The Influence of Hypercalcemia on Gastric Secretion and Serum Gastrin Concentration in Intact and Thyro-parathyroidectomized Rats

hyperparathyroidism and its effect on serum gastrin, gastrin cells and antral gastrin in the rat. Acta path. microbiol. immunol. scand. Sect. A, 90: 409-416, 1982. Parathyroid glands from inbred rats were transplanted to rats of the same strain. The transplantation resulted in hyperparathyroidism and persistent hypercalcaemia. These hypercalcaemic animals were compared with the hypocalcaemic donors and with untreated controls. No significant differences in serum gastrin values were found between the different groups. In all three groups, one series of animals was killed 6 weeks after the transplantation (6w series) and another after 14 weeks (14w series). Quantitative studies of the antral gastrin cells showed an increase in the number of these cells per unit volume in the 6w series in the hyperparathyroid recipient animals. The number of gastrin cells per unit segment was also higher in the recipient animals than in the parathyroidectomized and untreated groups in both the 6w and 14w series. The amount of gastrin extracted from antral mucosa did not differ between the different groups. The findings show that an experimentally induced hyperparathyroidism in the rat gives a transient increase in the number of antral gastrin cells but no changes in the antral gastrin or serum gastrin levels.

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Vitamin‐d‐induced Hypercalcaemia and Its Effect on Serum Gastrin, Gastrin Cells and Antral Gastrin in Parathyroidectomized Rats

Selking

Grimelius

Johansson

et al. 1982

Acta Pathologica Microbiologica Scandinavica Series A :Patholog

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D-induced hypercalcaemia and its effect on serum gastrin, gastrin cells and antral gastrin in parathyroidectomized rats. Acta path. microbiol. immunol. scand. Sect. A, 90: 417-421, 1982.Nineteen rats were parathyroidectomized by electrocauterization, resulting in pronounced hypocalcaemia. Seven of these rats were then given vitamin D3 in a dose causing hypercalcaemia, while 7 received a dose which normalized serum calcium and 5 received no vitamin D. Ten further animals were shamoperated and were not given any extra vitamin D. The experimental period was 16 weeks. No significant differences in serum gastrin values were found between the different groups. Quantitative studies of the antral gastrin cells showed no difference in the number of gastrin cells per unit volume or unit segment between the different groups of vitamin-D-treated animals and sham-operated animals. However, the number of gastrin cells per unit segment was significantly higher in the hypocalcaemic animals than in the sham-operated animals, as a result of an increase in mucosal thickness. The amount of antral mucosal gastrin did not differ between the different groups. Thus the results of this study indicate that experimentally induced hypercalcaemia in parathyroidectomized rats does not influence the serum gastrin, the number of gastrin cells or antral gastrin.

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The Influence of Hypercalcemia on Gastric Secretion and Serum Gastrin Concentration in Intact and Thyro-parathyroidectomized Rats

Cited by 3 publications

References 8 publications

Effect of vitamin D on gastrin and gastric somatostatin secretion from the isolated perfused rat stomach

Effect of vitamin D on gastrin and gastric somatostatin secretion from the isolated perfused rat stomach

Experimental Hyperparathyroidism and Its Effect on Serum Gastrin, Gastrin Cells and Antral Gastrin in the Rat

Vitamin‐d‐induced Hypercalcaemia and Its Effect on Serum Gastrin, Gastrin Cells and Antral Gastrin in Parathyroidectomized Rats

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