The Influence of Helicobacter pylori Eradication on Leptin, Soluble CD40 Ligand, Oxidative Stress and Body Composition in Patients with Peptic Ulcer Disease

Kebapçılar, Levent; Sarı, İ̇smail; Renkal, Ali Haydar; Alacacıoğlu, Ahmet; Yüksel, Arif; İlhan, Enver; Alkan, Bülent; Yüksel, Diydem; Kozacı, Didem; Günay, Necati

doi:10.2169/internalmedicine.48.2562

Cited by 25 publications

(7 citation statements)

References 30 publications

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“…In contrast, significantly higher CVLU antioxidant capacities were identified with increasing bioburden, possibly reflecting an effective adaptive response to bacterial challenge and chronic inflammation in CVLUs. Similar findings have been reported in sepsis and peptic ulceration, where antioxidant capacities only decline on eradication of infection . However, DFU antioxidant adaptations to increasing bioburden may be effectively “overwhelmed” by the enhanced oxidative stress exposure, reflecting the higher antioxidant capacities in DFUs overall.…”

Section: Discussionsupporting

confidence: 78%

“…Similar findings have been reported in sepsis and peptic ulceration, where antioxidant capacities only decline on eradication of infection. 39,40 However, DFU antioxidant adaptations to increasing bioburden may be effectively "overwhelmed" by the enhanced oxidative stress exposure, reflecting the higher antioxidant capacities in DFUs overall.…”

Section: Ulcer Responses To Bacterial Infectionmentioning

confidence: 99%

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Contrasting host immuno‐inflammatory responses to bacterial challenge within venous and diabetic ulcers

McInnes¹,

Cullen²,

Hill

et al. 2013

Wound Repair Regeneration

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Within chronic wounds, the relationship between the clinical diagnosis of infection and bacterial/immuno-inflammatory responses is imprecise. This study prospectively examined the interrelationship between clinical, microbiological, and proinflammatory biomarker levels between chronic venous leg ulcers (CVLUs) and diabetic foot ulcers (DFUs). Wound swabs and fluids were collected from CVLUs (n = 18) and DFUs (n = 15) and diagnosed clinically as noninfected or infected; and qualitative/quantitative microbiology was performed. CVLU and DFU fluids were also analyzed for cytokine, growth factor, receptor, proteinase/proteinase inhibitor; and oxidative stress biomarker (protein carbonyl, malondialdehyde, and antioxidant capacity) levels. While no correlations existed between clinical diagnosis, microbiology, or biomarker profiles, increasing bacterial bioburden (≥10(7) colony-forming unit/mL) was associated with significant alterations in cytokine, growth factor, and receptor levels. These responses contrasted between ulcer type, with elevated and decreased cytokine, growth factor, and receptor levels in CVLUs and DFUs with increasing bioburden, respectively. Despite proteinase biomarkers exhibiting few differences between CVLUs and DFUs, significant elevations in antioxidant capacities correlated with increased bioburden in CVLU fluids, but not in DFUs. Furthermore, oxidative stress biomarker levels were significantly elevated in all DFU fluids compared with CVLUs. This study provides further insight into the contrasting disease-specific host responses to bacterial challenge within infected CVLUs and DFUs.

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Section: Discussionsupporting

confidence: 78%

Section: Ulcer Responses To Bacterial Infectionmentioning

confidence: 99%

Contrasting host immuno‐inflammatory responses to bacterial challenge within venous and diabetic ulcers

McInnes¹,

Cullen²,

Hill

et al. 2013

Wound Repair Regeneration

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“…Another study found that lean body mass increased significantly without any increase in body fat after H. pylori eradication, which also supports our hypothesis. 20 Further studies should investigate whether H. pylori eradication improves both appendicular muscle mass and strength.…”

Section: Discussionmentioning

confidence: 99%

Elderly women who received Helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass

