The Influence of HLA Alleles on the Affective Distress Profile

Vică, Mihaela Laura; Delcea, Cristian; Dumitrel, Gabriela-Alina; Vuscan, Mihaela Elvira; Matei, Horea; Teodoru, Cosmin Adrian; Siserman, Costel Vasile

doi:10.3390/ijerph191912608

Cited by 6 publications

(4 citation statements)

References 36 publications

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“…Therefore, the study was conducted on a cohort of 130 individuals of Romanian origin, the population for whom HLA association studies with COVID-19 had not been conducted before. Furthermore, there are few studies regarding the frequency of HLA alleles and haplotypes in the population of this region [36,37], and our previous studies have attempted to determine correlations between HLA alleles and certain infectious diseases or mental conditions in this population [10,[38][39][40].…”

Section: Discussionmentioning

confidence: 99%

The Influence of HLA Polymorphisms on the Severity of COVID-19 in the Romanian Population

Vică,

Dobreanu,

Curocichin

et al. 2024

IJMS

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In this study, we aimed to investigate whether specific HLA alleles found in patients from Romania and the Republic of Moldova were associated with the severity of COVID-19 infection and its associated mortality. We analyzed the HLA alleles at the -A, -B, -C, -DRB1, and -DQB1 loci in a cohort of 130 individuals with severe and extremely severe forms of COVID-19, including 44 individuals who died. We compared these findings to a control group consisting of individuals who had either not been diagnosed with COVID-19 or had experienced mild forms of the disease. Using multivariate logistic regression models, we discovered that the B*27 and B*50 alleles were associated with an increased susceptibility to developing a severe form of COVID-19. The A*33 and C*15 alleles showed potential for offering protection against the disease. Furthermore, we identified two protective alleles (A*03 and DQB1*02) against the development of extremely severe forms of COVID-19. By utilizing score statistics, we established a statistically significant association between haplotypes and disease severity (p = 0.021). In summary, this study provides evidence that HLA genotype plays a role in influencing the clinical outcome of COVID-19 infection.

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Section: Discussionmentioning

confidence: 99%

The Influence of HLA Polymorphisms on the Severity of COVID-19 in the Romanian Population

Vică,

Dobreanu,

Curocichin

et al. 2024

IJMS

Self Cite

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“…Previous studies have suggested that some of these HLA alleles may reduce the risk of anxiety and depression. For example, a correlation study based on PCR technique highlighted potential associations between lower anxiety disorders and HLA alleles, such as HLA‐DRB1 locus ( DRB1*11 ) and HLA‐A locus ( A*30 ) 32 . Using non‐parametric Spearman's rank correlation, Bandinelli et al found that HLA‐DRB1*11 ‐positive early undifferentiated arthritis patients had lower symptom of depression and anxiety 33 .…”

Section: Discussionmentioning

confidence: 99%

“…between lower anxiety disorders and HLA alleles, such as HLA-DRB1 locus (DRB1*11) and HLA-A locus (A*30). 32 Using non-parametric Spearman's rank correlation, Bandinelli et al found that HLA-DRB1*11-positive early undifferentiated arthritis patients had lower symptom of depression and anxiety. 33 Similarly, our findings indicate that HLA-A*30:04 and HLA-DRB1*03:01 have modest protective effects in depression, suggesting that these alleles do not harbor risk for depression.…”

