The influence of high-intensity compared with moderate-intensity exercise training on cardiorespiratory fitness and body composition in colorectal cancer survivors: a randomised controlled trial

Devin, James L.; Sax, Andrew T.; Hughes, Gareth I.; Jenkins, David G.; Aitken, Joanne F.; Chambers, Suzanne K.; Dunn, Jeff; Bolam, Kate A.; Skinner, Tina L.

doi:10.1007/s11764-015-0490-7

Cited by 99 publications

(111 citation statements)

References 57 publications

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“…Full details of participant recruitment have been reported elsewhere (Devin et al . ). The present study was approved by the Human Research Ethics Committee of The University of Queensland and informed consent was obtained from all participants.…”

Section: Methodsmentioning

confidence: 97%

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Acute high intensity interval exercise reduces colon cancer cell growth

Devin

Hill

Mourtzakis

et al. 2019

The Journal of Physiology

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105

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Key points Physical activity is associated with reduced mortality rates for survivors of colorectal cancer. Acute high intensity interval exercise (HIIE) reduced colon cancer cell number in vitro and promoted increases in inflammatory cytokines immediately following exercise. This acute suppression of colon cancer cell number was transient and not observed at 120 minutes post-acute HIIE. The acute effects of exercise may constitute an important mechanism by which exercise can influence colorectal cancer outcomes. Abstract Physical activity is associated with significant reductions in colorectal cancer mortality. However, the mechanisms by which exercise mediates this anti‐oncogenic effect are not clear. In the present study, colorectal cancer survivors completed acute (n = 10) or chronic (n = 10) exercise regimes. An acute high intensity interval exercise session (HIIE; 4 × 4 min at 85–95% peak heart rate) was completed with serum samples collected at baseline, as well as 0 and 120 min post‐exercise. For the ‘chronic’ intervention, resting serum was sampled before and after 4 weeks (12 sessions) of HIIE. The effect of serum on colon cancer cell growth was evaluated by incubating cells (CaCo‐2 and LoVo) for up to 72 h and assessing cell number. Serum obtained immediately following HIIE, but not 120 min post‐HIIE, significantly reduced colon cancer cell number. Significant increases in serum interleukin‐6 (P = 0.023), interleukin‐8 (P = 0.036) and tumour necrosis factor‐α (P = 0.003) were found immediately following acute HIIE. At rest, short‐term HIIE training did not promote any changes in cellular growth or cytokine concentrations. The acute effects of HIIE and the cytokine flux may be important mediators of reducing colon cancer cell progression. Repetitive exposure to these acute effects may contribute to the relationship between exercise and improved colorectal cancer survival.

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Section: Methodsmentioning

confidence: 97%

“…Further details of the safety and feasibility of this intervention are reported elsewhere (Devin et al . ).…”

Section: Methodsmentioning

confidence: 97%

Acute high intensity interval exercise reduces colon cancer cell growth

Devin

Hill

Mourtzakis

et al. 2019

The Journal of Physiology

Self Cite

105

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“…Recently, there has been particular interest in the use of high intensity interval training [85–95% peak heart rate (HR peak ) interspersed with period of active recovery] for improving CRF, body composition, and quality of life in oncological populations for managing treatment-related side effects [26–28]. In colorectal cancer survivors, 12 supervised high intensity interval training sessions (4x4 min bouts of cycling at 85–95% HR peak , interspersed with 3 min of active recovery at 50–70% HR peak ) performed over 4 weeks showed greater improvements in cardiorespiratory fitness and total body mass, when compared to 12 supervised moderate intensity exercise sessions (50 min of cycling at 50-70% HR peak ) [29]. Thus, high intensity interval training may provide an optimal exercise prescription for improving various aspects of health that are typically impaired with ADT; however exercise at this intensity is yet to be conducted in men with prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

