ) (Odam Physiogard SM 785, Wissenbourg, France), and end-tidal concentrations of CO 2 and volatile anesthetics (Artema MM 256, Sundbyberg, Sweden) were monitored. Each patient was allocated to one of three groups: enflurane (group E, n ϭ 15), sevoflurane (group S, n ϭ 15), and neuroleptanesthesia (group NA, n ϭ 15). The induction of anesthesia was performed with i.v. fentanyl 2 µg · kg Ϫ1 and thiopentone 5-7 mg·kg Ϫ1 , followed by a volatile anesthetic, either enflurane or sevoflurane, with assisted ventilation by mask in groups E and S, respectively. The volatile anesthetics (enflurane or sevoflurane) were administered in 66%/33% : nitrous oxide/oxygen at the endtidal concentration corresponding to 1 minimum alveolar concentration (MAC) in the present study. One MAC of enflurane and sevoflurane was assumed to be 0.57% and 0.66% in approximately 66% nitrous oxide, respectively [13]. In group NA, anesthesia was induced with i.v. droperidol 0.2 mg · kg Ϫ1 , fentanyl 5 µg · kg Ϫ1 , and thiopentone 1-2 mg · kg Ϫ1 during inhalation of 66%/33% : N 2 O/O 2 . Stable end-tidal anesthetic concen-

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“…This new group of pediatric-trained anesthesiologists also sought training in critical care. The rise of these triple-trained anesthesiologists, routine use of pulse oximetry and newer anesthetic agents such as rocuronium, desflurane and sevoflurane, changed the practice of providing anesthesia for children for surgical procedures [34,35,36,37]. Indeed, as the practice of pediatric anesthesia evolved, with newer agents such as sevoflurane, as opposed halothane, the anxiety level of anesthesia providers during critical periods of anesthesia, such as the anesthetic induction of an infant or young child, was reduced [3,37,38].…”

Section: Historymentioning

confidence: 99%

“…Indeed, with gradual titration of an anesthetic that was less irritating to the peripheral airway, such as halothane, and, in present day, sevoflurane, anesthesia could be more safely provided to even extremely premature neonates [37]. Moreover, as we gained comfort with anesthetic induction in these young infants and children, we began to add “cures” for preoperative anxiety, which included the use of a premedication with midazolam or the parental presence in the operating room during anesthetic induction [36,39,40].…”

Section: Historymentioning

confidence: 99%

Anesthesia and the Developing Brain: Relevance to the Pediatric Cardiac Surgery

2014

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Anesthetic neurotoxicity has been a hot topic in anesthesia for the past decade. It is of special interest to pediatric anesthesiologists. A subgroup of children potentially at greater risk for anesthetic neurotoxicity, based on a prolonged anesthetic exposure early in development, are those children receiving anesthesia for surgical repair of congenital heart disease. These children have a known risk of neurologic deficit after cardiopulmonary bypass for surgical repair of congenital heart disease. Yet, the type of anesthesia used has not been considered as a potential etiology for their neurologic deficits. These children not only receive prolonged anesthetic exposure during surgical repair, but also receive repeated anesthetic exposures during a critical period of brain development. Their propensity to abnormal brain development, as a result of congenital heart disease, may modify their risk of anesthetic neurotoxicity. This review article provides an overview of anesthetic neurotoxicity from the perspective of a pediatric cardiac anesthesiologist and provides insight into basic science and clinical investigations as it relates to this unique group of children who have been studied over several decades for their risk of neurologic injury.

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The influence of halothane, isoflurane and sevoflurane on rocuronium infusion in children

Cited by 26 publications

References 27 publications

Sevoflurane inside and outside the operating room

Sevoflurane inside and outside the operating room

Comparison of the effects of neuroleptanesthesia and enflurane or sevoflurane anesthesia on neuromuscular blockade by rocuronium

Anesthesia and the Developing Brain: Relevance to the Pediatric Cardiac Surgery

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