The Influence of HPC-L and Eudragit L30 D-55 on Delayed Release Omeprazole Magnesium Multiple-Unit Pellet System

Mummidi, Varalakshmi; Rezwana, Shaik

doi:10.22159/ajpcr.2018.v11i7.25098

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…Solid dispersion of furosemide pellets for oral administration to improve the solubility [37]. Delayed-release pellets of omeprazole magnesium, which is unstable in stomach pH, hence formulated as delayed-release dosage form to allow absorption in intestinal pH [38]. Deshkar et al, designed curcumin solid dispersion pellets for improving the solubility of poorly soluble curcumin and observed a significant enhancement in dissolution compared to pure curcumin pellets [39].…”

Section: Drug and Excipientsmentioning

confidence: 99%

An Outline of Variables in Pelletization by Extrusion and Spheronization

Mishra¹,

Paldewar²,

Nandgude³

2020

Int J App Pharm

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Pelletization is an agglomeration process which converts fine granules or powders of bulk drugs into small, free-flowing, spherical units, known as pellets. The pelletization can be achieved either through agitation, compaction (extrusion-spheronization), drug layering and globulation. Among the various pelletization techniques extrusion–spheronization process is preferred over other methods for the preparation of pellets as it allows the incorporation of the higher amount of drug, modified physical characteristics of the drug (density, sphericity, narrow size distribution, smoother surface) and multiple drugs can be easily combined in the same unit. This current review summarizes the findings or investigations by the researchers on various variables, including process parameters, equipment parameters and formulation parameters influencing the quality of pellets. The article also focuses on process optimization and additives used in pellets formulation. To prepare the current review search criterion used was the parameters affecting final pellet characterization in the extrusion spheronization process. The sources were peer-reviewed relevant scientific articles of recognized journals. Keywords used as filters were extrusion, spheronization, formulation parameters, process parameters, equipment parameters, moisture content, granulating liquid, drying rate, extrusion temperature, spheronizer load, pelletization. Literature survey has been done in a range of years (1992-2019) regarding the various variables of the extrusion spheronization process, which affects and has foremost impact on the final quality of pellets so as to make the review updated and comprehensive.

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Section: Drug and Excipientsmentioning

confidence: 99%

An Outline of Variables in Pelletization by Extrusion and Spheronization

Mishra¹,

Paldewar²,

Nandgude³

2020

Int J App Pharm

View full text Add to dashboard Cite

show abstract

The role of coatings and plasticizers compatibility in stability of advanced gastro-resistant self-emulsifying pellets designed for the delivery of volatile compounds: A combined solid-state NMR and dissolution study

Macku,

Vyslouzil,

Muselik

et al. 2024

Journal of Drug Delivery Science and Technology

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Optimisation of the Manufacturing Process of Organic-Solvent-Free Omeprazole Enteric Pellets for the Paediatric Population: Full Factorial Design

Rouaz-El-Hajoui,

García-Montoya,

López-Urbano

et al. 2023

Pharmaceutics

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Liquid formulations are mostly used in the paediatric population. However, with certain active pharmaceutical ingredients (APIs), it is very difficult to guarantee quality and stability; this is the case, for example, with omeprazole. Omeprazole is used as a model drug due to the lack of a paediatric formulation meeting gastro-resistance requirements, which remains a challenge today. In this experimental study, the development of enteric polymer-coated pellets is proposed. It is proposed to use aqueous coating dispersions without the use of organic solvents, which are commonly used in fluidised bed coatings. To do this, the design of experiments method is used as a statistical tool for experiment creation and the subsequent analysis of the responses. In particular, this study uses a randomised full factorial design. The mean weight increases of the protective layer and the enteric coating are chosen as factors. Each factor is assigned two levels. Therefore, the design of the used experiments is a 22 + 1 central point. Overall, the obtained pellets can be an alternative to the compounding formulas of omeprazole that are currently used in the paediatric population, which do not meet the gastro-resistance specifications necessary to guarantee the therapeutic efficacy of this active ingredient.

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The Influence of HPC-L and Eudragit L30 D-55 on Delayed Release Omeprazole Magnesium Multiple-Unit Pellet System

Cited by 3 publications

References 17 publications

An Outline of Variables in Pelletization by Extrusion and Spheronization

An Outline of Variables in Pelletization by Extrusion and Spheronization

The role of coatings and plasticizers compatibility in stability of advanced gastro-resistant self-emulsifying pellets designed for the delivery of volatile compounds: A combined solid-state NMR and dissolution study

Optimisation of the Manufacturing Process of Organic-Solvent-Free Omeprazole Enteric Pellets for the Paediatric Population: Full Factorial Design

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