The influence of hepatitis B virus infection in pregnant women

Kang, Lina; Pian, Yaya; Gao, Zhenxiang; Hu, Jihong; Nie, Jun

doi:10.1080/07399332.2021.1883024

Cited by 3 publications

(4 citation statements)

References 23 publications

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“… 19 However, it was higher than that in Shaanxi (7.07%), 10 Guangdong (7.69%), 18 and Zhejiang (5.88%). 23 Similar to other reports, the prevalence of HBV infection was significantly lower in Liaoning (3.08%), 24 Tianjin (3.77%), 25 Shanxi (4.90%), 26 Xinjiang (4.43%), 26 Sichuan (4.24%), 27 and Yunnan (3.28%). 28 The prevalence rate of HBV infection differed among pregnant women in the provinces of China and at different periods.…”

Section: Discussionsupporting

confidence: 87%

Prevalence of hepatitis B virus infection among pregnant women in the mountainous regions of southern China: A retrospective single‐center study

Deng

Lin

Guo

et al. 2023

Clinical Laboratory Analysis

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Background Hepatitis B virus (HBV) infection remains a major public health issue worldwide. Moreover, its prevalence varies significantly in different geographic areas of China. The current study aimed to assess the prevalence of HBV infection among Hakka pregnant women in Meizhou, a remote mountainous region in southern China. Methods This research was performed between January 2015 and December 2020. In total, 16,727 pregnant women receiving antenatal care at Meizhou People's Hospital were included in the analysis. All pregnant women were screened for serum HBV markers. Results The prevalence rates of hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody positivity among the participants were 11.74% ( n = 1964) and 48.00% ( n = 8029), respectively. The overall prevalence rates of susceptibility to infection, HBV immunity, previous/occult infection, inactive HBsAg carrier, and active infection were 36.16%, 33.61%, 16.94%, 8.11%, and 2.30%, respectively. According to age distribution, the prevalence rate of HBsAg positivity elevated concomitantly with increasing age ( p < 0.001). From 2015 to 2020, the prevalence rate of HBsAg positivity decreased from 14.50% to 8.19% and that of hepatitis B pre‐core antigen positivity from 4.42% to 2.31%. In addition, pregnant women with HBsAg‐positive status were more likely to present with gestational diabetes, thrombocytopenia, and anemia than those with HBsAg‐negative status. Conclusion The HBV infection rate remains high among pregnant women in the indigenous Hakka population in southern China. To prevent vertical transmission, cautious surveillance of maternal HBV infection status should be considered in Hakka pregnant women in Meizhou.

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Section: Discussionsupporting

confidence: 87%

Prevalence of hepatitis B virus infection among pregnant women in the mountainous regions of southern China: A retrospective single‐center study

Deng

Lin

Guo

et al. 2023

Clinical Laboratory Analysis

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“…Based on this finding, we speculate that the maternal‐fetus interface of HBV‐PW prefers to maintain successful pregnancy to ensure fetus implantation even though chronic HBV infection may cause potential harm. This viewpoint might be supported by previous clinical RCT research demonstrating comparable incidence of miscarriage between HC‐PW and HBV‐PW 36 …”

Section: Discussionsupporting

confidence: 59%

“…This viewpoint might be supported by previous clinical RCT research demonstrating comparable incidence of miscarriage between HC-PW and HBV-PW. 36 One observation that deserves special attention in our study is the downregulation of PD1 in decidual T cells of HBV-PW; generally, PD1 is considered a hallmark of T cell exhaustion and to be tightly linked with reduced cytokine production, particularly in the context of chronic viral infections; however, the decreased production of IFN-γ derived from decidual CD8 + T cells is not consistent with this notion. Actually, PD1 is not an exhaustion-specific molecule.…”

Section: Discussionmentioning

confidence: 70%

Impaired CD8⁺ T cells in term pregnancy decidua with chronic hepatitis B virus infection

Liu

Lou

et al. 2022

American J Rep Immunol

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Problem Hepatitis B virus (HBV) infection is more likely to develop a state of chronicity in early life, particularly mother‐to‐child transmission (MTCT) of HBV in the fetus during pregnancy. Till now, little is known about the impact of chronic HBV infection on the immune status of the maternal‐fetus interface, and the immune profile of placental lymphocytes in MTCT of HBV is poorly understood. Method of Study Thirteen term pregnant women with chronic HBV infection (HBV‐PW) and thirteen normal pregnant women as healthy control (HC‐PW) were enrolled. The profile of placental immune cells and paired peripheral blood were analyzed by flow cytometry and immunohistochemistry. Results Compared with HC‐PW, the frequency of CD8+ T cells from the term placenta of HBV‐PW was significantly reduced. These cells showed decreased expression of activation molecules CD69 and HLA‐DR; thus, decidual CD8+ T cells from HBV‐PW demonstrated hypofunctional signature as evidenced by significantly reduced production of IFN‐γ, as well as compromised ability of degranulation and proliferation. Conclusions These findings supported that hypoactivated decidual CD8+ T cells might possess compromised ability in chronically HBV‐infected term pregnant women. Our study provides robust evidence for the necessity and importance of antiviral intervention in HBV‐PW to prevent MTCT of HBV.