Baeg

Choi

et al. 2015

CIA

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BackgroundSarcopenia is associated with adverse outcomes such as physical disability, poorer quality of life, and death. Helicobacter pylori (HP) eradication increases ghrelin secretion, which may be a possible treatment for sarcopenia. We investigated whether HP eradication reduces the risk of low muscle mass (LMM), which is an integral component of sarcopenia.Materials and methodsHealthy, asymptomatic women aged ≥60 years who participated in a health screening program were enrolled. Subjects with a history of HP eradication were compared with those who were HP IgG+, but had not received HP-eradicating therapy. Body composition was measured by multifrequency bioelectrical impedance analysis. LMM was defined as body muscle mass 2 standard deviations below the mean muscle mass of healthy women aged 20–39 years from the same program. Multivariable analysis was used to identify sarcopenia risk factors.ResultsThree hundred seventy-two women had received HP eradication, while 689 HP IgG+ women had not. The prevalence of LMM was significantly lower in those who received HP eradication (13.7% vs 21.6%, P=0.002). Multivariable analysis identified risk factors for LMM as age, white blood cell count, serum total protein concentration, and the metabolic syndrome. HP eradication (odds ratio: 0.632, 95% confidence interval: 0.440–0.824, P=0.013) was a significant preventive factor, and exercise (odds ratio: 0.710, 95% confidence interval: 0.504–1.002, P=0.051) had a preventive tendency.ConclusionHP eradication might reduce LMM risk. This finding should be confirmed in prospective longitudinal studies to determine the long-term effects of HP eradication on sarcopenia.

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“…An intervention study carried out in H. pylori positive children with previous growth retardation and low ghrelin levels, showed restoration of normal ghrelin levels and increased weight gain upon H. pylori eradication (61). By contrast, other studies reported significant weight loss, decrease in fat mass percentage and increase in fat-free mass after H. pylori eradication treatment (62,63) or no effect on body weight (64) in adults. These contradictory results can be due to the different populations analyzed including different age groups.…”

Section: H Pylori Infection and Metabolic Diseasesmentioning

confidence: 99%

Gut Microbiota: The Missing Link Between Helicobacter pylori Infection and Metabolic Disorders?

et al. 2021

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Helicobacter pylori (H. pylori) is a gram-negative bacterium that infects approximately 4.4 billion individuals worldwide. Although the majority of infected individuals remain asymptomatic, this bacterium colonizes the gastric mucosa causing the development of various clinical conditions as peptic ulcers, chronic gastritis and gastric adenocarcinomas and mucosa-associated lymphoid tissue lymphomas, but complications are not limited to gastric ones. Extradigestive pathologies, including metabolic disturbances such as diabetes, obesity and nonalcoholic fatty liver disease, have also been associated with H. pylori infection. However, the underlying mechanisms connecting H. pylori with extragastric metabolic diseases needs to be clarified. Notably, the latest studies on the topic have confirmed that H. pylori infection modulates gut microbiota in humans. Damage in the gut bacterial community (dysbiosis) has been widely related to metabolic dysregulation by affecting adiposity, host energy balance, carbohydrate metabolism, and hormonal modulation, among others. Taking into account that Type 2 diabetic patients are more prone to be H. pylori positive, gut microbiota emerges as putative key factor responsible for this interaction. In this regard, the therapy of choice for H. pylori eradication, based on proton pump inhibitor combined with two or more antibiotics, also alters gut microbiota composition, but consequences on metabolic health of the patients has been scarcely explored. Recent studies from our group showed that, despite decreasing gut bacterial diversity, conventional H. pylori eradication therapy is related to positive changes in glucose and lipid profiles. The mechanistic insights explaining these effects should also be addressed in future research. This review will deal with the role of gut microbiota as the linking factor between H. pylori infection and metabolic diseases, and discussed the impact that gut bacterial modulation by H. pylori eradication treatment can also have in host’s metabolism. For this purpose, new evidence from the latest human studies published in more recent years will be analyzed.

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The Influence of Helicobacter pylori Eradication on Leptin, Soluble CD40 Ligand, Oxidative Stress and Body Composition in Patients with Peptic Ulcer Disease

Abstract: Objective

Cited by 25 publications

References 30 publications

Contrasting host immuno‐inflammatory responses to bacterial challenge within venous and diabetic ulcers

Contrasting host immuno‐inflammatory responses to bacterial challenge within venous and diabetic ulcers

Elderly women who received Helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass

Gut Microbiota: The Missing Link Between Helicobacter pylori Infection and Metabolic Disorders?

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