Nutrition therapy with high intensity interval training to improve prostate cancer-related fatigue in men on androgen deprivation therapy: a study protocol

et al. 2017

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BackgroundCancer-related fatigue is one of the most prevalent, prolonged and distressing side effects of prostate cancer treatment with androgen deprivation therapy. Preliminary evidence suggests natural therapies such as nutrition therapy and structured exercise prescription can reduce symptoms of cancer-related fatigue. Men appear to change their habitual dietary patterns after prostate cancer diagnosis, yet prostate-specific dietary guidelines provide limited support for managing adverse side effects of treatment. The exercise literature has shown high intensity interval training can improve various aspects of health that are typically impaired with androgen deprivation therapy; however exercise at this intensity is yet to be conducted in men with prostate cancer. The purpose of this study is to examine the effects of nutrition therapy beyond the current healthy eating guidelines with high intensity interval training for managing cancer-related fatigue in men with prostate cancer treated with androgen deprivation therapy.Methods/designThis is a two-arm randomized control trial of 116 men with prostate cancer and survivors treated with androgen deprivation therapy. Participants will be randomized to either the intervention group i.e. nutrition therapy and high intensity interval training, or usual care. The intervention group will receive 20 weeks of individualized nutrition therapy from an Accredited Practising Dietitian, and high intensity interval training (from weeks 12–20 of the intervention) from an Accredited Exercise Physiologist. The usual care group will maintain their standard treatment regimen over the 20 weeks. Both groups will undertake primary and secondary outcome testing at baseline, week 8, 12, and 20; testing includes questionnaires of fatigue and quality of life, objective measures of body composition, muscular strength, cardiorespiratory fitness, biomarkers for disease progression, as well as dietary analysis. The primary outcomes for this trial are measures of fatigue and quality of life.DiscussionThis study is the first of its kind to determine the efficacy of nutrition therapy above the healthy eating guidelines and high intensity interval training for alleviating prostate-cancer related fatigue. If successful, nutrition therapy and high intensity interval training may be proposed as an effective therapy for managing cancer-related fatigue and improving quality of life in men during and after prostate cancer treatment.Trial registrationAustralian New Zealand Clinical Trials Registry ACTRN12615000512527. Trial registered on the 22/5/2015.

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“…HIT drives the metabolism much harder than regular aerobic training and adaptation in endurance and strength occur faster. Recent studies prove the beneficial effect of combined HIT and moderate training also for cancer patients [17,18].…”

Section: Discussionmentioning

confidence: 95%

Juvenile competitive triathlete after cardiotoxic anthracycline therapy for Acute Myeloid Leukemia

et al. 2016

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Objective: The treatment of Acute Myeloid Leukemia (AML) leads to several functional limitations. Especially cardiac burden following cardiotoxic chemotherapy, which limits exercise and competitive sport in the long-term survivors. Subject and methods: We report on a young female amateur triathlete born in 1997, who was diagnosed with AML at the age of fifteen. She had chemotherapy with a cumulative dose of about 1000 mg/m 2 anthracyclines and allogeneic stem cell transplantation which was successful, but she suffered from cardiotoxic systolic heart failure with a left ventricular ejection fraction (LVEF) <55 % and an impaired peak oxygen uptake of 23.2 ml/min/kg and 53 % of predicted, respectively. After medical examination and counselling with a sport scientist she started a tailored training of aerobic exercise. She was evaluated at regular intervals which resulted in increasing the training load and volume. Eventually her training hours was stepwise increased to 12 h training per week, which includes high intensity intervals. Results: Within almost 3 years, her exercise performance improved tremendously. Workload doubled from 2.1 W/kg to 4.2 W/kg, peak oxygen uptake increased from 23.2 ml/min/kg to 49.1 ml/min/kg and from 53 to 135 %, respectively. Moreover, she participated in several competitions. However, LVEF remains almost unchanged. Conclusion: With the right training and under medical surveillance competitive exercise with an anthracycline-damaged heart is still achievable. Moreover, competitive training and exercise seems to be safe and feasible.

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The influence of high-intensity compared with moderate-intensity exercise training on cardiorespiratory fitness and body composition in colorectal cancer survivors: a randomised controlled trial

Abstract: HIE appears to offer superior improvements in cardiorespiratory fitness and body composition in comparison to current physical activity recommendations for colorectal cancer survivors and therefore may be an effective clinical utility following treatment.

Cited by 99 publications

References 57 publications

Acute high intensity interval exercise reduces colon cancer cell growth

Acute high intensity interval exercise reduces colon cancer cell growth

Nutrition therapy with high intensity interval training to improve prostate cancer-related fatigue in men on androgen deprivation therapy: a study protocol

Juvenile competitive triathlete after cardiotoxic anthracycline therapy for Acute Myeloid Leukemia

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