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“…In this population-based cross-sectional study of nearly 90 million pregnant women in mainland China, the total prevalence of HBsAg was 6.17% (95%CI: 6.16-6.18%) between 2015 and 2020. Most previous studies reported province or regional prevalence of HBV infection in China, such as Tianjin (3.8%) [29] , Zhejiang (5.9%) [30] and Taiwan (12.4%) [31] . At national level, there were four national epidemiological surveys on investigating HBV infection in the general population in China, which was conducted in 1979 [22] , 1992 (including people aged 1-59 years) [32] , 2006 (including people aged 1-59 years) [ 33 , 34 ], and 2014 (including people aged 1-29 years) [9] , respectively.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B virus infection among 90 million pregnant women in 2853 Chinese counties, 2015-2020: a national observational study

Liu

Wang

et al. 2021

The Lancet Regional Health - Western Pacific

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Background: China has the largest disease burden of hepatitis B virus (HBV) infection and is considered as a major contributor to the global elimination of hepatitis B by 2030. However, the national prevalence of HBV infection among Chinese pregnant women was not reported yet. We evaluated the national and regional prevalence of HBV infection among pregnant women in China between 2015-2020, aiming to provide the latest baseline data. Methods: We assessed the prevalence of HBV infection from data gathered through a nationwide crosssectional study of Chinese pregnant women. Data were obtained from the National Integrated Prevention of Mother-to-Child Transmission of HIV, Syphilis and Hepatitis B Programme (iPMTCT Programme) in China, which covered all the 2856 counties from 31 provinces from 2015 to 2020. HBV infection was defined as being tested seropositive for hepatitis B surface antigen (HBsAg). Findings: A total of 90.87 million pregnant women in mainland China were testing for HBV between 2015 and 2020, with 5.60 million (6.17%, 95%CI: 6.16-6.18%) tested positive for HBsAg. From 2015 to 2020, the prevalence of HBV infection among pregnant women declined by 25.44%, from 7.30% in 2015 to 5.44% in 2020 (p for trend < 0.001), with an estimated annual percentage change (EAPC) of -5.27% (95% CI: -3.19% to -7.32%). Compared with the prevalence in 2015, reginal disparities in eastern, central, and western China were narrowed. Declines were also observed at provincial level and county level. HBV prevalence declined in most provinces (90.3%, 28/31) and counties (76.96%, 2198/2856) from 2015 to 2020. However, disparities still exist. Interpretation: HBV prevalence in pregnant women in China was intermediate endemic and declined continuously from 2015 to 2020. The decline has been widespread across regions, but disparities remain. Regions with relatively higher disease burden on HBV infection should receive most attention in achieving the 2030 elimination goals.

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The influence of hepatitis B virus infection in pregnant women

Cited by 3 publications

References 23 publications

Prevalence of hepatitis B virus infection among pregnant women in the mountainous regions of southern China: A retrospective single‐center study

Prevalence of hepatitis B virus infection among pregnant women in the mountainous regions of southern China: A retrospective single‐center study

Impaired CD8⁺ T cells in term pregnancy decidua with chronic hepatitis B virus infection

Hepatitis B virus infection among 90 million pregnant women in 2853 Chinese counties, 2015-2020: a national observational study

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The influence of hepatitis B virus infection in pregnant women

Cited by 3 publications

References 23 publications

Prevalence of hepatitis B virus infection among pregnant women in the mountainous regions of southern China: A retrospective single‐center study

Prevalence of hepatitis B virus infection among pregnant women in the mountainous regions of southern China: A retrospective single‐center study

Impaired CD8+ T cells in term pregnancy decidua with chronic hepatitis B virus infection

Hepatitis B virus infection among 90 million pregnant women in 2853 Chinese counties, 2015-2020: a national observational study

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Impaired CD8⁺ T cells in term pregnancy decidua with chronic hepatitis B virus infection