Section: Hla Allelementioning

confidence: 99%

Associations of classical HLA alleles with depression and anxiety

Cheng,

Yang,

Cheng

et al. 2023

HLA

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Immune dysregulation has been widely observed in patients with psychiatric disorders. This study aims to examine the association between HLA alleles and depression and anxiety. Using data from the UK Biobank, we performed regression analyses to assess the association of 359 HLA alleles with depression and anxiety, as determined by Patient Health Questionnaire (PHQ) score (n = 120,033), self‐reported depression (n = 121,685), general anxiety disorder (GAD‐7) score (n = 120,590), and self‐reported anxiety (n = 108,310). Subsequently, we conducted gene environmental interaction study (GEIS) to evaluate the potential effects of interactions between HLA alleles and environmental factors on the risk of depression and anxiety. Sex stratification was implemented in all analysis. Our study identified two significant HLA alleles associated with self‐reported depression, including HLA‐C*07:01 (β = −0.015, p = 5.54 × 10−5) and HLA‐B*08:01 (β = −0.015, p = 7.78 × 10−5). Additionally, we identified four significant HLA alleles associated with anxiety score, such as HLA‐DRB1*07:01 (β = 0.084, p = 9.28 × 10−5) and HLA‐B*57:01 (β = 0.139, p = 1.22 × 10−4). GEIS revealed that certain HLA alleles interacted with environmental factors to influence mental health outcomes. For instance, HLA‐A*02:07 × cigarette smoking was associated with depression score (β = 0.976, p = 1.88 × 10−6). Moreover, sex stratification analysis revealed significant sex‐based differences in the interaction effects of certain HLA alleles with environmental factors. Our findings indicate the considerable impact of HLA alleles on the risks of depression and anxiety, providing valuable insights into the functional relevance of immune dysfunction in these conditions.

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“…The human leukocyte antigen (HLA)-DRB1 is implicated in histocompatibility and a wide range of immune responses. HLA-DRB1 genetic variants have been associated with anxiety [ 71 ], affective distress [ 72 ], and schizophrenia [ 73 ] in non-AD populations. Furthermore, specific SNPs in HLA-DRB1 have been related to the altered volume of the left posterior cingulate gyrus in a large sample of patients with MCI and normal cognition, suggesting their potential role especially in the early stages of AD [ 74 ].…”

Section: The Relationship Between Other Alzheimer’s Disease (Ad)-rela...mentioning

confidence: 99%

Exploring the Genetic Landscape of Mild Behavioral Impairment as an Early Marker of Cognitive Decline: An Updated Review Focusing on Alzheimer’s Disease

Angelopoulou,

Koros,

Hatzimanolis

et al. 2024

IJMS

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The clinical features and pathophysiology of neuropsychiatric symptoms (NPSs) in dementia have been extensively studied. However, the genetic architecture and underlying neurobiological mechanisms of NPSs at preclinical stages of cognitive decline and Alzheimer’s disease (AD) remain largely unknown. Mild behavioral impairment (MBI) represents an at-risk state for incident cognitive impairment and is defined by the emergence of persistent NPSs among non-demented individuals in later life. These NPSs include affective dysregulation, decreased motivation, impulse dyscontrol, abnormal perception and thought content, and social inappropriateness. Accumulating evidence has recently begun to shed more light on the genetic background of MBI, focusing on its potential association with genetic factors related to AD. The Apolipoprotein E (APOE) genotype and the MS4A locus have been associated with affective dysregulation, ZCWPW1 with social inappropriateness and psychosis, BIN1 and EPHA1 with psychosis, and NME8 with apathy. The association between MBI and polygenic risk scores (PRSs) in terms of AD dementia has been also explored. Potential implicated mechanisms include neuroinflammation, synaptic dysfunction, epigenetic modifications, oxidative stress responses, proteosomal impairment, and abnormal immune responses. In this review, we summarize and critically discuss the available evidence on the genetic background of MBI with an emphasis on AD, aiming to gain insights into the potential underlying neurobiological mechanisms, which till now remain largely unexplored. In addition, we propose future areas of research in this emerging field, with the aim to better understand the molecular pathophysiology of MBI and its genetic links with cognitive decline.

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The Influence of HLA Alleles on the Affective Distress Profile

Cited by 6 publications

References 36 publications

The Influence of HLA Polymorphisms on the Severity of COVID-19 in the Romanian Population

The Influence of HLA Polymorphisms on the Severity of COVID-19 in the Romanian Population

Associations of classical HLA alleles with depression and anxiety

Exploring the Genetic Landscape of Mild Behavioral Impairment as an Early Marker of Cognitive Decline: An Updated Review Focusing on Alzheimer’s Disease

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