The influence of hemoglobinopathies on reproduction

Hendrickse, J. P. De V.; Watson-Williams, E.

doi:10.1016/0002-9378(66)90406-6

Cited by 26 publications

(19 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…& Clement, 1957;Roberts & Hilburg, 1958). Infarctive sickle cell crises are more frequent and more severe during pregnancy than in the non-pregnant state (Hendrickse & Watson-Williams, 1966;Akinla, 1972). One can therefore understand the occurrence of avascular necrosis or osteomyelitis in the three cases here reported.…”

Section: Discussionmentioning

confidence: 99%

“…This is bebecause the bone changes of marrow hyperplasia, thrombosis, infarction, osteoporosis and reactive osteosclerosis seen in sickle cell disease may lead to avascu.lar necrosis and so predispose to the development of superimposed bone infections (Silver, Simon , 1957;Roberts & Hilburg, 1958). Infarctive sickle cell crises are more frequent and more severe during pregnancy than in the non-pregnant state (Hendrickse & Watson-Williams, 1966;Akinla, 1972). One can therefore understand the occurrence of avascular necrosis or osteomyelitis in the three cases here reported.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence, though low, is certainly increasing. This is because young girls with a chronic haemolytic anaemia who in the past readily succumbed to intercurrent disease and malnutrition are now, with improved medical facilities, surviving to child-bearing age (Hendrickse & Watson-Williams, 1966).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pregnancy and the skeletal complications of sickle cell disease

Akinla

1973

Postgraduate Medical Journal

View full text Add to dashboard Cite

Summary An account is given of three patients with the skeletal complications of sickle cell disease in association with pregnancy. Avascular necrosis of bone and acute osteomyelitis are the usual forms of these complications. The associated high perinatal mortality is probably due to the constant hypoxia to which the foetus is exposed during both pregnancy and labour.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pregnancy and the skeletal complications of sickle cell disease

Akinla

1973

Postgraduate Medical Journal

View full text Add to dashboard Cite

show abstract

“…We now turn to the question of the fertility of these carriers under such conditions. Data about this problem are scanty, being exclusively restricted to the com parison of the obstetrical histories of women living in the United States [1,2,4,5,8,9,[12][13][14]24], The present note reports the results of a pilot S alzano/da Rocha/Simôes study designed to verify the possibility of detecting fertility differences with sample sizes of the same order of magnitude as those investigated in malari ous regions.…”

Section: Introductionmentioning

confidence: 99%

Fertility of Abnormal Hemoglobin Carriers in Porto Alegre, Brazil

1973

View full text Add to dashboard Cite

No significant differences were observed on the average number of pregnancies and livebirths, as well as on the frequencies of spontaneous abortions, stillbirths, premature children and those dying before the age of reproduction when the reproductive performances of 123 couples having at least one abnormal hemoglobin carrier were compared with the same number of appropriately chosen controls. The number of sibs of these carriers and of those with normal hemoglobin only did not differ significantly either. These and viability data reported elsewhere indicate essentially similar fitnesses for the individuals compared, who live in the nonmalarious environment of Porto Alegre. The fate of the Hb^s and Hb^c genes seems to be their gradual disappearance from this and other populations of the New World.

show abstract

“…This condition can progress rapidly to a fatal conclusion unless early diagnosis and treatment is initiated (Rywlin, Black, and Werner, 1963;Hendrickse and Watson Williams, 1966). In the case reported the diagnosis of pulmonary fat embolism was suspected on clinical and haematological grounds.…”

mentioning

confidence: 99%

Fat embolism in sickle cell disease

Hutchinson¹,

Merrick²,

White³

1973

J Clin Pathol

View full text Add to dashboard Cite

Fat embolism is a known complication of marrow infarction in patients with sickle cell disease (Hb S/S and Hb S/C) disease. It should be considered in sickle cell crisis when there is deterioration in respiratory function, a fall in arterial PO2, a normoblastaemia, and a thrombocytopenia in the peripheral blood. We now report a patient in whom the diagnosis was confirmed in life by identifying fat in the sputum, demonstrating disseminated intravascular coagulation, and using a double isotope technique to distinguish recent from old marrow infarction. Use of these features enabled an early diagnosis to be made which led to a successful outcome in a potentially fatal condition.

show abstract

The influence of hemoglobinopathies on reproduction

Cited by 26 publications

References 54 publications

Pregnancy and the skeletal complications of sickle cell disease

Pregnancy and the skeletal complications of sickle cell disease

Fertility of Abnormal Hemoglobin Carriers in Porto Alegre, Brazil

Fat embolism in sickle cell disease

Contact Info

Product

Resources

About