The Influence of Hormonal Treatment and Orchiectomy, Oophorectomy and Thyroidectomy on Experimental Fractures: A Quantitative P³²-Autoradiographic, Roentgenologic and Tissue-Analytic Study

Evaluating the Affect and Reversibility of Opioid-induced Androgen Deficiency in an Orthopaedic Animal Fracture Model

“…To our knowledge, the effect of opioid-induced hypogonadism on osseous healing in the acute fracture setting has not been examined. The literature shows that physiologic and supraphysiologic testosterone levels support osseous strength and healing and supplemental testosterone may improve fracture healing, particularly in hypogonadal models [5,13,16,19,21,22,28,31,32]. The testosterone suppression seen with opioidinduced androgen deficiency may be the driving mechanism behind fracture callus suppression seen with opioid administration.…”

Fracture Callus and Mast Cells in Rats with Calcium and Vitamin D Deficiency

“…The process of callus formation has been the subject of recent studies; Koskinen (1965) and Slatis & Rokkanen (1965) have considered histological, histoquantitative and radiological aspects, whereas Aho (1966) has done work with the electron microscope. Microradiography was used by Nilsonne (1959) to study the mineral phase of fracture repair.…”

“…Microradiography was used by Nilsonne (1959) to study the mineral phase of fracture repair. Tetracycline fluorescence combined with microangiography and microradiography (Hult & Olerud 1964, Slatis & Rokkanen 1967 and labelling with radioactive isotopes (Koskinen 1965, McDonald et al 1957, Solheim 1965 have also been tried. The callus mast cell has been investigated by, among others, his co-workers (1967, 1969).…”

Autoradiographic Demonstration of Sulphated Mucopolysaccharides in Fibrous Callus Mast Cells in Fracture Repair in Rats

“…A great number of studies concerning fracture repair using radioactive isotopes are to be found in the previous literature (e.g. Duthie & Barker 1955, Singh & Udupa 1964, Koskinen 1965. No evidence of the uptake of ' 3 by mast cells in fracture callus has hitherto been reported, despite the publication of detailed observations of the incorporation of this isotope in the growing epiphyses proximal and distal to the fracture (Duthie & Barker 1955).…”