The Influence of Halothane on Fentanyl Pharmacokinetics

Borel, J. D.; Bentley, John B.; Nenad, Robert E.; Gillespie, T. J.

doi:10.1097/00000542-198209001-00239

Cited by 9 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both Mather and colleagues [17] and Behne and colleagues [18] have also shown in sheep an absence of any significant effect of volatile anaesthetic agents on the clearance of lignocaine and midazolam, although this is in contrast to the findings of Bentley, Glass and Gandolfi in man [19]. In addition, there have been reports of significant decreases in systemic clearance of fentanyl, systemic and intrinsic clearance of propranolol and systemic clearance of verapamil during halothane anaesthesia in dogs [20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Studies on Morphine Disposition: Influence of General Anaesthesia on Plasma Concentrations of Morphine and Its Metabolites †

Sear

Hand

Moore

et al. 1989

British Journal of Anaesthesia

View full text Add to dashboard Cite

The kinetics of morphine were studied during balanced anaesthesia in 10 patients undergoing lower abdominal or body surface surgery, and compared with those obtained in nine awake patients receiving morphine i.v. for the relief of chronic non-cancer pain. All patients received morphine sulfphate pentahydrate 10 mg i.v. over 30 s. Venous blood samples were collected for up to 180 min, and plasma concentrations of morphine, morphine-3-glucuronide (M3G), and morphine-6-glucuronide (M6G) assayed by a differential radioimmunoassay technique. There were no differences between groups with respect to the elimination half-life (awake group: 207 min; anaesthetized group: 153 min), volume of distribution at steady state (awake: 147 litre; anaesthetized: 128 litre), or clearance (awake: 587 ml min-1; anaesthetized: 766 ml min-1). Peak concentrations of M3G were similar in the two groups, but the peak concentration of M6G was greater in the anaesthetized patients. The AUC for M3G and M6G (0-180 min) also were greater in the anaesthetized patients, presumably as a result of decreases in renal blood flow and glomerular filtration rate during halothane anaesthesia.

show abstract

Section: Discussionmentioning

confidence: 99%

Studies on Morphine Disposition: Influence of General Anaesthesia on Plasma Concentrations of Morphine and Its Metabolites †

Sear

Hand

Moore

et al. 1989

British Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

“…It is increasingly clear that volatile anaesthetic agents influence the disposition of several drugs including fentanyl [20] and verapamil [21] in the dog, and lignocaine in man [22]. Moreover, different volatile anaesthetic agents may have different effects [23].…”

Section: Table IV Relationship Between Clearance and Sex Of The Patimentioning

confidence: 99%

Effect of Age, Sex and Anaesthetic Technique on the Pharmacokinetics of Atracurium

Parker

Hunter

Snowdon

1992

British Journal of Anaesthesia

View full text Add to dashboard Cite

We have defined the pharmacokinetics of atracurium besylate 0.25 mg kg-1 in 41 patients anaesthetized with 0.9% isoflurane end-tidal, 0.5% halothane end-tidal or midazolam 3-10 mg as a supplement to 66% nitrous oxide in oxygen. The pharmacokinetic profile was affected by age, sex and anaesthetic technique. Advancing age was associated with a reduced clearance and a longer elimination half-time; clearance was greater and elimination half-time was shorter in males than in females. Clearance was also greater in patients anaesthetized with isoflurane than with the two other techniques. Age, sex and anaesthetic technique did not significantly affect the volume of distribution.

show abstract

“…In dogs, the pharmacokinetic variables of alfentanil have been reported for analgesic (50 |xg/kg) and anesthetic (300 fxg/kg) doses. 3 In that study,3 the plasma concentration-time data were best described by use of a triexponential function, and difference in pharmacokinetic behavior was not found between the 2 doses. At the low dose, volume of the central compartment was 295 ± 32 ml/kg, volume of distribution was 4,600 ± 1,100 ml/kg, body clearance was 568 ± 30 ml/min, and elimination half-life was 168 ± 5 minutes.…”

Section: Discussionmentioning

confidence: 90%

“…In dogs, alfentanil has been shown to have dose-independent pharmacokinetic variables for doses ranging between 50 and 300 |xg/kg. 3 In all animals, administration of alfentanil caused profound sedation and apnea. Despite being given a higher dose, sheep recovered rapidly, with spontaneous respiration returning during the infusion, and chewing was evident 5 minutes after termination of the infusion.…”

Section: Discussionmentioning

confidence: 93%

Comparative study of the pharmacokinetics of alfentanil in rabbits, sheep, and dogs

Ilkiw,

Benthuysen,

McNeal

1991

ajvr

View full text Add to dashboard Cite

SUMMARY The central arterial pharmacokinetics of alfentanil, a short-acting opioid agonist, were studied in rabbits, sheep, and dogs after short-duration infusion of the drug. Alfentanil was infused until a set end point (high-amplitude, slow-wave activity on the eeg) was reached. This required a larger alfentanil dose and a higher alfentanil arterial concentration in sheep, compared with rabbits and dogs. The plasma concentration-time data for each animal were fitted, using nonlinear regression, and in all animals, were best described by use of a triexponential function. In this study, differences in the disposition kinetics of alfentanil among the 3 species were found for only distribution clearance and initial distribution halflife. In dogs, compared with rabbits and sheep, the first distribution half-life was longer, probably because of pronounced drug-induced bradycardia (mean ± SD, 48 ± 21 beats/min). Distribution clearance was faster in sheep, compared with dogs, also probably because of better blood flow in sheep. Elimination half-life was similar in all species (rabbits, 62.4 ± 11.3 minutes; sheep, 65.1 ± 27.1 minutes; dogs, 58.3 ± 10.3 minutes). This rapid half-life resulted from a small steady-state volume of distribution (rabbits, 908.3 ± 269.0 ml/kg; sheep, 720.0 ± 306.7 ml/ kg; dogs, 597.7 ± 290.2 ml/kg) and rapid systemic clearance (rabbits, 19.4 ± 5.3 ml/min/kg; sheep, 13.3 ± 3.0 ml/min/kg; dogs, 18.7 ± 7.5 ml/min/kg). On the basis of these pharmacokinetic variables, alfentanil should have short duration of action in rabbits, sheep, and dogs. This may be beneficial in veterinary practice where rapid recovery would be expected after bolus administration for short procedures or after infusion for longer procedures.

show abstract

The Influence of Halothane on Fentanyl Pharmacokinetics

Cited by 9 publications

References 0 publications

Studies on Morphine Disposition: Influence of General Anaesthesia on Plasma Concentrations of Morphine and Its Metabolites †

Studies on Morphine Disposition: Influence of General Anaesthesia on Plasma Concentrations of Morphine and Its Metabolites †

Effect of Age, Sex and Anaesthetic Technique on the Pharmacokinetics of Atracurium

Comparative study of the pharmacokinetics of alfentanil in rabbits, sheep, and dogs

Contact Info

Product

Resources

About